Search Results for hla

... Abstract Celiac disease (CD) is a multifactorial disorder in which thecombination of several genetic factors together with anenvironmental trigger is necessary for development of thedisease. Genetic predisposition to CD is complex andincludes the HLA-DQA1*05/ DQB1*02 and HLA-DQA*0301/DQB*0302...

... weeks posttransplant). The advent of more sensible and specific techniques of detection of anti-HLA antibodies (such as ELISA or Luminex techniques) has questioned this dogma, with a number of reports showing that transplantation, despite the presence of an donor-specific antibody (DSA), could be done...

... and inflammatory disorders. Rituximab (anti-CD20, anti-B-cell monoclonal antibody) has also shown efficacy in the treatment of autoimmune and inflam-matory disorders. We have recently described a beneficial effect of the combination of IVIG + rituximab on the reduction of anti-human leukocyte antigen (HLA...

... Abstract Numerous retrospective and prospective studies have been conducted to determine the prevalence and significance on long-term graft survival of de novo post-transplant donor-specific antibodies (DSA), directed against both HLA and non-HLA molecules. Moreover, it has been postulated...

... Abstract Patients undergoing renal transplantation frequently have non-donor-specific HLA antibodies (NDSA). There could be NDSA (e.g. a negative crossmatch in a sensitized patient), or could be donor-specific HLA antibodies (DSA) (e.g., antibody-incompatible transplantation). NDSA levels...

... Abstract Antibodies and B cells are increasingly recognized as major modulators of allograft function and survival. Improved immunohistochemical and serologic diagnostic procedures have been developed to monitor antibody responses against HLA antigens during the last decade. Acute and chronic...

... invading the decidua basalis in early pregnancy expresses thepolymorphic HLA-C, and nonpolymorphic HLA-E and HLA-G molecules that can interactwith specific HLA class I-dependent dNK receptors, including the immunoglobulin-like KIRs,the lectin-like CD94/NKG2 and the CD160 receptors. There is no clear...