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filaggrin

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Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
10.1159/000441539
EISBN: 978-3-318-05586-3
... consists mainly of keratin filaments aggregated by filaggrin (FLG) protein. Next, together with several other proteins, FLG is cross-linked into a mechanically robust cornified cell envelope providing a scaffold for the extracellular lipid matrix. In addition to its role for the SC structural...
Book Chapter
Series: Current Problems in Dermatology
Volume: 41
Published: 09 May 2011
10.1159/000323291
EISBN: 978-3-8055-9687-9
... Abstract Atopic dermatitis (AD) is a chronic relapsing eczematous skin disorder that is frequently associated with elevated serum IgE levels and a personal or family history of AD, allergic rhinitis and/or asthma. Filaggrin is a major constituent of the stratum corneum (SC) and contributes...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
EISBN: 978-3-318-05586-3
...: Transepidermal water loss and skin site: a hypothesis. Int J Pharm 2009;373:1-3. 3. McAleer MA, Irvine AD: The multifunctional role of filaggrin in allergic skin disease. J Allergy Clin Immunol 2013;131:280-291. 4. Thyssen JP, Kezic S: Causes of epidermal filaggrin reduction and their role...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 96
Published: 16 March 2012
10.1159/000331889
EISBN: 978-3-8055-9895-8
... regulate filaggrin, a very important component of the skin barrier, as well as proteins involved in the processing and maturation of filaggrin. Therefore, inflammation itself may be able to induce a functional skin barrier dysfunction and thereby aggravate the eczematous reaction in AD. Atopic...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
10.1159/000441540
EISBN: 978-3-318-05586-3
... of the lipids are discussed. In addition, this review addresses how these changes in lipid composition induce changes in lipid organization and subsequently correlate with an impaired skin barrier function in both lesional and nonlesional skin of these patients. Furthermore, the effect of filaggrin...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 96
Published: 16 March 2012
10.1159/000331807
EISBN: 978-3-8055-9895-8
... Abstract In both clinical experience and molecular genetic studies, atopic diseases (asthma, rhinoconjunctivitis and eczema) have been found to be strongly genetically influenced. The epidermal protein filaggrin seems to play a crucial role and is encoded within the so-called epidermal...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 96
Published: 16 March 2012
EISBN: 978-3-8055-9895-8
... 7. Palmer CN, Irvine AD, et al: Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006;38:441-446 8. Sandilands A, Terron-Kwiatkowski A, et al: Comprehensive analysis of the gene encoding filaggrin...
Book Chapter
Series: Current Problems in Dermatology
Volume: 41
Published: 09 May 2011
EISBN: 978-3-8055-9687-9
... O’Regan GM Watson RM Cecil JE Bale SJ Compton JG Di Giovanna JJ Fleckman P Lewis-Jones S Arseculeratne G Sergeant A Munro CS El Houate B McElreavey K Halkjaer LB Bisgaard H Mukhopadhyay S McLean WH: Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 96
Published: 16 March 2012
10.1159/000331871
EISBN: 978-3-8055-9895-8
.... We suggest that IL-25 could be a major target in AD. IL-25 is produced by cells within the dermis of AD patients, and we suggest these to be dendritic cells (DCs). Furthermore, we show that IL-25 can inhibit filaggrin synthesis in keratinocytes. These results point towards a central role of IL-25...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
10.1159/000489523
EISBN: 978-3-318-06385-1
... is filaggrin [ 16 ]. Other proposed sources of AA include Hornerin and Filaggrin-2, all of which are structurally related proteins expressed during the late stages of keratinocyte terminal differentiation [ 17 , 18 ]. Filaggrin is the best characterised and exhibits multiple functions making it critically...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
10.1159/000441589
EISBN: 978-3-318-05586-3
... defense from environmental assaults and incorporates physical, chemical and biological protection. Skin barrier disturbance plays a crucial role in various skin diseases such as atopic dermatitis (AD), ichthyosis, ICD and ACD. Genetic factors, such as filaggrin gene (FLG) mutations, and external factors...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
EISBN: 978-3-318-05586-3
...: Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 2014;134:792-799. 4. Thyssen JP, Godoy-Gijon E, Elias PM: Ichthyosis vulgaris: the filaggrin mutation disease. Br J Dermatol 2013;168:1155-1166. 5. Smith FJ, Irvine AD, Terron...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 96
Published: 16 March 2012
EISBN: 978-3-8055-9895-8
...-Kwiatkowski A, Zhao Y, Liao H, Lee SP, et al: Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006;38:441-446 4. Sandilands A, Sutherland C, Irvine AD, McLean WH: Filaggrin in the frontline: role in skin barrier...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
EISBN: 978-3-318-06385-1
..., Baurecht H, Cifuentes L, Hogh JK, et al: Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 2010;65:911-918. 9. Winge MC, Hoppe T, Berne B, Vahlquist A, Nordenskjold M, Bradley M, et al: Filaggrin genotype determines functional and molecular...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
EISBN: 978-3-318-05586-3
... measurement. AIChE J 1975;21:985-996. 3. Simon M, Haftek M, Sebbag M, Montezin M, Girbal-Neuhauser E, Schmitt D, Serre G: Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis. Biochem J 1996;137:173-177. 4. Armengot-Carbo M, Hernandez-Martin A, Torrelo...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
10.1159/000441588
EISBN: 978-3-318-05586-3
... acquires a rough dry appearance. To prevent this happening, the epidermis contains a number of water-retaining substances, the most important of which is natural moisturizing factor, a compound composed of a mixture of amino acids, amino acid derivatives and salts generated by filaggrin hydrolysis...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
EISBN: 978-3-318-05586-3
.... 5. Katagiri C, Sato J, Nomura J, Denda M: Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice. J Dermatol Sci 2003;31:29-35. 6. Elias PM, Ansel JC, Woods LD...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
10.1159/000441548
EISBN: 978-3-318-05586-3
... are synthesized and secreted into the intercellular matrix. In the granular layer, important proteins, including filaggrin, are produced. At last, keratinocytes reach the SC where they collapse and become anucleated corneocytes, which are shed off after a certain time [ 2 ]. Filaggrin is important...
Book Chapter
Series: Current Problems in Dermatology
Volume: 39
Published: 15 September 2010
EISBN: 978-3-8055-9395-3
.... Hohl D: Cornified cell envelope. Dermatologica 1990;180:201-211 58. Greenberg CS, Birckbichler PJ, Rice RH: Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues. Faseb J 1991;5:3071-3077 59. Steinert PM, Marekov LN: The proteins elafin, filaggrin, keratin intermediate...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
10.1159/000489521
EISBN: 978-3-318-06385-1
... processed by the addition and crosslinking of further proteins of which most are expressed in a calcium-dependent manner: loricrin, filaggrin, small proline rich repeat proteins (a family of 15 members) and the late CE proteins (in total 18 members). Besides lipids, tight junctions (e.g., corneodesmosomes...