... Abstract Inhaled nitric oxide (NO) is a selective pulmonary vasodilator because it does not reduce systemic blood pressure. Inhaled NO dilates constricted pulmonary vessels by activating guanylate cyclase of pulmonary vascular smooth muscle cells and is inactivated by hemoglobin when...

... Abstract Inhaled nitric oxide is a potent pulmonary vasodilator, having clinically useful properties in improving pulmonary gas exchange and reducing pulmonary vascular resistance. It was officially approved for the clinical use in neonatal persistent pulmonary hypertension (PPHN) and has been...

... Abstract Allergen challenge by inhalation is a very useful clinical and research tool for evaluatingallergic airway disease. Inhalation of allergen leads to cross-linking of allergen-specificIgE bound to IgE receptors on mast cells and basophils. This is followed by activation ofsecretory...

... by measurement of the airway resistance by means of a body plethysmograph. The airway resistance was measured in each child before and after inhalation of the same dose of allergen repeatedly to assess the ‘normal’ bronchial reaction for that specific allergen. Every second time the child was given DSCG before...