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hydrocortisone

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Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
10.1159/000439329
EISBN: 978-3-318-05637-2
... cortisol deficiency, conventional hydrocortisone replacement treatment is still inadequate. A major limitation is that it fails to replace cortisol in a physiological manner. Cortisol has a distinct circadian rhythm and acts as a secondary messenger synchronizing the central to peripheral clocks, hence...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/000363752
EISBN: 978-3-318-02559-0
... hydrocortisone. The combination of enlarged adrenal glands in a patient with ambiguous genitalia was described for the first time in 1865 by De Cecchio in Italy, and has been described numerous times since then. Although the treatment of adult Addison syndrome with extracts from adrenal glands...
Book Chapter
Published: 30 October 1991
10.1159/000419884
EISBN: 978-3-318-05207-7
Book Chapter
Published: 30 October 1991
10.1159/000419885
EISBN: 978-3-318-05207-7
Book Chapter
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Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
EISBN: 978-3-318-05637-2
...References References 1. Stratmann M, Schibler U: Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J Biol Rhythms 2006;21:494-506. 2. Debono M, Ghobadi C, Rostami-Hodjegan A, et al: Modified-release hydrocortisone to provide circadian cortisol...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321241
EISBN: 978-3-8055-9644-2
... hydrocortisone replacement. Using Chronocort, a modified release preparation of hydrocortisone, we have demonstrated that it is possible to simulate the overnight rise in cortisol release and, in preliminary studies in patients with congenital adrenal hyperplasia, control morning androgen levels. Future studies...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
EISBN: 978-3-318-02559-0
.... Falhammar H, Nystrom HF, Thoren M: Quality of life, social situation, and sexual satisfaction, in adult males with congenital adrenal hyperplasia. Endocrine 2014, Epub ahead of print. 13. Bleicken B, et al: Influence of hydrocortisone dosage scheme on health-related quality of life in patients...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 49
Published: 26 April 2018
EISBN: 978-3-318-06335-6
..., Arnqvist HJ: A randomized, double-blind, crossover study comparing two- and four-dose hydrocortisone regimen with regard to quality of life, cortisol and ACTH profiles in patients with primary adrenal insufficiency. Clin Endocrinol (Oxf) 2012;77:18-25. 9. Barbetta L, Dall'Asta C, Re T, Libe R, Costa E...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
EISBN: 978-3-8055-9644-2
... DP, Arlt W, Ross RJ: Modified- release hydrocortisone to provide circadian cortisol profiles. J Clin Endocrinol Metab 2009;94:1548-1554 3. Born J, Hansen K, Marshall L, Molle M, Fehm HL: Timing the end of nocturnal sleep. Nature 1999;397:29-30 4. Buckley TM, Schatzberg AF: On the interactions...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 46
Published: 23 May 2016
10.1159/000443918
EISBN: 978-3-318-05840-6
... In the light of the observed impairment of QoL, current treatment concepts have been revisited. Special attention has been paid to the nonphysiological glucocorticoid profile achieved by the available standard replacement therapy. The short half-life of oral hydrocortisone requires repeated dosing with peaks...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 46
Published: 23 May 2016
EISBN: 978-3-318-05840-6
.... Endokrynol Pol 2010;61:90-92. 12. Bleicken B, Hahner S, Loeffler M, Ventz M, Decker O, Allolio B, Quinkler M: Influence of hydrocortisone dosage scheme on health-related quality of life in patients with adrenal insufficiency. Clin Endocrinol (Oxf) 2010;72:297-304. 13. Tiemensma J, Andela CD, Pereira...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 46
Published: 23 May 2016
EISBN: 978-3-318-05840-6
..., Skrtic S: Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation. J Clin Endocrinol Metab 2012;97:473-481. 3. Løvås K, Loge JH, Husebye ES: Subjective health status in Norwegian...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 43
Published: 12 June 2014
10.1159/000360556
EISBN: 978-3-318-02674-0
... treatment introduced for AI in 1938. Prior to its introduction, the 2-year mortality in patients with Addison's disease was estimated to exceed 80% [ 15 ]. Soon after the discovery of cortisone by Hench, Kendall and Reichstein in 1948, hydrocortisone became commercially available [ 16 ]. For replacement...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 49
Published: 26 April 2018
10.1159/000486004
EISBN: 978-3-318-06335-6
... to resume daily life activities including full working capacity and restored quality of life without serious side effects. The most commonly used glucocorticoids are hydrocortisone (HC) and cortisone acetate (CA). The latter is activated to cortisol by 11-beta-hydroxysteroid dehydrogenase type 1...