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Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 79
Published: 03 August 2016
10.1159/000445130
EISBN: 978-3-318-05854-3
... Abstract Innate lymphoid cells (ILCs) are a recently discovered subset of innate immune cells that are capable of secreting great amounts of cytokines that have been found to influence effector cell activity. Chronic rhinosinusitis (CRS) in the absence (CRSsNP) or presence (CRSwNP) of nasal...
Book Chapter
Series: Contributions to Microbiology
Volume: 15
Published: 17 June 2008
10.1159/000135683
EISBN: 978-3-8055-8549-1
... Abstract The innate immunity plays a critical role in host protection against pathogens and transformed cells. It reliesamongst others on pattern recognition receptors such as Toll-like receptors, C-type lectin receptors, andnucleotide-binding oligomerization domain proteins to alert...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 43
Published: 04 May 2020
10.1159/000504480
EISBN: 978-3-318-06678-4
... Abstract The collective loss of immune protection during aging leads to poor vaccine responses and an increased severity of infection for the elderly. Here, we review our current understanding of effects of aging on the cellular and molecular dysregulation of innate immune cells as well...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500382
EISBN: 978-3-318-06540-4
... tubulointerstitial lesions is an early manifestation of systemic leptospirosis. Leptospira may colonize and persist in the proximal tubule, leading to a carrier state that may progress to chronic tubulointerstitial inflammation and fibrosis. The innate immune system is an important modulator of the inflammatory...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 31
Published: 02 August 2017
10.1159/000470808
EISBN: 978-3-318-06051-5
... transmission, synaptic plasticity, and neuronal survival - changes that characterize neuroprogression. We draw on recent findings in the immunology literature that peripheral innate immune cells are capable of retaining long-term memory of infectious insults and displaying long-lasting upregulated...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 31
Published: 02 August 2017
10.1159/000470809
EISBN: 978-3-318-06051-5
... patients with mood disorders. However, cytokine abnormalities in the brain may also contribute toward neuroprogression, but brain cytokines have not been adequately investigated. To examine the role of cytokines in neuroprogression, we have studied the markers of adaptive and innate immunity in postmortem...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 79
Published: 03 August 2016
10.1159/000445132
EISBN: 978-3-318-05854-3
... disruption may contribute to CRS by enabling the perpetual and chronic exposure of inflammatory allergens and stimuli. The sinonasal epithelial barrier plays a significant role in innate immune host defense. Mechanisms of innate immune defense include pattern recognition receptors (PRRs), secreted endogenous...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
10.1159/000381409
EISBN: 978-3-318-05474-3
... Abstract A characteristic feature of active inflammatory bowel disease is the infiltration of innate and adaptive immune cells into the intestinal lamina propria. This complex mixture of a broad variety of cells should ensure that inflammatory responses to invading pathogens are sufficient...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 79
Published: 10 September 2014
10.1159/000360676
EISBN: 978-3-318-02670-2
... inflammatory response is due in part to genetic alterations in the normal homeostatic processes that regulate host interactions with the normal gut microbes. Genetic studies have identified increasing numbers of genetic risk factors that involve a diverse series of pathways such as receptors of innate immune...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346526
EISBN: 978-3-318-02348-0
... susceptibility to experimental colitis. Taken together, the NF-ĸB-IL-6-STAT3 pathway links innate immunity to tumorigenesis by promoting the survival and proliferation of tumor-initiating cells. IL-6 and other cytokines may also enhance cancer progression. A link between inflammation and cancer has been...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346531
EISBN: 978-3-318-02348-0
... rejection and chronic allograft failure. From these convincing clinical data, we concluded in terms of an ‘argumentum e contrario': it is the tissue injury that induces immunity. As from where we stand today in innate immunity research, these early clinical observations can be regarded as the discovery...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346527
EISBN: 978-3-318-02348-0
... pathways regulate tissue damage, and integration of different players into a unified mechanism is warranted. Here, we focus on recent progress in the mechanism of liver innate immune activation by IR. Kupffer cells, dendritic cells, NK, as well as T cells initiate local inflammation response, the hallmark...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346504
EISBN: 978-3-318-02348-0
... Abstract Maintenance of epithelial barrier function and restoration of tissue homeostasis after injury are essential to limit exposure to commensal and pathogenic microbes at barrier sites such as the lung, skin and intestine. Innate lymphoid cells (ILCs) are a recently recognized family...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346535
EISBN: 978-3-318-02348-0
... Abstract miRNAs are a large class of small non-coding RNA that regulate gene expression mainly by transcriptional suppression. miRNAs are integral to the normal functioning of a cell, play an important role in modulating the innate immune response, and are known to enhance or repress TLR...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346509
EISBN: 978-3-318-02348-0
... Abstract Alzheimer's disease (AD) is a chronic neurodegenerative disease that afflicts a growing number of patients worldwide. It has become increasingly clear that innate immune processes are involved in the development and progression of the disease. Here, we discuss innate immune mechanisms...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346516
EISBN: 978-3-318-02348-0
... the cross-regulation of metabolism and immunity in health and disease are only beginning to emerge. We use the model organism Drosophila melanogaster to gain insights into evolutionary conserved mechanisms by which energy homeostasis and innate immunity interact. The Innate Immune System...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346530
EISBN: 978-3-318-02348-0
... serves an innate immune sentinel function against bacterial PN by rapidly recruiting neutrophils into the infected kidney. Bacterial pyelonephritis (PN) is the most relevant kidney infection and one of the most prevalent infections worldwide. Chronic PN may cause terminal kidney failure...
Book
Book Cover Image
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/isbn.978-3-318-02348-0
EISBN: 978-3-318-02348-0
Book Chapter
Series: Frontiers of Oral Biology
Volume: 15
Published: 02 November 2011
10.1159/000329670
EISBN: 978-3-8055-9834-7
... Abstract This chapter addresses the host responses to the microbial biofilm that constitutes the subgingival dental plaque. The host response to infection draws upon the innate, inflammatory and adaptive immune systems, whose role is to provide the appropriate response to the offending...
Book Chapter
Series: Frontiers of Oral Biology
Volume: 15
Published: 02 November 2011
10.1159/000329673
EISBN: 978-3-8055-9834-7
... that recruit and activate antigen-presenting cells to enhance innate and adaptive immune responses. The differential regulation of AMP expression in periodontal disease suggests that AMP panels, including up- and downregulated proteins, can be used in oral fluid diagnosis of periodontal disease and to monitor...