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Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 79
Published: 10 September 2014
10.1159/000360685
EISBN: 978-3-318-02670-2
... Abstract The intestinal mucosa is the largest body surface exposed to the environment. While there are common features when comparing immune responses along the intestinal mucosa, the small bowel and colon exhibit striking differences in their mechanisms driving immune regulation. The vitamin...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 92
Published: 24 January 2007
10.1159/000099278
EISBN: 978-3-318-01404-4
... Abstract The immune surveillance theory proposed almost half a century ago stated that theimmune system was responsible for preventing the formation of spontaneous tumors by identifyingand eliminating neoplastic cells early in their development. Recent studies demonstratingthat innate...
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Book Chapter
Series: Monographs in Oral Science
Volume: 30
Published: 08 March 2022
10.1159/000520784
EISBN: 978-3-318-06913-6
... Abstract Dental caries is a bacteria-mediated disease that inherently triggers a response from the host. The impact of this response is discussed in this chapter with a focus on genes involved in either the innate or the adaptive immune system. Since erosive tooth wear involves losses...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 32
Published: 28 May 2021
10.1159/000510416
EISBN: 978-3-318-06856-6
... integrity. Gut microbes interact with the host in a bi-directional manner as the microbiota can support the development and education of the innate and adaptive immune systems, thereby conferring protection against pathogens and harmful stimuli while training the host to maintain a homeostatic tolerance...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000505336
EISBN: 978-3-318-06685-2
... Abstract The human mammary gland is an integral effector component of the common mucosal immune system. However, from physiological and immunological aspects, it displays several unique features not shared by other mucosal sites. The development, maturation, and activity of the mammary gland...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000505578
EISBN: 978-3-318-06685-2
... Abstract The neonatal immune system has its own reactivity, constraints, and challenges, which profoundly differ from the adult. Breast milk is most probably a key requirement both for optimal immune function in early life and for imprinting of the immune system for long-term immune health...
Book
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 90
Published: 13 March 2019
10.1159/000490301
EISBN: 978-3-318-06341-7
... Abstract Gut immune function conditions the development of local and systemic diseases that result from defects in immune regulation, such as inflammatory bowel disease, allergy and obesity. As epidemiological studies support the developmental origin of health and disease, deciphering...
Book Chapter
Series: Contributions to Nephrology
Volume: 195
Published: 22 May 2018
10.1159/000486943
EISBN: 978-3-318-06350-9
.... In immune-mediated glomerular diseases, a variety of immunomodulatory agents are used to maintain podocytes by systemic immunosuppression, which indirectly ameliorates podocyte injury by interrupting the input of immunological stress. However, in contrast to the indirect therapeutic strategy mediated...
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Book Chapter
Book Chapter
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 31
Published: 02 August 2017
10.1159/000470804
EISBN: 978-3-318-06051-5
... involved in immune activation, oxidative stress, and chronic glucocorticoid exposure. Positron emission tomography studies of the TSPO distribution volume, a marker of microglial activation, provide strong evidence for microglial activation throughout the gray matter of the brain during MDE of MDD...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 31
Published: 02 August 2017
10.1159/000470808
EISBN: 978-3-318-06051-5
... transmission, synaptic plasticity, and neuronal survival - changes that characterize neuroprogression. We draw on recent findings in the immunology literature that peripheral innate immune cells are capable of retaining long-term memory of infectious insults and displaying long-lasting upregulated...