... Abstract As the most malignant brain tumor, glioblastoma (GBM) leads to death in less than 15 months after diagnosis, despite maximal therapeutic treatment using resection and radiochemotherapy. Therefore, new treatment options are urgently needed. Complementary and alternative medicine has...

... Abstract Management options for residual or recurrent glioblastoma multiforme (GBM) are limited despite advances in surgical, chemotherapeutic, and radiotherapeutic techniques. Stereotactic radiosurgery (SRS) is often beneficial in such cases providing improved survival of patients, but still...

... Organization grade 3–4 tumors (anaplastic glioma and glioblastoma multiforme; GBM). The management of high-grade glioma (HGG) remains a challenge. During the past decade, modest improvements in survival have been achieved using multimodality options that include surgery when feasible, radiation therapy...

... called rapid progressive glomerulonephritis (RPGN) because if untreated, patients develop renal failure within days or weeks of diagnosis [ 1 ]. RPGN is usually caused by one of three mechanisms: anti-glomerular basement membrane (anti-GBM) antibody disease with or without pulmonary hemorrhage, severe...

... suggests that such treatment produces favorable results in patients with recurrent glioblastoma multiforme (GBM), but is not associated with any benefits in newly diagnosed GBM and recurrent WHO grade III gliomas. Initial experience using BEV for management of central nervous system radiation necrosis...

... the mechanisms of tumorigenesis and treatment resistance is necessary for the development of MTT. Multiple alterations in the expression levels of genes or proteins have been identified in gliomas. For instance, The Cancer Genome Atlas (TCGA) research network classified glioblastoma multiforme (GBM...

... (Alport syndrome, HANAC syndrome), a laminin disorder (Pierson syndrome), nail-patella syndrome and HERNS syndrome. These models can be exploited in studies of the pathogenesis and treatment of such disorders. The glomerular basement membrane (GBM) is a critical component of the glomerular...

... anticancer agent and was the first chemotherapeutic drug to unequivocally demonstrate activity against glioblastoma multiforme (GBM) in combination with FRT [ 1 ]. It causes methylation of the O 6 and N 7 residues of guanine and triggers MMR complex, which repairs the native strand instead...

... gliomas are the most common primary brain tumors and are associated with very low survival rates. Of these neoplasms, glioblastoma multiforme (GBM), corresponding to World Health Organization (WHO) histopathological grade IV, is the most common and has a dismal prognosis with a median survival of only 14...

... Abstract Diabetic nephropathy (DN) develops in a subset of diabetic patients, on average about 15 years after onset of metabolic abnormalities. The earliest lesions consist of thickened glomerular basement membranes (GBM), mild mesangial expansion, and arteriolar accumulation of hyaline...

... tumors such as meningiomas and schwannomas, but also tumors with a dismal prognosis, high-grade glioma, of which WHO grade IV astrocytoma or glioblastoma multiforme (GBM) is the most lethal [ 1 ]. GBM can present de novo in patients, without evidence of evolution from a lower-grade tumor (primary GBM...

... and reported median survival in cases of newly diagnosed and recurrent glioblastoma multiforme (GBM) of 16.1 and 10.3 months, respectively. In some series, increase in the long-term survival rates was also observed. Few controlled trials demonstrated statistically significant impact of PDT on prolongation...

... immunogenic cell death, which may potentiate an immune response against treated tumors. Notably, in patients with recurrent glioblastoma multiforme (GBM) a prospective clinical trial demonstrated comparable overall survival and progression-free survival after TTFields therapy and best physician's choice...

... the mesangium and along the glomerular basement membrane (GBM) in the subendothelial area or within the GBM. The key role of complement alternative pathway (AP) in these disorders has been recently shown with the identification of acquired or genetic abnormalities. Low serum C3 level but normal C4 is a common...

... Abstract Rapidly progressive glomerulonephritis (RPGN) is a life-threatening disease with a poor prognosis. In this review, the pathogenesis of RPGN owing to antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis and anti-GBM diseases is discussed. By the model...