... Abstract Reproductive hormones play a role at all stages of life and affect most tissues of the body. Gonadotropin-releasing hormone (GnRH) synthesized in the hypothalamus stimulates the secretion of gonadotropins which in turn stimulate gonadal sex hormone production and gamete formation...

... Abstract Depot gonadotropin-releasing hormone (GnRH) analogs represent the first-line therapy in sexual precocity due to central precocious puberty. GnRH analogs desensitize the pituitary and account for the suppression of luteinizing hormone and follicle-stimulating hormone leading...

...New geneThe most obvious candidate gene in gonadotropic deficiency validated at last Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a condition characterized by a failure to undergo puberty and normal fertility in adulthood. IHH is related to a defect of GnRH secretion or GnRH...

... receptor (GnRH-R) and associated proteins have evolvedas a central element. GnRH-R germline mutations were among the first genetic alterationsidentified in patients with IHH. These mutations are associated with impaired GnRH binding,ligand-induced signal transduction, or both, leading to various degrees...

... Abstract Reproductive function depends on the activity of the gonadotropic axis, which is controlled by a hypothalamic neural network whose main function is to regulate the secretion of gonadotropin-releasing hormone (GnRH). This endocrine network is not mature at birth, and several phases...

... to hypergonadotropic hypogonadism, whereas in subjects with HH, besides long-term testosterone, also gonadotropins and gonadotropin-releasing hormone (GnRH) can be used. Gonadotropins and GnRH, besides inducing secondary sexual characteristics, can also induce testicular maturation and spermatogenesis. Other molecules...

... or ‘chemical castration’ for some types of sexual offenders [ 1 ], but it is difficult for voluntary patients who wish to dampen their own sexual drives to find practitioners willing or able to prescribe hormonal treatment. Gonadotropin-releasing hormone (GnRH) agonists such as leuprolide acetate and related...

... - the cascade of events underlying the normal initiation ofpuberty. It is also proposed that because HHs contain key transcriptional and signalingnetworks required to initiate and sustain a pubertal mode of gonadotropin-releasing hormone(GnRH) release, they are able to trigger the pubertal process at an earlier...

... of 0.2% among girls and less than 0.05% among boys [ 2 ]. The most common mechanism of progressive precocious puberty is the early activation of pulsatile gonadotropin-release hormone (GnRH) secretion, resulting in central precocious puberty (CPP), also known as gonadotropin-dependent precocious...

... neuroendocrine standpoint, puberty begins when pulsatile gonadotropin-releasing hormone (GnRH) release from neurosecretory neurons of the hypothalamus increases in a diurnal fashion and for a sustained period of time, driving the pituitary gland to release more LH, also in a pulsatile fashion and with a diurnal...