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Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 81
Published: 30 May 2002
10.1159/000058867
EISBN: 978-3-318-00830-2
Book Chapter
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396301
EISBN: 978-3-318-03447-9
... Abstract The structure of single filaments of horny cells of normal and psoriatic epidermis was studied in the electron microscope in situ and in filaments reconstituted from urea extracts by dialysis, against low ionic strength buffer. It was found that both in situ and reconstituted filaments...
Book Chapter
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396304
EISBN: 978-3-318-03447-9
... Abstract Keratin extracted from keratinized cells of newborn rats polymerizes into filaments in vitro and this polymerization has been shown to be greatly stimulated by addition of divalent cations. In this study we investigated the optimum conditions for filament formation by use of CaCl2...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396298
EISBN: 978-3-318-03447-9
... Abstract The stratum corneum basic protein (SCBP) aggregates specifically with keratin filaments, forming macrofibrils in which the filaments are highly aligned. The appearance of the macrofibrils formed in vitro is similar to the keratin pattern in the intact stratum corneum, suggesting...
Book Chapter
Published: 15 February 1995
10.1159/000424645
EISBN: 978-3-318-04779-0
... Abstract The cytoskeletal organization of the guinea pig vestibular sensory cells was investigated employing the saponin perfusion method using scanning electron microscopy as well as immunohistochemical technique. The intermediate filaments were demonstrated in the sensory cells. They were...
Book Chapter
Published: 23 February 2007
10.1159/000100403
EISBN: 978-3-318-01436-5
... by electron microscope.Myofibroblasts were found around acini at the initial stage of periacinar fibrosis, and wereaccompanied by numerous fine filaments 8-15 nm in diameter. In the acinar cells at the initialstage of periacinar fibrosis, various changes in zymogen granules (ZG), lysosomes andlipid droplets...
Book Chapter
Series: Contributions to Nephrology
Volume: 195
Published: 22 May 2018
10.1159/000486943
EISBN: 978-3-318-06350-9
... and proteinuria. Excessive or persistent injury leads to disruption of focal adhesions and podocyte detachments. Substantial decrease in podocyte density results in glomerulosclerosis and renal dysfunction. b Schematic representation of the interdigitating podocyte foot processes. Actin filaments construct...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396303
EISBN: 978-3-318-03447-9
... acids, higher contents of α-helix, and only limited facility for polymerization in vitro into native-type epidermal keratin filaments. As the α-helix-enriched fragments, which represent up to two-thirds of the polypeptide chains, isolated after limited tryptic digestion ofthe keratin filaments of normal...
Book
Book Cover Image
Published: 15 March 1995
10.1159/isbn.978-3-318-05125-4
EISBN: 978-3-318-05125-4
Book
Book Cover Image
Published: 12 February 1981
10.1159/isbn.978-3-318-04633-5
EISBN: 978-3-318-04633-5
Book
Book Cover Image
Published: 15 February 1995
10.1159/isbn.978-3-318-04779-0
EISBN: 978-3-318-04779-0
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
10.1159/000441539
EISBN: 978-3-318-05586-3
... consists mainly of keratin filaments aggregated by filaggrin (FLG) protein. Next, together with several other proteins, FLG is cross-linked into a mechanically robust cornified cell envelope providing a scaffold for the extracellular lipid matrix. In addition to its role for the SC structural...
Book
Book Cover Image
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/isbn.978-3-318-03447-9
EISBN: 978-3-318-03447-9
Book Chapter
Series: Current Problems in Dermatology
Volume: 41
Published: 09 May 2011
10.1159/000323291
EISBN: 978-3-8055-9687-9
... to keratin filament aggregation. Its breakdown products form natural moisturizing factor, which plays a central role in hydration of the SC. Sequence analysis and epidemiological studies indicate that loss-of-function mutations in the filaggrin gene known to cause the autosomal dominant scaly skin disorder...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 26
Published: 20 April 2009
10.1159/000212374
EISBN: 978-3-8055-9142-3
... flexion, knee extension and ankle dorsiflexion. Vacuolated fibers, amyloid deposition, and filaments on electron microscopy are pathologic hallmarks of IBM. IBM is refractory to corticosteroids and intravenous gamma globulins. This clinical observation and the pathologic features support the hypothesis...