... Abstract High plasma concentrations of the amino acid homocysteine have been associatedwith atherothrombotic disease, first in individuals with inborn errors of homocysteinemetabolism, who have very high plasma homocysteine concentrations, and later also inthe general population. In general...

... endogenous methyl donor. Stable isotope tracer studies in young healthy volunteers show that almost 100% of the methyl groups used for whole body remethylation of homocysteine are derived from serine under the conditions of their study [ 5 ]. The latter is important, since the tracer studies were done after...

... B 12 , folic acid and homocysteine. Substantial nutritional deficiencies in these three vitamins along with mild hyperhomocysteinemia, perhaps through an interplay with the classical cardiovascular risk factors (highly prevalent in this population), could further aggravate the risk of coronary...

..., Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 1995;274:1049-1057 3. Bramly S: Leonardo: Discovering the Life of Leonardo da Vinci (Reynolds S: English translation). Staten Island, Brainiac Books, 1991; 4. BrattstrÖm LE: Vitamins...

.... Davis SR, Stacpoole PW, Williamson J, et al: Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am J Physiol Endocrinol Metab 2004;286:E272-E279. 6. Brosnan JT, Hall B: Renal serine production in vivo...

... Indians. J Assoc Physicians India 2006;54:775–782. 9. Yajnik CS, Chandak GR, Joglekar C, et al: Maternal homocysteine in pregnancy and offspring birthweight: epidemiological associations and Mendelian randomization analysis. Int J Epidemiol 2014;43:e1487–e1497. 10. Yajnik CS, Deshpande SS, Jackson...

... a higher affinity for the folate receptor and could overstimulate the receptor or competitively inhibit natural folates from interacting with the receptor, with consequent ill effects. B12 Studies in India Our interest in vitamin B12 started when we serendipitously investigated homocysteine...

... with folate is at present feasible and ethically correctand is already in progress at our institution. Homocysteine levels in cancer patients are probablylargely affected by the HNSCC phenotype. An accumulation of homocysteine mightreveal a genetic defect which is theoretically a target for pharmacological...

... responsiveness to estrogen, particularly at lower doses, is related topolymorphisms in the estrogen receptor-α gene. Recently, circulating homocysteine levelshave been shown to be associated with fracture risk. Folate and vitamin B supplements forreducing serum homocysteine and fractures in postmenopausal women...

... during chronic therapy.This deficiency may lead to increased plasma homocysteine levels which, in turn,accelerate the progression of vascular disease due to adverse effects on platelets, clottingfactors, and endothelium. The existence of a graded association between homocysteine levelsand overall...

... elevated methylmalonic acid levels, and both B 12 deficiency and folate deficiency cause elevated homocysteine levels. Introduction Anemia is defined as hemoglobin (Hgb) less than 13 g/dl for males and 12 g/dl for females. There are many factors influencing Hgb such as sex, age, race, altitude...

...References References 1. Chaudhry V, Umapathi T, Ravich WJ: Neuromuscular diseases and disorders of the alimentary system. Muscle Nerve 2002;25:768-784. 2. Carmel R, Green R, Rosenblatt DS, Watkins D: Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program...

... homocysteine concentration and neonatal size in India. Asia Pac J Clin Nutr 2005;14:179-181. 7. Muthayya S, Kurpad AV, Duggan CP, et al: Low maternal vitamin B 12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr 2006;60:791-801. 8. Bhate V, Deshpande S...

... cholesterol, eggs and coronary heart disease risk in perspective. Br Nutr Found Nutr Bull 2006;31:21-27 31. Chiuve SE, et al: The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr 2007;86:1073-1081 32. Konstantinova SV, et al...

... deficiency was rare. Higher circulating concentrations of homocysteine predicted smaller baby size. Follow-up studies revealed that higher maternal folate in pregnancy predicted higher adiposity and insulin resistance in the child at 6 years of age, and that low maternal vitamin B 12 exaggerated the risk...

... on epigenetic regulation of gene expression were studied. Choline Metabolism Choline is involved in 3 major pathways: acetylcholine synthesis, methyl donation via betaine, and phosphatidylcholine synthesis [ 3 ]. Choline, via its irreversible oxidation to betaine [ 4 ], methylates homocysteine to form...

... and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994;96:239-246. 7. Healton EB, Savage DG, Brust JC, et al: Neurologic aspects of cobalamin deficiency. Medicine 1991;70:229-245. 8. Kuzminski AM, Del Giacco EJ, Allen RH, et al: Effective treatment...