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hypospadia

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Book Chapter
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/000363662
EISBN: 978-3-318-02559-0
... Abstract What little data exist as to the optimal timing of hypospadias reconstruction is based on retrospective studies and expert opinion. No data exist as to the optimum timing of hypospadias reconstruction in the extremely small subset of patients with severe hypospadias that merits...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
EISBN: 978-3-318-02559-0
...: Timing of elective hypospadias repair in children. Pediatrics 1983;71:342-351. 3. The timing of elective surgery on the genitalia of male children with particular reference to undescended testes and hypospadias. Pediatrics 1975;56:479-483. 4. Tekgül S, Riedmiller H, Gerharz E, et al: Guidelines...
Book Chapter
Published: 17 August 2012
EISBN: 978-3-8055-9930-6
...: Is hypospadias a genetic, endocrine or environmental disease, or still an unexplained malformation?. Int J Androl 2009;32:187-197 9. Schnack TH, Zdravcovic S, Myrup C, et al: Familial aggregation of hypospadias: a cohort study. Am J Epidemiol 2008;167:251-256 10. Moreno-Garcia M, Miranda EB: Chromosomal...
Book Chapter
Published: 17 August 2012
10.1159/000336329
EISBN: 978-3-8055-9930-6
..., Philibert P, Sultan C: Is hypospadias a genetic, endocrine or environmental disease, or still an unexplained malformation?. Int J Androl 2009;32:187-197 9. Schnack TH, Zdravcovic S, Myrup C, et al: Familial aggregation of hypospadias: a cohort study. Am J Epidemiol 2008;167:251-256 10. Moreno-Garcia...
Book Chapter
Series: Endocrine Development
Volume: 22
Published: 30 July 2012
EISBN: 978-3-8055-9337-3
... 33. Fukami M, Wada Y, Miyabayashi K, Nishino I, Hasegawa T, Nordenskjold A, Camerino G, Kretz C, Buj-Bello A, Laporte J, Yamada G, Morohashi K, Ogata T: CXorf6 is a causative gene for hypospadias. Nat Genet 2006;38:1369-1371 34. Kalfa N, Liu B, Klein O, Audran F, Wang MH, Mei C, Sultan C, Baskin...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/000363666
EISBN: 978-3-318-02559-0
... hypothalamus-pituitary-testicular axis) [for a full overview, see [ 9 , 10 ]]. An isolated micropenis seems to occur more commonly with gonadotropin deficiency, whereas those associated with a lack of testosterone are often accompanied by hypospadias and/or undescended testes, suggesting normal placental human...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
EISBN: 978-3-318-02559-0
... masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest 2008;118:1479-1490. 19. Hsieh M, Eisenberg M, Hittelman A, Wilson J, Tasian G, Baskin L: Caucasian male infants and boys with hypospadias exhibit reduced anogenital distance. Hum Reprod 2012;27:1577-1580. 20...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/000363609
EISBN: 978-3-318-02559-0
... models in which androgens must act to masculinize all components of the reproductive tract and allow their later complete development. Impaired androgen action only within this MPW can induce cryptorchidism and hypospadias. This MPW is likely to occur between 8-14 weeks' gestation in humans. Studies...
Book Chapter
Series: Endocrine Development
Volume: 22
Published: 30 July 2012
10.1159/000326631
EISBN: 978-3-8055-9337-3
... on the underside of the penis (hypospadias) or a single perineal orifice at the base of the genital bud, between the genital ridges gonads that are impalpable or palpable in the inguinal position. In other cases the malformation is less clear cut and attention should be focused on: bilateral...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
EISBN: 978-3-318-02559-0
...-term outcome of vaginal reconstruction: comparing techniques and timing. J Pediatr Urol 2007;3:316-320. 15. Woodhouse CR, Christie D: Nonsurgical factors in the success of hypospadias repair. BJU Int 2005;96:22-27. 16. Schonbucher VB, Weber DM, Landolt MA: Psychosocial adjustment, health...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/000363665
EISBN: 978-3-318-02559-0
... was observed after early surgery, but secondary interventions were minor procedures, such as vaginal dilations. Analogies to Clinical Practice in Boys with Hypospadias It is widely believed that early genital surgery can avoid psychological trauma and associated adverse effects on body image in boys...
Book Chapter
Series: Endocrine Development
Volume: 14
Published: 26 February 2009
10.1159/000207485
EISBN: 978-3-8055-9042-6
... Abstract Cryptorchidism is part of the testicular dysgenesis syndrome (TDS), which includes other male reproductive disorders such as hypospadias, testis cancer and reduced semen quality. These diseases appear to be linked by common pathogenic mechanisms, interfering with normal fetal testis...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/000363633
EISBN: 978-3-318-02559-0
... gonad size, whereas impaired Leydig cell function is associated with hypotrophic Wolffian derivatives and ambiguous external genitalia, including hypospadias [ 9 ]. Pubertal development may be partial, requiring testosterone replacement. Most patients are infertile due to the primary hypogonadism...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321213
EISBN: 978-3-8055-9644-2
... hypospadias with undescended testes. Therefore, the human gonad appears to be more sensitive than the adrenal gland to loss of SF-1 function. This review will focus on the expanding range of phenotypes associated with DAX-1 and SF-1 mutations. The human adrenal gland first develops from an area...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321215
EISBN: 978-3-8055-9644-2
..., XY patients also a disorder of sex development is prevalent with hypospadias to complete female phenotype. P450scc deficiency is the differential diagnosis of congenital lipoid adrenal hyperplasia caused by mutations in the steroidogenic acute regulatory protein, however, in contrast to the latter...
Book Chapter
Series: Yearbook of Pediatric Endocrinology
Published: 14 September 2011
10.1159/000330947
EISBN: 978-3-8055-9860-6
.... Common variants in DGKK are strongly associated with risk of hypospadias Van der Zanden LF, van Rooij IA, Feitz WF, Knight J, Donders AR, Renkema KY, Bongers EM, Vermeulen SH, Kiemeney LA, Veltman JA, Arias-Vasquez A, Zhang X, Markljung E, Qiao L, Baskin LS, Nordenskjold A, Roeleveld N, Franke B...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
EISBN: 978-3-318-02559-0
...: Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest 2008;118:1479-1490. 6. Reyes FI, Winter JS, Faiman C: Studies on human sexual development. I. Fetal gonadal and adrenal sex steroids. J Clin...
Book
Book Cover Image
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/isbn.978-3-318-02559-0
EISBN: 978-3-318-02559-0
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
EISBN: 978-3-318-02559-0
... for care providers. Adv Urol 2012;2012:604135. 7. Ahmed SF, Dobbie R, Finlayson AR, Gilbert J, Youngson G, Chalmers J, Stone D: Prevalence of hypospadias and other genital anomalies among singleton births, 1988-1997, in Scotland. Arch Dis Child Fetal Neonatal Ed 2004;89:F149-F151. 8. Thyen U, Lanz...