... Abstract Background: Serum ferritin is one of the most important and widely used markers of iron metabolism, and is a recommended standard index of iron dynamics in guidelines for renal anemia in many countries. However, serum ferritin measurement has several disadvantages. For example...

... Abstract The diagnostic value of serum ferritin measurements in discriminating iron-deficiency anemia from thalassemia trait has been studied. In contrast to serum iron, percent transferrin saturation and total iron-binding capacity, where a high degree of overlap existed between the two groups...

... Abstract The effect of maturation on ferritin synthesis in erythroid precursor cells was studied in vitro in a population of rabbit bone marrow cells synchronized by actinomycin D. Undifferentiated hemopoietic stem cells were compared with orthochromatic normoblasts and reticulocytes, following...

... and the labile iron pool) is present in even the smallest quantities, it produces extremely toxic hydroxyl radicals through the Fenton's reaction. In the body, iron is bound to transferrin in the blood and is stored as ferritin within cells, maintaining the iron levels while suppressing free iron as much...

...References References 1. Laufberger MV: Sur la cristallisation de la ferritine. Bull Soc Chim Biol 1937;19:1575. 2. Addison GM, Beamish MR, Hales CN, Hodgkins M, Jacob A: An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron...

... synthesizing hemoglobin but also by other tissues for growth or replacement of iron-containing proteins. Ferritin Surplus iron is non-toxically stored in an intracellular protein, ferritin, which is found in cellular cytoplasm of most tissues. A small amount of ferritin is secreted into the circulation...

... that a high risk of death and/or adverse events was associated with persistently high ferritin levels, large fluctuations in ferritin levels and high doses of intravenous iron [ 3 ]. Nevertheless, it has not been determined whether a reduction in ESA dose, along with a prolonged therapy with high doses...

... and nonelderly MHD patients, the hemoglobin (Hb) level was significantly lower and the serum ferritin level was significantly higher in elderly patients than in nonelderly patients (Fig.  1 ). Thus, when managing anemia in elderly CKD patients, the characteristic pathologies of these patients should...

.... Brookhart MA, Freburger JK, Ellis AR, et al: Infection risk with bolus versus maintenance iron supplementation in hemodialysis patients. J Am Soc Nephrol 2013;24:1151-1158. 5. Nakanishi T, Kuragano T, Nanami M, Otaki Y, Nonoguchi H, Hasuike Y, et al: Importance of ferritin for optimizing anemia therapy...

... metabolism or absorption is well regulated? Dr. Domellöf: There are huge changes in iron status and metabolism during the first year of life. It seems that most infants would have adequate iron absorption irrespective of their iron status. Dr. Gupta: In LBW infants, ferritin levels on umbilical...

... in HFE and progressing to an elevated transferrin saturation, increased serum ferritin and then tissue deposition of iron with the potential for progression to hepatic fibrosis and cirrhosis and other organ damage (fig. 2 ). The majority (70-80%) of male C282Y-homozygous subjects will have increased...

.... 2. Kuragano T, Matsumura O, Matsuda A, Hara T, Kiyomoto H, Murata T, Kitamura K, Fujimoto S, Hase H, Joki N, Fukatsu A, Inoue T, Itakura I, Nakanishi T: Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients. Kidney Int...