... Abstract Fixed drug eruption (FDE) is generally regarded as representing the mild end of drug-induced dermatitis, but the clinical importance of recognizing this disease as an abortive, localized variant of toxic epidermal necrolysis has received increasing attention in recent years. FDE often...

... eosinophils. d Emperipolesis. DRESS. Drug Reactions with Predominant Cytotoxic Epidermal Changes Erythema Multiforme/Fixed Drug Eruption Targetoid maculae are the typical lesions in EM. Fixed drug eruption (FDE) clinically presents with violaceous patches and plaques, leaving...

... ]. Fixed Drug Eruption Fixed drug eruption (FDE) represents a late type hypersensitivity reaction against a single drug or a combination of different, structurally related drugs [ 13 ]. The typical clinical features are sharply defined livid plaques with a site preference on the face/lips, hands...

...) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation. Clin Endocrinol (Oxf) 2007;66:466-474 19. de Paula FJ, Góis-Júnior MB, Aguiar-Oliveira MH, Pereira Fde A, Oliveira CR, Pereira RM, Farias CT, Vicente TA, Salvatori R: Consequences of lifetime...

.... Do LM, Tran TK, Eriksson B, Petzold M, Nguyen CT, Ascher H. Preschool overweight and obesity in urban and rural Vietnam: differences in prevalence and associated factors. Glob Health Action. 2015;8:28615. 7. Schuch I, Castro TG, Vasconcelos Fde A, Dutra CL, Goldani MZ. Excess weight...

...-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin Endocrinol Metab 2002;87:506-512. 32. Alessandri SB, Pereira Fde A, Villela RA, Antonini SR, Elias PC, Martinelli CE Jr, Castro M, Moreira AC...

... be excluded. Non-Life-Threatening Cutaneous Adverse Drug Reactions Milder cutaneous ADR include MPE, fixed drug eruption (FDE), morbilliform eruption, urticaria, purpura, vasculitis and many other clinical manifestations. All of these reactions, except perhaps FDE, are not exclusively caused...

...: differences in prevalence and associated factors. Glob Health Action. 2015;8:28615. 7. Schuch I, Castro TG, Vasconcelos Fde A, Dutra CL, Goldani MZ. Excess weight in preschoolers: prevalence and associated factors. J Pediatr. 2013;89(2):179–88. 8. Gupta N, Shah P, Nayyar S, Misra A. Childhood obesity...

... 1997;42:377–383. 151. Buzalaf MA, de Moraes Italiani F, Kato MT, Martinhon CC, Magalhães AC: Effect of iron on inhibition of acid demineralisation of bovine dental enamel in vitro. Arch Oral Biol 2006;51:844–848. 152. Kato MT, Maria AG, Vaz LG, Italiani Fde M, Sales-Peres SH, Buzalaf MA: Effect...

... Endocrinol (Oxf) 2007;66:466-474 19. de Paula FJ, Góis-Júnior MB, Aguiar-Oliveira MH, Pereira Fde A, Oliveira CR, Pereira RM, Farias CT, Vicente TA, Salvatori R: Consequences of lifetime isolated growth hormone (GH) deficiency and effects of short-term GH treatment on bone in adults with a mutation...

... to protein or energy restricted diet during lactation. J Nutr Biochem 2004;15:123-127. 132. Faria Tda S, Brasil Fde B, Sampaio FJ, Ramos Cda F: Maternal malnutrition during lactation alters the folliculogenesis and gonadotropins and estrogen isoforms ovarian receptors in the offspring at puberty. J...

... and other chemicals Table 2. Reported HLA associations with drugs and other chemicals Adapted from Alfirevic and Pirmohamed [ 15 ]. HSS Hypersensitivity syndrome MPE maculopapular exanthema FDE fixed drug eruption Pre-treatment testing for AHS has been demonstrated...

... composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin Endocrinol Metab 2002;87:506-512. 32. Alessandri SB, Pereira Fde A, Villela RA, Antonini SR, Elias PC, Martinelli CE Jr, Castro M, Moreira AC, Paula FJ: Bone mineral density and body...

..., Martinhon CC, Magalhães AC: Effect of iron on inhibition of acid demineralisation of bovine dental enamel in vitro. Arch Oral Biol 2006;51:844–848. 152. Kato MT, Maria AG, Vaz LG, Italiani Fde M, Sales-Peres SH, Buzalaf MA: Effect of iron supplementation on the erosive potential of carbonated...

... S, Brasil Fde B, Sampaio FJ, Ramos Cda F: Maternal malnutrition during lactation alters the folliculogenesis and gonadotropins and estrogen isoforms ovarian receptors in the offspring at puberty. J Endocrinol 2008;198:625-634. 133. Smith JT, Spencer SJ: Preweaning over- and underfeeding alters...