Search Results for glutamate

... Abstract Neuroprogression is a term used to describe worsening psychopathology, poor treatment response, and declining cognitive and functional outcomes among patients with chronic mental disorders. Chronic inflammatory activation and glutamate-mediated excitotoxicity are two key etiological...

... on the monoamine neurotransmitters noradrenaline, 5-hydroxytryptamine (5-HT, serotonin), and dopamine and the amino acid neurotransmitters GABA (γ-aminobutyric acid) and glutamate in chronic pain and depression. Numerous preclinical and clinical neurochemical, neuroanatomical, pharmacological and molecular...

... Abstract This chapter reviews the structure and allosteric regulation of glutamate dehydrogenase (GDH). For decades, it was known that mammalian GDH was regulated by a wide array of metabolites, but the reason for such regulation was not at all clear. The demonstration that hyperinsulinism...

... Abstract Activating mutations of glutamate dehydrogenase (GDH) were first demonstrated in 1998 to be the cause of hyperinsulinism (HI) in children with an unusual phenotype of hyperinsulinemic hypoglycemia combined with persistent hyperammonemia (HA). These children are commonly not diagnosed...

... the mechanisms of amino acid-stimulated insulin secretion (AASIS), including activating mutations of glutamate dehydrogenase (GDH), inactivating mutations of the ATP-sensitive potassium channel [sulfonylurea receptor 1 (SUR1) and Kir 6.2], and inactivating mutations of short-chain 3-hydroxyacyl-CoA dehydrogenase...

... Abstract One of the genetic forms of hyperinsulinism highlights the role of glutamate dehydrogenase (GDH) in pancreatic beta-cells. GDH is a mitochondrial enzyme which plays a pivotal role between carbohydrate and protein metabolisms by controlling production and consumption of the messenger...

.... These findings have prompted vigorous investigation of the glutamate system as a central target for antidepressant drug discovery. In particular, there is now substantial initial evidence for rapid-onset antidepressant properties of the N-methyl-D-aspartate glutamate receptor antagonist ketamine. Ongoing...