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Book Chapter
Published: 05 December 1990
10.1159/000419694
EISBN: 978-3-318-05025-7
... Abstract We have studied the effects of pentoxifylline and HWA 138 on the production of tumor necrosis factor (TNF) and interleukin 6 (IL-6) from human monocytes and the murine macrophage cell line RAW 264.7. TNF and IL-6 were quantitated by bioassays based on the cell lines WEHI 164 clone 13...
Book Chapter
Published: 05 December 1990
10.1159/000419698
EISBN: 978-3-318-05025-7
... Abstract We studied the effect of HWA 138, an analogue of pentoxifylline, in awake adult sheep receiving a continuous infusion of E. coli endotoxin. In 5 control untreated animals, endotoxin produced a state of shock characterized by a decreased cardiac output (CO), an increased pulmonary...
Book Chapter
Published: 05 December 1990
10.1159/000419699
EISBN: 978-3-318-05025-7
.... In addition, we evaluated the possible protective effects of pentoxifylline (PTXF), aminophylline (AMPH), HWA 138, an analogue of pentoxifylline, and dibutyryl cyclic AMP (DBcAMP) on acute lung injury in E. coli-, TNF-, and IL-2-treated guinea pigs. We also investigated the possible protection PTXF may afford...
Book Chapter
Published: 05 December 1990
10.1159/000419700
EISBN: 978-3-318-05025-7
...) decreased to a minimum after about 24 hours and recovered to normal levels after 48 hours. AT III decrease could also be induced by the direct administration of PMN-elastcse. We evaluated whether the xanthine derivative HWA 138 (Hoechst Werk Albert, Wiesbaden) would influence the LPS-induced decrease...
Book Chapter
Published: 05 December 1990
10.1159/000419701
EISBN: 978-3-318-05025-7
... Abstract The xanthine derivative pentoxifylline (PTX, Trental®) and its metabolically more stable structural analogs, HWA 138 and HWA 448 were compared in their capacity to inhibit the formation of tumor necrosis factor in mice and macrophage cultures and to prevent leukopenia in mice provoked...
Book Chapter
Published: 05 December 1990
10.1159/000419691
EISBN: 978-3-318-05025-7
... on the effects of metabolites, BL-194 (metabolite 1) and A81 3138, and analog HWA 448 on the actin state in neutrophils. The reduction in F-actin content in neutrophils was 13 %, 32 %, 34 % and 40 % for A81 3138, pentoxifylline, BL-194 and HWA 448, respectively, at a concentration of 10 mM of each drug. Since...
Book Chapter
Published: 05 December 1990
10.1159/000419704
EISBN: 978-3-318-05025-7
... by PAF. But pentoxifylline and acetylsalicylic acid, administered sequentially in an interval of 15 minutes (principle of HWA 5112) were also able to hinder pulmonary platelet embolism. Treatment of the animals with pentoxifylline and HWA 138, as well as with other xanthine derivatives, reduced LPS...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
EISBN: 978-3-318-02268-1
...References References 1. Savage MO, Attie KM, David A, Metherell LA, Clark AJ, Camacho-Hübner C: Endocrine assessment, molecular characterization and treatment of growth hormone insensitivity disorders. Nat Clin Pract Endocrinol Metab 2006;2:395-407 2. Kofoed EM, Hwa V, Little B, Woods KA...
Book Chapter
Published: 05 December 1990
10.1159/000419680
EISBN: 978-3-318-05025-7
... Abstract Incubation of human neutrophils (PIN) in vitro with recombinant human tumor necrosis factor (rhTNF), decreased PMN non-directed and directed migration. The alkylxanthines, rentoxifylline (RTX), and the PTX derivate HWA 138 [1-(5-hydroxy-5methylhexyl)-3-methylxanthine] restored-TNF...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342586
EISBN: 978-3-318-02268-1
... Endocrinol Metab 2006;2:395-407 2. Kofoed EM, Hwa V, Little B, Woods KA, Buckway CK, Tsubaki J, Pratt KL, Bezrodnik L, Jasper H, Tepper A, Heinrich J, Rosenfeld RG: Growth-hormone insensitivity (GHI) associated with a STAT-5b mutation. N Engl J Med 2003;349:1139-1147 3. Hwa V, Nadeau K, Wit JM...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 71
Published: 24 January 2013
10.1159/000342548
EISBN: 978-3-318-02270-4
...) and type I IGF receptor (Igflr). Cell 1993;75:59-72 9. Laron Z, Pertzelan A, Mannheimer S: Genetic pituitary dwarfism with high serum concentation of growth hormone - a new inborn error of metabolism?. Isr J Med Sci 1966;2:152-155 10. David A, Hwa V, Metherell LA, et al: Evidence for a continuum...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
EISBN: 978-3-318-02245-2
... in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty. Eur J Endocrinol 2011;165:233-241 9. Mullis PE: Genetics of GHRH, GHRH-receptor, GH and GH-receptor: its impact on pharmacogenetics. Best Pract Res Clin Endocrinol Metab 2011;25:25-41 10. David A, Hwa V...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 71
Published: 24 January 2013
EISBN: 978-3-318-02270-4
... A, Hwa V, Metherell LA, et al: Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity. Endocr Rev 2011;32:472-497 11. Ayling RM, Ross R, Towner P, et al: A dominant-negative mutation of the growth hormone receptor causes familial...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
EISBN: 978-3-318-02268-1
..., Scaglia P, Heinrich JJ, Jasper HG: Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene. N Engl J Med 2004;350:570-577 12. David A, Hwa V, Metherell LA, Netchine I, Camacho-Hübner C, Clark AJL, Rosenfeld RG, Savage MO: Evidence...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 106
Published: 12 February 2013
EISBN: 978-3-318-02266-7
...References References 1. de Onis M, Monteriro C, Akré J, Clugston G: The worldwide magnitude of protein-energy malnutrition: an overview from the WHO global database on child growth. Bull WHO 1993;71:703-712 2. David A, Hwa V, Metherell LA, Netchine I, Camacho-Hübner C, Clark AJL...
Book Chapter
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Published: 05 December 1990
10.1159/isbn.978-3-318-05025-7
EISBN: 978-3-318-05025-7
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
EISBN: 978-3-318-02268-1
... study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth. J Clin Endocrinol Metab 2004;89:384-391 16. Fuqua JS, Derr M, Rosenfeld RG, Hwa V: Identification of a novel heterozygous...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 65
Published: 11 February 2010
EISBN: 978-3-8055-9305-2
... homology with insulin B chain. Proc Natl Acad Sci USA 1976;73:4379-4381 8. Udy GB, Towers RP, Snell RG, et al: Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 1997;94:7239-7244 9. Kofoed EM, Hwa V, Little B, et al: Growth hormone...
Book Chapter