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Book Chapter
Series: Frontiers of Hormone Research
Volume: 54
Published: 17 December 2021
10.1159/000515111
EISBN: 978-3-318-06791-0
... Abstract Growth hormone deficiency (GHD) is common in childhood cancer survivors (CCS). Major risk factors for GHD include radiation therapy, both cranial and total body irradiation, and tumor location. Some newer anti-cancer therapies may impact growth and the GH-IGF-1 axis as well. While...
Book Chapter
Series: Endocrine Development
Volume: 33
Published: 28 June 2018
10.1159/000487525
EISBN: 978-3-318-06143-7
.... Adolescents with childhood onset GH deficiency (GHD) show reduction of bone mineral density, decrease in lean body mass, increase in fat mass, and deterioration of the lipid profile. For this reason, continuation of GH replacement therapy in the transition age is recommended in all patients with a confirmed...
Book Chapter
Series: Frontiers in Diabetes
Volume: 22
Published: 10 April 2014
10.1159/000357243
EISBN: 978-3-318-02598-9
... Abstract Growth hormone (GH) deficiency (GHD) is a complex disease with a constellation of symptoms and signs which involve metabolism at several levels. Particular attention has been paid to glucose and insulin regulation by the GH and insulin-like growth factor 1 axis with contrasting results...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318503
EISBN: 978-3-8055-9445-5
... Abstract Growth hormone deficiency (GHD) in adults is a recognized syndrome which is defined biochemically within an appropriate clinical context. Clinically, patients investigated for GHD should include those with signs and symptoms of hypothalamic-pituitary disease, those who have received...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 49
Published: 26 April 2018
10.1159/000485997
EISBN: 978-3-318-06335-6
... , 11 , 12 , 13 ]. After the first data on excess mortality from cardio-vascular causes in adult patients with hypopituitarism, receiving conventional replacement without GH therapy, clinical efforts were made to define and replace GH deficiency (GHD) in adults as the major cause of MetS phenotype...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
10.1159/000341736
EISBN: 978-3-318-02245-2
... of neurohypophyseal functional integrity, has been the most striking development for the diagnosis and understanding of certain forms of ‘idiopathic’ and permanent growth hormone deficiency (GHD) [ 3 - 14 ]. However, these developments have inevitably raised some important questions. Is there a gold standard...
Book Chapter
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/000085758
EISBN: 978-3-318-01215-6
... Abstract In the current guidelines for the diagnosis of adult GH deficiency (GHD) it is statedthat, within the appropriate clinical context, it has to be shown by provocative tests only. Butthe diagnostic value of measuring IGF-I levels has been recently revisited. It has been confirmedthat...
Book Chapter
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/000085757
EISBN: 978-3-318-01215-6
... Abstract The diagnosis of growth hormone (GH) deficiency (GHD) in childhood is not straightforward,being still based on a comprehensive clinical, anthropometric, endocrine andneuroradiological assessment. Due to their GH dependency and relative stability in circulation,IGF-I and IGFBP-3 serum...
Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
10.1159/000439333
EISBN: 978-3-318-05637-2
... and subsequently purify growth hormone (GH) from cadaveric human pituitaries. However, its clinical use was restricted due to limited availability of supplies and the main beneficiaries were a limited number of children with GH deficiency (GHD). Many attempts to synthesize the human GH (hGH) protein failed until...
Book Chapter
Series: Endocrine Development
Volume: 14
Published: 26 February 2009
10.1159/000207481
EISBN: 978-3-8055-9042-6
... often related to a defect in cellular growth, but some unknown abnormality in GH action is possible. Recently, the greater availability of recombinant GH has expanded the interest towards GH secretion and therapy also in developmental syndromes. We recognize syndromes associated with GH deficiency (GHD...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 71
Published: 24 January 2013
10.1159/000342640
EISBN: 978-3-318-02270-4
... Abstract Although growth hormone (GH) therapy is virtually always effective in accelerating growth and restoring height potential to children with GH deficiency (GHD), the expansion of its use to a wide variety of other clinical disorders associated with short stature has resulted...
Book Chapter
Series: Endocrine Development
Volume: 11
Published: 20 November 2007
10.1159/000111055
EISBN: 978-3-8055-8348-0
... the interindividualvariability in response to GH in GH deficiency (GHD) and in short non-GHDsubjects. To this regard, genes coding for factors involved in GH action could play an importantrole. GH acts through the GH receptor (GHR), and therefore the GHR gene could be thefirst candidate to influence the response to GH...
Book Chapter
Series: Yearbook of Pediatric Endocrinology
Published: 13 September 2010
10.1159/000320662
EISBN: 978-3-8055-9602-2
... value of the glucagon test as an alternative to insulin tolerance test (ITT) and arginine test in children younger than 6 years with GHD as few studies have addressed the diagnostic role of the glucagon test in children when GH deficiency (GHD) is suspected. Methods: 48 children (median age 4.2...
Book
Book Cover Image
Series: Frontiers of Hormone Research
Volume: 33
Published: 29 September 2005
10.1159/isbn.978-3-318-01261-3
EISBN: 978-3-318-01261-3
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342575
EISBN: 978-3-318-02268-1
... Mutations Homozygous Phenotype All the patients with biallelic mutations present a similar phenotype characterized by a severe degree of GH deficiency (GHD). Because GH and GHRH are not necessary during fetal life, children have normal size at birth, and the growth retardation becomes evident during...
Book
Book Cover Image
Published: 27 April 2007
10.1159/isbn.978-3-318-01447-1
EISBN: 978-3-318-01447-1
Book Chapter
Series: Endocrine Development
Volume: 33
Published: 28 June 2018
EISBN: 978-3-318-06143-7
... or cessation of growth hormone (GH) therapy on body composition and metabolic status in adolescents with severe GH deficiency at completion of linear growth. J Clin Endocrinol Metab 2004;89:3890-3895. 9. Conway GS, Szarras-Czapnik M, Racz K, Keller A, Chanson P, Tauber M, Zacharin M; 1369 GHD to GHDA...
Book
Book Cover Image
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/isbn.978-3-318-01215-6
EISBN: 978-3-318-01215-6
Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
EISBN: 978-3-318-05637-2
... and efficacy results of a 6 month, randomized, multi-center trial of a novel long-acting rhGH (VRS-317) in naïve to treatment, pre-pubertal children with growth hormone deficiency (GHD) (abstract). 16th International Congress of Endocrinology and the Endocrine Society's 96th Annual Meeting and Expo (ICE/ENDO...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
EISBN: 978-3-318-02245-2
...: Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults. J Clin Endocrinol Metab 1999;84:1324-1328 14. Murray PG, Hague C, Fafoula O, Gleeson H, Patel L, Banerjee I, Raabe AL, Hall CM, Wright NB...