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Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102453
EISBN: 978-3-318-01467-9
... galactose from UDP-Gal to terminal GlcNAc of N- and O-glycans in a Β-1,4-linkage, developed IgA nephropathy (IgAN)-like disease. Urinary albumin levels were significantlyincreased in the Β4GalT-I-deficient mice. Hematuria was detected in some of theΒ4GalT-I-deficient mice, suggesting impaired renal function...
Book Chapter
Book Chapter
Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102283
EISBN: 978-3-318-01467-9
... to enter into clinical intervention trials, as well as making it harder to chooseappropriate therapy in individual patients. The International IgA Nephropathy Network[www.igan-world.org], working with members of the Renal Pathology Society, has establishedan international working group which is developing...
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102306
EISBN: 978-3-318-01467-9
... Abstract The pathogenesis of IgA nephropathy (IgAN) involves the deposition of aberrant glycosylatedIgA1 and/or of IgA1-immune complexes (IC) in the glomerular mesangium. Themechanisms involved in the generation of IgA1-IC and how they are deposited in themesangium are just emerging. We propose...
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102315
EISBN: 978-3-318-01467-9
... Abstract IgA is a glycoprotein with multiple O-glycans. Under-O-glycosylation of the hinge in IgAin patients with IgA nephropathy (IgAN) is reported. The development of IgAN is frequentlypreceded by episodes of upper respiratory tract infections such as tonsillitis. Therefore, thetonsils may...
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102456
EISBN: 978-3-318-01467-9
... Abstract Background: Post-methicillin-resistant Staphylococcus aureus infection glomerulonephritis(post-MRSA infection GN) is seen after MRSA infection and is a similar disorderto IgA nephropathy (IgAN). We have found that immune complexes composed of staphylococcalcell membrane antigen and IgA...
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102459
EISBN: 978-3-318-01467-9
... Abstract IgA Fc receptor I, FcαRI or CD89, an ITAM-bearing receptor, has revealed uniquegenetic, structure and function features among immunoreceptors. While all genes encodingfor the human Fc receptors are located in chromosome 1, the FcαRI gene has been found ina cluster in 19q13...
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Book Chapter
Series: Contributions to Nephrology
Volume: 190
Published: 29 May 2017
10.1159/000468955
EISBN: 978-3-318-06061-4
... Abstract IgA nephropathy (IgAN) is the most common primary glomerulonephritis in developed countries and a leading cause of chronic kidney disease. IgAN is a mesangial proliferative glomerulonephritis characterized by diffuse mesangial deposition of IgA, often accompanied by the deposition...
Book Chapter
Series: Contributions to Nephrology
Volume: 181
Published: 13 May 2013
10.1159/000348461
EISBN: 978-3-318-02390-9
... Abstract IgA nephropathy (IgAN) encompasses different pathological entities, all of which are characterized by the mesangial deposition of IgA. Aberrantly glycosylated IgA molecules appear to play a major role in the pathogenesis of IgAN. Both genetic and environmental factors contribute...
Book Chapter
Series: Contributions to Nephrology
Volume: 181
Published: 13 May 2013
10.1159/000348652
EISBN: 978-3-318-02390-9
... Abstract Primary IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. It is most common in Asian populations, followed by Caucasians, yet relatively infrequent amongst African populations. The striking difference in the prevalence of IgAN between world populations...