... as immunoexcitotoxicity. In this chapter, we will discuss the common etiology of these three neurological conditions as well as the immunoexcitotoxicity pathway, and introduce potential prevention and metabolic treatment strategies based on the new concept of immunoexcitotoxicity. Altered neuronal function...

.... Luo XG, Ding JQ, Chen SD: Microglia in the aging brain: relevance to neurodegeneration. Mol Neurodegener 2010;5:12. 7. Blaylock RL, Maroon JC: Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy - a unifying hypothesis. Surg Neurol Int 2011;2:107. 8. Bailes JE...

... also know trauma to the head results in a major perturbation in glucose metabolism and also abnormal ionic changes in sodium, potassium, and calcium. Not so well understood or popularized is the immunoexcitotoxic reaction that occurs. Following a blow to the head, microglial cells become activated...

...References References 1. Blaylock RL, Maroon JC: Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy - a unifying hypothesis. Surg Neurol Int 2011;2:107. 2. Guerrero JL, Thurman DJ, Sniezek JE: Emergency department visits associated with traumatic brain injury...

... are not entirely understood, diffuse axonal injury, microvascular changes, blood-brain barrier breakdown, and immunoexcitotoxicity have been implicated [ 3 ]. Much of our knowledge regarding the pathophysiology of repetitive concussion is gleaned from animal models of mTBI. The initial inciting event of mTBI...

... Neuropathol 2009;117:15-18. 49. Blennow K, Hardy J, Zetterberg H: The neuropathology and neurobiology of traumatic brain injury. Neuron 2012;76:886-899. 50. Blaylock RL, Maroon J: Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy - a unifying hypothesis. Surg Neurol Int...

... AL, Bailes JE: Repetitive traumatic brain injury and development of chronic traumatic encephalopathy: a potential role for biomarkers in diagnosis, prognosis, and treatment? Front Neurol 2012;3:186. 13. Blaylock RL, Maroon J: Immunoexcitotoxicity as a central mechanism in chronic traumatic...

... of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol 2009;117:15-18. 49. Blennow K, Hardy J, Zetterberg H: The neuropathology and neurobiology of traumatic brain injury. Neuron 2012;76:886-899. 50. Blaylock RL, Maroon J: Immunoexcitotoxicity as a central mechanism in chronic...