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immunotherapy

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Book Chapter
Book Chapter
Series: Progress in Neurological Surgery
Volume: 32
Published: 23 July 2018
10.1159/000469683
EISBN: 978-3-318-06063-8
... Abstract Current cell-based immunotherapeutic strategies attempt to produce and maintain an immune response against glioma cells by artificially stimulating the immune system using passive and/or active approaches. Cellular immunotherapy is taken to mean the administration of live immune cells...
Book Chapter
Series: Progress in Tumor Research
Volume: 44
Published: 07 May 2018
10.1159/000486981
EISBN: 978-3-318-06362-2
... Abstract Different immunotherapy concepts developed over recent decades include immune checkpoint inhibition, vaccination, and T cell-engaging therapies, as well as effectors on the immunosuppressive tumour microenvironment. For all these immunotherapy approaches, combination studies...
Book Chapter
Published: 05 February 2018
10.1159/000491151
EISBN: 978-1-910797-65-5
Book Chapter
Book Chapter
Series: Progress in Tumor Research
Volume: 42
Published: 09 September 2015
10.1159/000436986
EISBN: 978-3-318-05590-0
... efforts have been made in the last 20 years to develop new therapeutic options for GBM. Among the various approaches investigated, immunotherapy has emerged as a very promising line of attack [ 4 ]. Immunotherapy for Glioma Tumor immunotherapy, defined as use of the immune system to fight cancer...
Book Chapter
Series: Progress in Tumor Research
Volume: 42
Published: 09 September 2015
10.1159/000436998
EISBN: 978-3-318-05590-0
... Abstract The history of immunotherapy is rooted in the treatment of melanoma and therapy with immune checkpoint-blocking agents is now a cornerstone for the treatment of metastatic melanoma. The first effective immunotherapies approved by the US Food and Drug Administration in melanoma included...
Book Chapter
Series: Progress in Tumor Research
Volume: 42
Published: 09 September 2015
10.1159/000437183
EISBN: 978-3-318-05590-0
... will develop more informed attempts to control cancer via immunological approaches. To be effective in breast cancer, immunotherapies will have to increase the quality or quantity of immune effector cells, reveal additional protective tumor antigens, and/or eliminate cancer-induced immunosuppressive mechanisms...
Book Chapter
Series: Progress in Tumor Research
Volume: 42
Published: 09 September 2015
10.1159/000437185
EISBN: 978-3-318-05590-0
... tumor-infiltrating myeloid-derived suppressor cells and consequentially increasing the efficacy of irradiation [ 51 ]. Next to targeted agents, vaccination strategies form an important facet of immunotherapy as well. The beneficial effect of dendritic cell administration was clinically translated...
Book Chapter
Series: Progress in Tumor Research
Volume: 42
Published: 09 September 2015
10.1159/000437179
EISBN: 978-3-318-05590-0
...-based therapies are showing significant promise. In spite of this, the history of cancer immunotherapy attempts is long, and dates back to the late 1800s with the development of bacterial extracts to stimulate the immune system by William Coley, and in more modern times was reinvigorated in 1975 when...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000403885
EISBN: 978-3-318-02773-0
.... This chapter focuses on the importance of novel biomarkers: microRNA and microRNA inhibitors; DNA methylation and epigenetics, and immunotherapy and virotherapy to develop novel treatments for NETs. Novel Biomarkers Our understanding of neuroendocrine tumor (NET) biology and treatments has changed...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 101
Published: 21 May 2015
10.1159/000371697
EISBN: 978-3-318-02341-1
... Abstract The standardized therapeutic approach for food allergy is based on avoidance of allergens in foods. Oral immunotherapy (OIT) is a significant focus of food allergy research and appears to be effective in inducing desensitization. However, most patients receiving OIT have mild...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
10.1159/000360047
EISBN: 978-3-318-02195-0
... Abstract Specific immunotherapy was introduced for the treatment of grass pollen-induced hay fever in 1911. The treatment was soon extended to other pollens as well as perennial allergens, and to the treatment of bronchial asthma. Definitive studies of its efficacy for both rhinitis and asthma...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328268
EISBN: 978-3-8055-9791-3
... Abstract Uveal melanoma is a malignancy with exceptional features for treatment with immunotherapy. Primary uveal melanoma can be treated with a variety of therapies that may limit the growth of the primary tumor in the eye and partially preserve vision. However, none of these treatment...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324631
EISBN: 978-3-8055-9723-4
... Abstract Sublingual immunotherapy has been considered to be a painless and effective therapeutic treatment for allergic rhinitis, and is known as type 1 allergy of the nasal mucosa. So far, its mechanism of action has been elucidated employing peripheral blood serum and lymphocytes...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324775
EISBN: 978-3-8055-9723-4
... immunotherapy may be helpful in management of head and neck cancer and needs to be explored in further detail. Cancer immunotherapy could be expected to be one of the combined modalities as an adjuvant for cancer therapy; however, its efficacy still needs to be improved. Natural killer T (NKT) cells...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000155000
EISBN: 978-3-8055-8629-0
... Abstract Allergen-specific immunotherapy (SIT) is the only treatment which leads to a lifelong tolerance against previously disease-causing allergens due to restoration of normal immunity against allergens. The description of T-regulatory (Treg) cells being involved in prevention...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 91
Published: 20 January 2006
10.1159/000090282
EISBN: 978-3-318-01266-8
... Abstract Allergen-specific immunotherapy (SIT) is the only treatment, which leads to a life-longtolerance against allergens due to restoration of normal immunity. The induction of a tolerantstate in peripheral T cells represents an essential step in allergen-SIT. Peripheral T-cell toleranceis...
Book Chapter