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hemoperfusion

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Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527774
EISBN: 978-3-318-07124-5
... Abstract Direct hemoperfusion with the CytoSorb® adsorbent has experienced widespread use in several critical care settings including sepsis and multiorgan failure. The reported conditions of clinical usage and resulting outcomes vary considerably. The aim of the study was to provide...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000529294
EISBN: 978-3-318-07124-5
... Abstract Recent advances in the development of sorbent materials have enabled the development of hemoperfusion (HP). However, HP dose and prescription are not standardized and there is no consensus in clinical practice guidelines. Adequate prescription and modality are of utmost importance...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527953
EISBN: 978-3-318-07124-5
... of hemoperfusion with HD at least in a session per week. These studies need further confirmation, but they may represent the doorway to further improve patient’s outcome in maintenance dialysis. Abstract Despite advances in dialysis technology, a high level of morbidity and mortality is still present...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000529885
EISBN: 978-3-318-07124-5
... Abstract Recent development in sorbent technology has spurred new interest in the potential of hemoperfusion (HP) in clinical conditions such as cytokine release syndromes and sepsis. Although the role of nonselective HP in such conditions requires solid evidence and more studies, the rationale...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527570
EISBN: 978-3-318-07124-5
... (DAMPs) after traumatic and ischemic tissue injury. These trigger a vicious cycle of overactive pro- and anti-inflammatory pathways, leading to organ dysfunction and immunoparesis. Extracorporeal hemoperfusion, with its ability to adsorb both DAMPs and inflammatory mediators from the bloodstream, has...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527338
EISBN: 978-3-318-07124-5
.... Hemoperfusion is a blood purification technique, which relies on mass separation by a solid agent (hemoadsorption). It can be performed by adding a cartridge filled with adsorptive sorbent in the extracorporeal circuit. These devices have the theoretical advantage to enable the removal of excess pro- and anti...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527583
EISBN: 978-3-318-07124-5
... the effectiveness and risk of various hemoperfusion techniques in the context of severe SARS-CoV-2 infection including HA330, CytoSorb, Polymyxin, oXiris, and Seraph 100 cartridges. Because inconsistencies exist between studies, there is currently no consensus regarding the use of hemoperfusion in patients...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527571
EISBN: 978-3-318-07124-5
... cyclophosphamide. In some patients, however, hemodynamic collapse and acute respiratory distress syndrome ensue, which may be due to the release of cytokines resulting from the dysregulated immune response. Blood purification in the form of hemoperfusion (HP) with neutral macroporous resin-adsorbing beads adsorbs...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527709
EISBN: 978-3-318-07124-5
... support, and increased mortality. To date, several strategies, such as hemoperfusion techniques, have been developed to mitigate immune activation. We propose herein a review of the immune response to burn injury and the rationale and potential applications of extracorporeal blood purification techniques...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000526730
EISBN: 978-3-318-07124-5
... Abstract Hemoperfusion (HP) is an extracorporeal blood purification therapy that is used to remove poisons or drugs from the body. This chapter provides a brief overview of the technical aspects and the potential indications and limitations of HP, with the focus being on the use of HP for acute...
Book Chapter
Series: Contributions to Nephrology
Volume: 196
Published: 09 August 2018
10.1159/000485725
EISBN: 978-3-318-06298-4
... several years. Summary: To date, 3 multicenter RCTs on PMX hemoperfusion have been conducted outside of Japan. All of them enrolled postoperative patients with sepsis or septic shock secondary to intra-abdominal infection. However, confidence in the level of evidence provided by these RCTs is very low...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315921
EISBN: 978-3-8055-9485-1
..., and is thus an ideal potential therapeutic target. Direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-F) has been shown to bind and neutralize endotoxin in both in vitro and in vivo studies. Therefore, this extracorporeal therapy with PMX-F can potentially interrupt the biological cascade...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315923
EISBN: 978-3-8055-9485-1
... Abstract Background: We evaluated the ability of the endotoxin activity (EA) assay to determine the need for early intervention for endotoxemia using polymyxin B-based hemoperfusion (PMX-DHP) on septic patients. Methods: Twenty-four patients were enrolled. Eleven patients had a high EA...
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