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fibroblast

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Book Chapter
Series: Contributions to Nephrology
Volume: 196
Published: 09 August 2018
10.1159/000485696
EISBN: 978-3-318-06298-4
... Abstract Fibroblast growth factor 23 (FGF23) is a regulator of phosphate and vitamin D homeostasis that carries out primary bone- and mineral-related physiological functions to increase renal phosphate excretion and reduce 1α-hydroxylation of 25-hydroxyvitamin D. In a negative endocrine...
Book Chapter
Series: Contributions to Nephrology
Volume: 190
Published: 29 May 2017
10.1159/000468952
EISBN: 978-3-318-06061-4
... insights into fibroblast growth factor (FGF) 23 have led to marked advancement in interpreting data on CVD and CKD progression ascribing to FGF23 a pivotal role in these pathologies independent of its co-receptor klotho and well beyond mineral metabolism. This review article will discuss the current...
Book Chapter
Series: Endocrine Development
Volume: 21
Published: 23 August 2011
10.1159/000328129
EISBN: 978-3-8055-9793-7
..., while FGF- 23 also accelerates cotransporter degradation in the lysosome and reduces NaPi-IIa and NaPi-IIc expression [ 5 ]. Fibroblast Growth Factor- 23 FGF- 23 is a 30-kDa protein that is proteolytically processed to generate smaller NH2-terminal (18 kDa) and COOH-terminal(12 kDa) fragments...
Book Chapter
Series: Frontiers of Oral Biology
Volume: 12
Published: 04 February 2008
10.1159/000115037
EISBN: 978-3-8055-8152-3
... Abstract Apert, Pfeiffer and Crouzon syndromes are congenital craniosynostosis syndromescaused by mutations that perturb the level of fibroblast growth factor receptor (FGFR) signaling.The cellular and molecular impact of these mutations have been studied in vitro andin animal models in vivo...
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Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 23
Published: 09 December 1987
10.1159/000415173
EISBN: 978-3-318-03743-2
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