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inflammasome

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Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441884
EISBN: 978-3-318-05651-8
... Abstract Inflammasomes, large protein complexes typically consisting of a Nod-like receptor (NLR), adapter protein apoptosis-associated speck-like protein containing CARD (ASC) and caspase-1, are postulated to be activated in response to danger signals arising from tumors. Inflammasomes...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346505
EISBN: 978-3-318-02348-0
... serve as a potential trigger for macrophage infiltration and activation. Emerging evidence shows that inflammasomes, the multiprotein platforms that control the activation and secretion of IL-1β and IL-18 in adipose tissue, impact the adipocyte function and T cell activation. This chapter discusses...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346510
EISBN: 978-3-318-02348-0
... Abstract Inflammasomes are a group of protein complexes built around several proteins including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of exogenous and endogenous microbial, stress and damage signals by inflammasomes results in direct activation of caspase 1, which...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
EISBN: 978-3-318-05651-8
...References References 1. Strowig T, Henao-Mejia J, Elinav E, Flavell R: Inflammasomes in health and disease. Nature 2012;481:278-286. 2. Pang IK, Iwasaki A: Inflammasomes as mediators of immunity against influenza virus. Trends Immunol 2011;32:34-41. 3. Franchi L, Muñoz-Planillo R...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
EISBN: 978-3-318-02348-0
...References References 1. Elinav E, Strowig T, Henao-Mejia J, Flavell RA: Regulation of the antimicrobial response by NLR proteins. Immunity 2011;34:665-679. 2. Strowig T, Henao-Mejia J, Elinav E, Flavell R: Inflammasomes in health and disease. Nature 2012;481:278-286. 3. Gross O...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
EISBN: 978-3-318-02348-0
.... Hotamisligil GS: Inflammation and metabolic disorders. Nature 2006;444:860-867. 11. Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, Dixit VD: The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011;17:179-188. 12...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
EISBN: 978-3-318-02348-0
...: inflammasomes: mechanisms of activation. Clin Exp Immunol 2012;167:369-381. 14. Keller M, Ruegg A, Werner S, Beer HD: Active caspase-1 is a regulator of unconventional protein secretion. Cell 2008;132:818-831. 15. Gross O, Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, Tschopp...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346524
EISBN: 978-3-318-02348-0
... of subsequent adaptive immune responses. In macrophages and monocytes, IL-1β is produced as a pro-cytokine and undergoes enzymatic cleavage by the cysteine protease caspase 1. Caspase 1 itself is processed into its active form upon activation of a multimeric protein complex known as the inflammasome...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346509
EISBN: 978-3-318-02348-0
... active and secreted mature cytokine. Great progress has been made in the last years in the understanding of how the activity of caspase 1 is controlled [ 30 ]. Multi-protein complexes, termed inflammasomes, assemble in the cytosol upon a variety of stimuli, leading to activation of caspase 1. Active...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000350676
EISBN: 978-3-318-02348-0
... inflammasome activation 88, 89 overview 86, 87 γ-Aminobutyric acid, microbial endocrinology 55, 56 Amylin, gut-brain communication in body weight regulation 98 Amyloid-ß, see Alzheimer's disease Antimicrobial peptides Drosophila immune response brain receptors 109 FOXO regulation...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
EISBN: 978-3-318-02348-0
... 1989;86:7611-7615. 29. Simard AR, Soulet D, Gowing G, Julien JP, Rivest S: Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006;49:489-502. 30. Rathinam VA, Vanaja SK, Fitzgerald KA: Regulation of inflammasome signaling. Nat...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346508
EISBN: 978-3-318-02348-0
... inflammatory process. At the latter, activation of the NLRP3 inflammasome by islet amyloid polypeptide may enhance IL-1β production [ 16 , 17 ]. Once IL-1β is upregulated in islets of patients with type 2 diabetes [ 9 , 14 ], it may induce numerous cytokines and also chemokines [ 18 , 19 ]. Thereby...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
EISBN: 978-3-318-02348-0
... compensation to dysfunction. Arch Physiol Biochem 2009;115:240-247. 16. Masters SL, Dunne A, Subramanian SL, Hull RL, et al: Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat Immunol 2010;11:897-904. 17. Westwell-Roper C...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346498
EISBN: 978-3-318-02348-0
... to bind bacterial DNA as well as cyclic di-GMP, a signaling molecule restricted to bacteria. Within the group of NLRs (nucleotide-binding domain leucine-rich repeat-containing receptors), the function of NLRP3 has been highlighted by the work of J. Tschopp. NALP3 was found to trigger ‘inflammasome...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346538
EISBN: 978-3-318-02348-0
... of pro-IL-1β, and subsequent proteolytic conversion of pro-IL-1β to the bioactive and secreted form. The latter event is typically mediated by caspase 1 within the context of cytosolic complexes termed inflammasomes [ 27 ]. Upon cellular infection with C. albicans , CLR-induced Syk signaling is required...
Book
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Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/isbn.978-3-318-02348-0
EISBN: 978-3-318-02348-0
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000324022
EISBN: 978-3-8055-9711-1
... are involved in the formation of the inflammasome, crucial for the maturation of some pro-inflammatory cytokines. Bacterial superantigens have evolved to exploit host MHC class II and T cell receptors (normally considered part of the adaptive immune response) as innate PRRs to propagate a so-called ‘cytokine...
Book Chapter
Series: Frontiers of Oral Biology
Volume: 15
Published: 02 November 2011
EISBN: 978-3-8055-9834-7
... the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 2007;26:433-443 50. Kanneganti TD, Lamkanfi M, Nunez G: Intracellular NOD-like receptors in host defense and disease. Immunity 2007;27:549-559 51. Lamkanfi M, Kanneganti TD, Franchi L, Nunez G: Caspase-1 inflammasomes...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 43
Published: 04 May 2020
EISBN: 978-3-318-06678-4
..., Herzog RI, Iwasaki A, Dixit VD: β-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares. Cell Rep 2017;18:2077–2087. 22. Ziegler-Heitbrock L: Blood Monocytes and Their Subsets: Established Features and Open Questions. Front Immunol 2015;6:423. 23. van Duin D, Mohanty S...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500378
EISBN: 978-3-318-06540-4
... of AKI, was reported to be an early marker of AKI and a predictor of leptospirosis infection outcome [ 15 ]. Role of Proinflammatory Mediators Symptoms of acute leptospirosis are related to unrestrained activation of inflammasomes causing kidney tissue damage. During a leptospirosis infection...