... Abstract Chronic heart failure represents a leading cause of mortality and health care expenditure in developed countries. In the last 20 years, medical therapy of heart failure has dramatically changed thanks to the introduction of agents able to significantly reduce the neurohormonal...

... Abstract With the growing prevalence of acute liver failure or acute-on-chronic liver failure, on the one hand, and the limited supply of liver organs for transplantation, on the other hand, it is critical to the design, validate, and implement devices that can provide extracorporeal liver...

... Abstract Sepsis and multiple organ failure (MOF) are characterized by multiple hemodynamic changes and imbalanced immune response of the patient. Oxiris is a highly adsorptive membrane with the ability to remove cytokines and endotoxins, as well as to perform renal replacement therapy. Here we...

... Short bowel syndrome Intestinal failure Malabsorption Key Messages For optimal treatment of a child with intestinal failure, knowledge of the residual bowel length and location is crucial. Enteral feedings should be initiated as early as medically feasible to promote maximum...

... therapies varies depending on age and pubertal status at the exposure. The administration of chemo- and/or radiotherapy during childhood may damage both undifferentiated spermatogonia and proliferating Sertoli and Leydig cells, leading to azoospermia, failure of outgrowth of the seminiferous tubules...

...Key Messages Define parenteral nutrition-associated cholestasis and intestinal failure-associated liver disease. Review population characteristics, clinical risk factors, and diagnostic algorithms. Appraise the evidence for the prevention and management of disease with a focus...

... Abstract Heart failure (HF) represents the most common cause of hypervolemic hyponatremia in current clinical practice. The presence of hyponatremia has been independently associated with worse outcomes in this patient population. The pathogenesis of hyponatremia in HF involves complex...

... Abstract Proximal salt reabsorption in the hypertrophied tubules in the early phase of chronic renal failure (CRF) would be diminished according to the inhibited expression of proximal salt-transporting molecules, which may be facilitated by the inhibition of Na-K-ATPase expression. Results...

... Abstract Premature ovarian failure (POF), also termed primary ovarian insufficiency, is a common disorder in women of reproductive age. This discussion focuses predominately on single genes whose perturbations are associated with POF. Perturbations known to have deleterious effects were...

... and heart failure despite the wide availability of therapeutic agents and dietary and lifestyle modification. Device-based therapy by baroreflex activation via carotid sinus/nerve stimulation is currently undergoing investigation, and promising findings from clinical trials have been published. Baroreflex...