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Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342841
EISBN: 978-3-318-02268-1
..., microcephaly, developmental delay and deafness. Detailed genetic analysis and functional experiments have shown that IGF-1 plays a key role in pre- and postnatal growth and development in human. Eleven patients with heterozygous and 2 patients with compound heterozygous mutations in the type 1 IGF1 receptor...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 71
Published: 24 January 2013
10.1159/000342548
EISBN: 978-3-318-02270-4
... Abstract The IGF system plays a critical role in all phases of human growth, including intrauterine, childhood and pubertal. The importance of IGF-I for both in utero as well as postnatal human growth is highlighted by rare human homozygous IGF1 mutations, which are characterized...
Book
Book Cover Image
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/isbn.978-3-318-01215-6
EISBN: 978-3-318-01215-6
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 40
Published: 09 October 2014
10.1159/000364982
EISBN: 978-3-318-02730-3
... Abstract Inactivation of the GH/insulin/IGF-1 signaling molecules corresponding genes as well as the inactivation of serine/threonine protein kinase mTOR increases life span in nematodes, fruit flies and mice. Evidence has emerged that antidiabetic biguanides and rapamycin are promising...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342573
EISBN: 978-3-318-02268-1
... to the transcription of several genes, including insulin-like growth factor 1 (IGF-1), IGFBP3, ALS, and others. Recent findings indicate that nutrition plays an important role in GH secretion and action. Furthermore, data are emerging which suggest that the RAS-MAPK pathway as well as epigenetic regulation...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342578
EISBN: 978-3-318-02268-1
... Abstract GH insensitivity, also known as primary IGF-1 deficiency (PIGFD), presents as growth failure, and in its severe form is associated with dysmorphic and metabolic abnormalities. PIGFD is caused by genetic defects in the GH-IGF-1 axis. The field of PIGFD due to mutations affecting GH...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 68
Published: 06 October 2011
10.1159/000325914
EISBN: 978-3-8055-9746-3
... Abstract Insulin and insulin-like signaling regulate survival and lifespan in a variety of animal species, from nematodes and flies to higher vertebrates and mammals. Recently, it was shown that brain IGF-I receptor and brain IRS2 control mammalian lifespan, and that this occurs through...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 67
Published: 15 February 2011
10.1159/000325577
EISBN: 978-3-8055-9587-2
... in adulthood. Stature is also a marker for levels of insulin-like growth factor (IGF)-I in childhood. Levels of IGF-I are nutritionally regulated and are therefore modifiable. Milk intake in childhood and in adulthood is positively associated with higher levels of circulating IGF-I and, in children, higher...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321243
EISBN: 978-3-8055-9644-2
...) type 1 (and 2), an extensive knowledge on the interplay between them is crucial as nowadays treatment options for obesity using the 11β-HSD1 are emerging. Much is known about the effects of growth hormone (GH) on insulin- like growth factor- I (IGF- I) generation [ 1 ]. This also accounts...
Book Chapter
Book Chapter
Series: Endocrine Development
Volume: 14
Published: 26 February 2009
10.1159/000207483
EISBN: 978-3-8055-9042-6
... Abstract Major advances in the diagnosis and characterisation of growth hormone (GH) and IGF-I resistant disorders have occurred during the past 15 years. With these advances has come the realisation that there is broad phenotypic variation within these diagnostic categories. We discuss...
Book Chapter
Series: Endocrine Development
Volume: 11
Published: 20 November 2007
10.1159/000111053
EISBN: 978-3-8055-8348-0
... Abstract The central feature of growth hormone (GH) insensitivity is deficiency of insulin-likegrowth factor-1 (IGF-1) in association with elevated GH secretion. This condition is alsoknown as primary IGF deficiency. There are currently four known genetic causes of GHinsensitivity/primary IGF...
Book Chapter
Series: Endocrine Development
Volume: 11
Published: 20 November 2007
10.1159/000111054
EISBN: 978-3-8055-8348-0
... Abstract The biologic effects of insulin-like growth factor-1 (IGF-1) are mediated by specificcell surface receptors. IGF-1 binding to the extracellular α-subunits activates the tyrosinekinase intrinsic to the cytoplasmic portion of the IGF-1 receptor, leading to autophosphorylationof specific...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 33
Published: 29 September 2005
10.1159/000088406
EISBN: 978-3-318-01261-3
Book Chapter
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/000085716
EISBN: 978-3-318-01215-6
... Abstract In the 50 years since the initial report of the ‘sulfation factor‘ or ‘somatomedin‘hypothesis, the IGF system has established itself as the primary mediator of both intrauterineand postnatal growth in mammals. IGF deficiency (IGFD) has emerged as an important clinicaldiagnosis...
Book Chapter
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/000085718
EISBN: 978-3-318-01215-6
... Abstract The insulin-like growth factor family of ligands, receptors and binding proteinsare critical for many normal physiological functions. These include normal development duringfetal and post-natal development and maintenance of organ function in adult life.Circulating IGF-I is produced...
Book Chapter
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/000085756
EISBN: 978-3-318-01215-6
... Abstract Quantitative measurements of serum IGF-I concentrations are extremely useful in thediagnosis of growth hormone deficiency in children and young adults and in the diagnosis ofacromegaly. Similarly, IGF-I measurements have been of great use to clinical investigatorswho are monitoring...
Book Chapter
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/000085757
EISBN: 978-3-318-01215-6
... Abstract The diagnosis of growth hormone (GH) deficiency (GHD) in childhood is not straightforward,being still based on a comprehensive clinical, anthropometric, endocrine andneuroradiological assessment. Due to their GH dependency and relative stability in circulation,IGF-I and IGFBP-3 serum...
Book Chapter
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/000085762
EISBN: 978-3-318-01215-6
..., these studies have resulted in relatively few advances in therapy. Insulinlike-growth factor 1 (IGF-1) lowers blood glucose while at the same time lowering seruminsulin levels in normal volunteers. Its mechanism of action appears to be independent ofactivation of the insulin receptor although the role of IGF-1...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 24
Published: 07 July 1999
10.1159/000061012
EISBN: 978-3-318-00393-2