..., it is important to investigate human milk as a system, as different compounds might work together synergistically. Furthermore, its composition needs to be evaluated in the context of maternal health and lifestyle, physiological status, maternal genetics, lactation time, and geography. These are only a few...

... nocturnal sleep despite prolonged fasting [ 4 ], no attempt was made for years to investigate possible relationships between sleep and metabolic function. Over the last 15 years however, a growing number of studies emphasized the importance of the sleep-wake homeostasis in the regulation of energy...

... clinical judgment. Because of this lack of ‘hard’ evidence in nephrology it is not surprising that many of the CPGs practice recommendations are based on expert opinion and/or consensus [ 9 ]. A last important aspect of correct guideline formulation is ‘availability’: the fact that a certain treatment...

... at 12 months). Acute rejection still being one of the most important risk factors for late allograft loss, long-term follow-up data will reveal the efficacy of belatacept in preserving renal allograft function. Importantly, there have been major concerns about the safety of belatacept. Until June 2009...

..., suggesting a role for thisfactor in these pathologies. BAFF has additional functions that may be important in rheumaticdiseases. For instance, excess BAFF leads to the expansion of a subset of B cells named marginalzone (MZ) B cells, a cell type able to activate naive T cells. In addition, expansion of theMZ...