... and prevent systemic infection by blocking potential pathogens. Early exposure to SIgA in breast milk resulted in a pattern of intestinal epithelial cell expression that differed from mice that were not exposed to passive SIgA. This included intestinal inflammation-related genes that are associated...

... Abstract Despite many recent advances in the management of gliomas, such as aggressive surgical resection, chemoradiotherapy, antiangiogenic therapy, and molecular targeted therapy, the survival of patients with high-grade neoplasms remains dismal. Gene therapy and oncolytic virotherapy have...

... Abstract Gene therapy is a clinical tool that may eventually provide therapeutic benefit to patients suffering from movement disorders through a few potential mechanisms: direct correction of the pathogenic mechanism, neuroprotection, neurorestoration or symptom control. The therapeutic...

... Abstract In the euchromatic part of the long arm of the human Y chromosome (Yq11) at least 13 Y genes encoding proteins and expressed in male germ cells were found in 3 distinct genomic Y regions frequently deleted in infertile men with idiopathic azoospermia, i.e., for unknown reasons...

... Abstract The advent of gene transfer technologies in clinical studies aroused concerns that these technologies will be misused for performance-enhancing purposes in sports. However, during the last 2 decades, the field of gene therapy has taken a long and winding road with just a few gene...

... expressed on activated T cells as well as regulatory T cells, and is crucial for the survival and function of T cells, Th2 differentiation and allergic response. However, the effect of blockage of the ICOS/ICOSL pathway in allergic rhinitis remains unclear. Adenovirus is a common viral vector used in gene...

... Abstract Genetic forms of sensorineural deafness account for almost half of all patients with congenital hearing loss (HL). Increasing knowledge of the underlying molecular and genetic mechanisms that lead to HL raises the possibility for novel therapeutics, such as those based on gene transfer...

... Abstract High-throughput metabolomic, proteomic, and genomic technologies have delivered 21st-century data showing that humans cannot be randomized into groups: individuals are genetically and biochemically distinct. Gene-environment interactions caused by unique dietary and lifestyle factors...

... Abstract Gene therapy for rare inherited neurologic diseases has entered the clinics. One strategy relies upon the replacement of brain microglia using hematopoietic stem cell gene therapy with lentiviral vectors. Therapeutic success using this approach has been obtained in X-linked...

... Abstract Ocular gene therapy involves the introduction of an exogenous gene product to a host's cellular and genetic machinery for endogenous production of a desired gene product. The eye represents an ideal target organ due to its easy visibility and accessibility, and several trials have...

... Abstract Increasing evidence supports the involvement of both heritable and environmental risk factors in suicidal behaviour (SB). Gene-environment interaction (G × E) studies may be useful for elucidating the role of biological mechanisms in the risk for mental disorders. In the present...

... Abstract Using global gene expression analysis, the effects of biomaterials and nanomaterials can be analyzed at the genetic level. Even though information obtained from global gene expression analysis can be useful for the evaluation and design of biomaterials and nanomaterials, its use...

... Abstract This chapter describes single-gene syndromes that include congenital heart malformations as part of their phenotype. With the exception of Goldenhar syndrome (craniofacial microsomia syndrome), at least one known causative gene has been identified in the described syndromes. Even...