... gastrocystoplasty with fundectomy in rats. Gastric ECL cell hyperplasia and ECLoma develop after one year in rats treated with omeprazole or 2–4 months in Mastomys treated with loxtidine. The ECL cells were fully under control of gastrin during pregnancy and lactation, and during the estrous cycle. Estrogen-like...

... and glucose-dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides. Acta Physiol (Oxf) 2011;201:405-411. 17. Persson P, Håkanson R, Axelson J, Sundler F: Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach. Proc Natl Acad Sci U S A 1989;86...

... mucosa [ 2 ] contained another messenger (“gastric secretin” - abbreviated gastrin). Hence, the first discovery of blood-borne “chemical messengers” was of gastrointestinal origin, and the very concept of endocrinology can be said to be born in the gut. Subsequently, Starling introduced the word hormone...

...References References 1. Koh TJ, Chen D: Gastrin as a growth factor in the gastrointestinal tract. Regul Pept 2000;93:37-44 2. Watson SA, Grabowska AM, El-Zaatari M, Takhar A: Gastrin - active participant or bystander in gastric carcinogenesis?. Nature reviews Cancer 2006;6:936-946 3...

... of endocrine syndromes are classical carcinoid syndrome caused by serotonin (measured in the urine as its metabolite 5-HIAA), insulinoma syndrome caused by insulin or proinsulin, Zollinger-Ellison syndrome resulting from gastrin secretion, glucagonoma syndrome caused by glucagon, WDHA syndrome caused...