... Abstract Haematopoietic cell transplantation (HCT) is a recognised curative approach for children and adults affected by malignant and non-malignant haematological disorders. Nevertheless, myeloablative preparative regimens are associated with significant short-term toxicity and long-term...

... Abstract Following the first successful allogeneic hematopoietic cell transplant (HCT) procedures in 1968, the cumulativenumber of patients treated with HCT has now risen to approximately 850,000 worldwide. Greatstrides have been made during the past four decades to overcome the major obstacles...

... products (HCT/Ps). There is also a guideline on the production and development of stem cell therapies consisting of several reference documents [ 3 , 5 , 13 ]. Human cell-based products are regulated under three different sections of the US Public Health Service in the Code of Federal Regulations (CFR...

...). Interestingly, the model generated using these variables kept its predictive value for TRM even when age was withdrawn, indicating that age should be viewed as a surrogate for many other variables [ 30 ]. Comorbidities evaluated using HCT-CI and revised HCT-CI Table 3. Comorbidities evaluated using HCT...

... of sophistication and clinical relevance. Specifically, this model accounts for changes in hematocrit (Hct) and protein concentration ( C p ) as a function of position along the device. Based on the principle of mass conservation, the estimated changes in axial blood flow rate, Q b ( x ) and dialysate flow...

... relationship between flow resistance and r 4 , a small decrease in the inner diameter of the hollow fiber induces a large increase in flow resistance. Equation 3 also demonstrates that increases in fiber length and hematocrit (Hct; through an effect on blood viscosity) are associated with an increase in flow...

... were classified as frail and prefrail [ 32 ]. Significant risk factors could not be identified due to limited power, but increased odds ratios (ORs) were found for radiotherapy and smoking. Self-reported frailty was also evaluated in almost 1,000 young adult hematopoietic cell transplantation (HCT...

... differences in basal RBC count, hematocrit (Hct), blood Hb concentration, and mean corpuscular Hb concentration (MCHC) in athletes in comparison to nonathletes, but Hb mass is increased in elite endurance athletes [ 1 ]. In contrast, sportsmen, particularly those practicing endurance sports, may present...

....pdf. 14. Dietz AB, Padley DJ, Gastineau DA: Infrastructure development for human cell therapy translation. Clin Pharmacol Ther 2007;82:320-324. 15. Guidance for Industry: Regulation of human cells, tissues, and cellular and tissue-based products (HCT/Ps) - small entity compliance guide...

..., Storb R, et al: Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 2005;106:2912-2919 36. Sorror ML, Maris MB, Storer B, et al: Comparing morbidity and mortality of HLA-matched unrelated donor hematopoietic cell...

... coagulation and fibrinolytic factors and platelets. Here is the experiment data from the manufacturer (Fig. 2 ), a chart showing the sieving coefficient. The testing conditions are as follows: blood flow rate = 100 ± 2 ml/min; filtration rate = 30 ± 1 ml/min; blood from cows: TP = 6.0 ± 0.5 g/dL, Hct = 32...

... which use lower doses of radiation, the development of new anti-cancer therapies and hematopoietic cell transplant (HCT) protocols to attempt to reduce both acute and long-term toxicities [ 3 ]. Despite these efforts, patients treated for childhood cancers, particularly those who require surgery...