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Book Chapter
Series: Genome Dynamics
Volume: 1
Published: 27 March 2006
10.1159/000092496
EISBN: 978-3-318-01290-3
... Abstract In the past fifteen years, an emerging group of genetic diseases have been describedthat result from DNA rearrangements rather than from single nucleotide changes. Such conditionshave been referred to as genomic disorders. The predominant molecular mechanismunderlying...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 62
Published: 25 November 2004
10.1159/000082462
EISBN: 978-3-318-01119-7
... chromosome regions by comparative genomic hybridization.Results: The overall ratio of gains and losses was higher in metastases (M) than in primary(P) tumors (4/1 vs. 2.5/1). Gains of 3q (78.1% P vs. 87.5% M) and 11q (78.1% P vs. 62.5%M), and deletions of 3p (43.8% P vs. 34.4% M) and 9p (31.3% P vs. 15.6% M...
Book Chapter
Series: Monographs in Oral Science
Volume: 30
Published: 08 March 2022
10.1159/000520788
EISBN: 978-3-318-06913-6
... Abstract The field of genomics was launched when the mapping of DNA in humans and other species was accomplished. A new area began for the integrated study of all the genes in an organism, and in the case of humans, the understanding of the results of related biomedical interventions that can...
Book
Book Chapter
Series: Medicine and Sport Science
Volume: 61
Published: 16 June 2016
10.1159/000445241
EISBN: 978-3-318-03011-2
... number of genetic variants in small, often heterogeneous cohorts has not generated results of practical significance. Hypothesis-free genome-wide approaches will in the future provide more comprehensive coverage and in-depth understanding of the biology underlying sports-related traits and related...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 84
Published: 18 January 2016
10.1159/000436950
EISBN: 978-3-318-05599-3
... Abstract While scientific methods have dominated research approaches in biology over the past decades, it is increasingly recognized that the complexity of biological systems must be addressed by a different approach, namely unbiased research involving the collection of large amounts of genome...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382066
EISBN: 978-3-318-05497-2
... genes such as BARD1 , CHEK2 and PTPN11 have been found to be involved in the pathogenesis of neuroblastoma by genome-wide association studies and next-generation sequencing technologies. Integrative analysis of genome and transcriptome data from neuroblastoma samples has also identified genes...
Book Chapter
Series: Karger eBooks Non-Series Collection
Published: 02 June 2015
10.1159/000375209
EISBN: 978-3-318-03004-4
... for approximately one tenth of all cardiac malformations. In addition, genomic disorders often resulting from instability of the regional genomic architecture, constitute a major fraction of CVM. These events are usually submicroscopic, and are observed as genomic deletions and/or duplications. The widespread use...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 40
Published: 09 October 2014
10.1159/000364930
EISBN: 978-3-318-02730-3
... is rare or absent. When recombination is rare, selection is expected to act chiefly on rare large-effect mutations, which purge genetic variation due to genome-wide hitchhiking. In such species, the systems biology of aging can focus on the effects of large-effect mutants, transgenics, and combinations...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 101
Published: 03 May 2010
10.1159/000314511
EISBN: 978-3-8055-9428-8
... during their own fetal life later showed increased reproductive success [ 13 ]. Importantly it has been shown the effects can be passed on to the third generation, arguing strongly for non-genomic transmission of information or memory [ 14 ]. Thus, birth size provides some useful information, but has...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 101
Published: 03 May 2010
10.1159/000314516
EISBN: 978-3-8055-9428-8
... During the past 10 years, the use of transcriptomics, or genome-wide measurements of gene expression, has become more routine in toxicology studies. In the area of drug discovery and development, expression profiling is recognized to add value to preclinical studies for certain types...
Book Chapter
Series: Genome Dynamics
Volume: 6
Published: 27 August 2009
10.1159/000235768
EISBN: 978-3-8055-9193-5
... Abstract The genus Burkholderia consists of a number of very diverse species, both in terms of lifestyle (which varies from category B pathogens to apathogenic soil bacteria and plant colonizers) and their genetic contents. We have used 56 publicly available genomes to explore the genomic...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317279
EISBN: 978-3-8055-9596-4
... Abstract In genome-wide association studies using single nucleotide polymorphisms (SNPs), typically thousands of SNPs are genotyped, whereas the number of phenotypes for which there is genomic information may be smaller. A two-step SNP (feature) selection method was developed, which consisted...
Book Chapter
Series: Genome Dynamics
Volume: 4
Published: 14 April 2008
10.1159/000126003
EISBN: 978-3-8055-8492-0
... Abstract Whole genome duplications (WGD) have been a frequent occurrence during the evolutionof angiosperms, providing all gene families the opportunity to grow and diversify. Mostof this potential growth has not been realized, since each WGD has been followed by massivegene losses...
Book Chapter
Series: Endocrine Development
Volume: 11
Published: 20 November 2007
10.1159/000111051
EISBN: 978-3-8055-8348-0
... Abstract Genomic research has made great progress to understanding functional roles in noncodingDNA sequences. In particular, approaches to identify regulatory elements withenhancer/silencer function based on the synergism between computational and experimentaltechniques are discussed...
Book Chapter
Series: Endocrine Development
Volume: 12
Published: 24 September 2007
10.1159/000109637
EISBN: 978-3-8055-8386-2
... Abstract Genomic imprinting results in the deliberate silencing of alleles, dictated by their parental origin, butreversible on passage through the germ line. In this chapter, we shall consider the functional propertiesof imprinted genes, why these genes might have been singled out...
Book Chapter
Series: Forum of Nutrition
Volume: 60
Published: 17 August 2007
10.1159/000107077
EISBN: 978-3-318-01499-0
... Abstract Cancer results from a disordered and unstable genome - the degree of abnormality progressesas the process of oncogenesis proceeds. Such genomic instability appears to be subjectto control by environmental factors as evidenced by the number of cancers that are eithercaused by specific...
Book Chapter
Series: Issues in Infectious Diseases
Volume: 5
Published: 25 June 2007
10.1159/000104245
EISBN: 978-3-318-01399-3
... parasitism. The recent partial and complete sequencing of a number ofWolbachia genomes is providing a wealth of comparative data that can be used to betterunderstand the biology of these organisms, from providing putative genes and mechanismsinvolved in host interaction through to new polymorphic markers...
Book Chapter
Series: Pain and Headache
Volume: 15
Published: 15 May 2007
10.1159/000101977
EISBN: 978-3-318-01455-6
... to a particular patient’s molecularor genomic fingerprint. New thinking endorses that (1) genes constitute risk factors bythemselves, (2) they may amplify an existing polygenic risk or (3) they may exacerbate theeffect of an environmental risk factor and/or risk-conferring behavior. At first impression, itmay...
Book Chapter
Series: Genome Dynamics
Volume: 2
Published: 24 July 2006
10.1159/000095097
EISBN: 978-3-318-01376-4
... Abstract Though researchers are uncovering valuable information about the pig genome atunprecedented speed, the porcine genome community is barely scratching the surface as tounderstanding interactions of the biological code. The pig genetic linkage map has nearly5,000 loci comprised of genes...