... Abstract Histamine influences several immune/inflammatory and effector functions in addition to its dominant role in type I hypersensitivity reactions. Histamine can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization, and other...

... antigens by sweat induces acute allergic reactions and that sweating functions of AD patients via axonal reflexes are decreased. Histamine demonstrably inhibits acetylcholine-induced sweating in both mice and humans via histamine H 1 receptor-mediated signaling. In sweat glands, acetylcholine inactivates...

... Abstract The synthesis and the identification of histamine marked a milestone in both pharmacological and immunological research. Since Sir Henry Dale and Patrick Laidlaw described some of its physiological effects in vivo in 1910, histamine has been shown to play a key role in the control...

...The target The recent discovery of a fourth receptor for histamine, histamine H 4 (H 4 R), has rekindled an interest in histamine as a potentially important mediator of asthma and other allergic diseases that are refractory to conventional antihistamine therapy. Traditionally, histamine has...

... Abstract Histamine is not only the major mediator of the acute inflammatory and immediatehypersensitivity responses, but has also been demonstrated to affect chronic inflammationand regulate several essential events in the immune response. It can influence numerousfunctions of the cells...