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frailty

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Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 82
Published: 02 November 2015
10.1159/000382011
EISBN: 978-3-318-05499-6
... of disability) and the ‘robust' (those without frailty or disability). However, despite evidence linking frailty with a poor outcome, frailty is not implemented clinically in most countries. Since many people are not identified as frail, their treatment is frequently inappropriate in health care settings...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 41
Published: 22 July 2015
10.1159/000381164
EISBN: 978-3-318-05457-6
... Abstract In both demographic and clinical studies, frailty is understood as a multidimensional state of increased vulnerability compared with the status of others of the same age. Of the many theoretical definitions of frailty, two are commonly employed: the physical frailty/phenotypic approach...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 41
Published: 22 July 2015
10.1159/000381166
EISBN: 978-3-318-05457-6
... Abstract The previous chapter focused on the conceptualization and operationalization of the deficit accumulation and phenotypic approaches to the description of frailty. The purpose of this chapter is to summarize some studies that compared these most commonly used frailty definitions. We also...
Book Chapter
Series: Contributions to Nephrology
Volume: 196
Published: 09 August 2018
10.1159/000485707
EISBN: 978-3-318-06298-4
... in the United States and Europe. Frailty is generally considered as an age-related fragile state, and a condition in which the individual is in a vulnerable state at increased risk of adverse health outcomes and/or dying when exposed to a stressor. This review focuses on the underscoring the importance...
Book Chapter
Series: Contributions to Nephrology
Volume: 195
Published: 22 May 2018
10.1159/000486940
EISBN: 978-3-318-06350-9
... Abstract Frailty is a clinical state in which there is an increase in the individual's vulnerability to developing increased dependency and/or mortality when exposed to a stressor. Since the mean age of dialysis patients is increasing worldwide, frailty has recently come to be considered one...
Book Chapter
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382052
EISBN: 978-3-318-05478-1
... Abstract Frailty is an important construct in aging which allows for the identification of the most vulnerable subset of older adults. At least two conceptual models of frailty have been developed that have in turn facilitated the development of multiple frailty screening tools. This has...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382054
EISBN: 978-3-318-05478-1
... Abstract Population aging simultaneously highlights the remarkable advances in science, medicine, and public policy, and the formidable challenges facing society. Indeed, aging is the primary risk factor for many of the most common chronic diseases and frailty, which result in profound social...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382055
EISBN: 978-3-318-05478-1
... Abstract Late-life aging in humans is often associated with severe frailty. This suggests catastrophic events reaching an undeniable biological threshold in cellular stability and a rapidly diminished homeostasis. The driving force of the syndrome is likely ‘genetic instability' or ‘genomic...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382057
EISBN: 978-3-318-05478-1
... Abstract Older people are at risk of developing frailty with advancing age. The prevalence of frailty increases from 2.5-3% in adults aged 65 years to 30-35% in those older than 85 years. These results suggest that an association exists between longevity and frailty. However, at the same time...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000430966
EISBN: 978-3-318-05478-1
... Abstract Frailty has been defined as a geriatric syndrome that is characterized by a reduction in the physiological reserve required for an individual to respond to endogenous and exogenous stressors. Using a discrete definition of frailty that includes sedentariness, involuntary weight loss...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382060
EISBN: 978-3-318-05478-1
... Abstract There is little written in the geriatric literature about the concept of psychological frailty which encompasses cognitive, mood, and motivational components. The concept is intended to consider brain changes that are beyond normal aging, but not necessarily inclusive of disease...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382061
EISBN: 978-3-318-05478-1
... Abstract Frailty is recognized as a clinical geriatric syndrome used to describe the weakest or most vulnerable older adults. Although the term frailty is commonly used in clinical practice, and the theoretical phenomenon is well accepted, it remains an evolving concept that lacks a universally...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382063
EISBN: 978-3-318-05478-1
... Abstract Aging is characterized by the catabolism of muscles leading to sarcopenia and frailty. These are two geriatric syndromes with partly overlapping phenotypes. Primary sarcopenia, i.e. loss of muscle mass and function related to aging alone, usually precedes frailty. Thus, robustness...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382065
EISBN: 978-3-318-05478-1
... Abstract Longitudinal studies demonstrate that regular physical exercise extends longevity and reduces the risk of physical disability. Decline in physical activity with aging is associated with a decrease in exercise capacity that predisposes to frailty. The frailty syndrome includes a lowered...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382091
EISBN: 978-3-318-05478-1
... Abstract Frailty is a geriatric syndrome characterized by reduced homeostatic reserves, exposing the organism to extreme vulnerability to endogenous and exogenous stressors. Since disability is considered as an almost irreversible condition at advanced age, frailty has been indicated...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382092
EISBN: 978-3-318-05478-1
... persons at risk of negative outcomes. Major medical specialties (e.g., oncology, cardiology, neurology…) have already moved to an early stage of the diseases to be more effective. Geriatric medicine must do the same moving to frailty an early stage of disability were intervention are more likely...
Book
Book Cover Image
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/isbn.978-3-318-05478-1
EISBN: 978-3-318-05478-1
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 41
Published: 22 July 2015
10.1159/000381127
EISBN: 978-3-318-05457-6
... the best approach to study how deficits scale remains a key goal for understanding aging. In consequence, approaching the problem of frailty as one of the scaling of subcellular deficits has implications for understanding aging. Considering the cumulative effects of many small deficits appears to allow...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 41
Published: 22 July 2015
10.1159/000381131
EISBN: 978-3-318-05457-6
... Abstract Animal models have contributed greatly to our understanding of the biology of aging and have been used to test new potential interventions to enhance survival. However, whether these interventions can modify frailty in animals is not yet clear, in part because until recently, frailty...