... was latterly proven to be correct by Oscar Minkowski. More than 130 years later SGLT inhibitors were introduced into diabetes treatment. After the introduction of the first SGLT inhibitor in the USA, the FDA received notice that following SGLT inhibition cases of severe ketoacidosis occurred. Sadly, the FDA...

... array of disease-modulating targets for the research and development of molecular therapeutic interventions. While the precise in vivo effects of complement activation and inhibition in the progression and treatment of AMD remain to be determined, ongoing clinical trials of the first generation...

... Abstract Reports unraveling the beneficial effects of Viscum album (VA) preparations as complementary therapies for cancer have increasingly revealed the underlying molecular and cellular mechanisms, which encompass cytotoxic properties, induction of apoptosis, inhibition of angiogenesis...

... with mammary, liver and lung cancer had greater mean age at death in the eRapa group. In addition, lymphoma and hemangiosarcoma as the cause of death was reduced in eRapa treated group. These data indicate that mTOR inhibition over the major portion of the life in mice pharmacologically mimics diet...

... inhibitors that have better safety profiles than what is currently available. It has long been recognized that the nonredox active site inhibitors have apparently lower efficacy in chronic inflammatory models ( 18 - 19 ) and that much higher doses were needed to inhibit leukotriene production in vivo...

..., the cyclic nucleotides cAMP and cGMP, and the elements associated with their homeostatic control have been extensively studied. A large family of phosphodiesterase (PDE) enzymes have been uncovered, and inhibiting cGMP-hydrolyzing PDE5 is useful for disorders of vascular tone. Modulation of cAMP plays...

... thatinhibiting I f . Finally, the mechanism of block of f-channels by ivabradine has particularlyfavorable properties in light of controlling heart rate under variable physiological conditions.In this article, we will discuss how I f inhibition by ivabradine can lead to reduction of heartrate. To this aim, we...