... Abstract Aging leads to functional decline of hematopoietic stem cells (HSCs), including alterations of self-renewal and differentiation, which is thought to contribute to age-related hematopoietic disorders, defects in immune functions, and an increase in hematopoietic malignancies. Different...

... Abstract Two years ago, during the first symposium of the Else Kröner-Fresenius Foundation, the conceptual view of hematopoietic stem cells (HSCs) was in the process of changing. It was long assumed that HSCs equivalently give rise to all lymphoid and myeloid cells. However, many key papers...

... Abstract The following section will provide an overview of the current data and theories on aging of hematopoietic stem cells (HSCs). Aging is characterized by a gradual loss of regenerative capacity to sufficiently maintain tissue homeostasis and organ integrity. Mounting evidence suggests...

... Abstract Hematopoietic stem cell transplantation (HSCT) has evolved over the last half century from experimental bone marrow transplantation for patients with incurable leukemia or bone marrow failure to standard of care for a broad range of patients with congenital or acquired disorders...

... Abstract Today, long-term prognosis after hematopoietic stem cell transplantation (HSCT) has greatly improved. Nevertheless, there are still a number of malignant and nonmalignant late effects that can cause substantial morbidity, with considerable impact on the health status and quality...

... hypersensitivity syndromes or anaphylaxis. Cutaneous manifestations, particularly maculopapular exanthemas have a high incidence among patients treated with hematopoietic stem cell transplantation. In many cases, a virus- or drug-induced origin or a combination of both is responsible. However, the transplantation...

... Abstract The procedure of hematopoietic stem cell transplantation (HSCT) will keep expanding over the next decades. The list of indications for autologous or allogeneic HSCT of nonmalignant and malignant hematological disorders will grow. Other life-threatening diseases such as genetic...

... Abstract The following section will give an overview of the current data and theories on the aging of hematopoietic stem cells (HSCs). Aging is characterized by a gradual loss of regenerative capacity to sufficiently maintain tissue homeostasis and organ integrity. Mounting evidence suggests...

... Abstract This chapter summarizes current data indicating how aging of hematopoietic stem cells and the stem cell environment can contribute to leukemia development and progression. Cancer arises through the progressive genetic and epigenetic alterations of normal cells, and according...

... Abstract Following the first successful allogeneic hematopoietic cell transplant (HCT) procedures in 1968, the cumulativenumber of patients treated with HCT has now risen to approximately 850,000 worldwide. Greatstrides have been made during the past four decades to overcome the major obstacles...

... megakaryocytes (MK) through adynamic process, called proplatelet formation. MK themselves are generated through different biologicaland cellular steps that include the commitment of hematopoietic stem cells towards MK progenitors, theproliferation of MK progenitors, their polyploidization and terminal maturation...