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Book Chapter
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000504996
EISBN: 978-3-318-06685-2
... and prevent systemic infection by blocking potential pathogens. Early exposure to SIgA in breast milk resulted in a pattern of intestinal epithelial cell expression that differed from mice that were not exposed to passive SIgA. This included intestinal inflammation-related genes that are associated...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441875
EISBN: 978-3-318-05651-8
... of their receptors is of considerable interest. We have examined the expression and localization of the receptors for these chemical mediators in human nasal mucosa. Here, we review our data on the expression and localization of these receptors in allergic rhinitis, and we discuss the roles of chemical mediators...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441884
EISBN: 978-3-318-05651-8
... the expression of NLRP3, ASC, interleukin (IL)-1β, IL-18 and caspase-1 in the specimens with and without human papilloma virus (HPV) infection using immunohistochemistry, and analyzed the correlations between the altered expression of these proteins and clinicopathological factors of oropharyngeal SCC. We found...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441888
EISBN: 978-3-318-05651-8
... Abstract Defensins are small antimicrobial peptides and effector components of innate immune responses. Recent studies have shed light on their beneficial functions for the prevention of infection and potential for development of new drugs. Here, we showed the expression profiles of human...
Book Chapter
Series: Frontiers of Oral Biology
Volume: 17
Published: 30 July 2015
10.1159/000381695
EISBN: 978-3-318-02461-6
... Abstract Using global gene expression analysis, the effects of biomaterials and nanomaterials can be analyzed at the genetic level. Even though information obtained from global gene expression analysis can be useful for the evaluation and design of biomaterials and nanomaterials, its use...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 4
Published: 30 April 2015
10.1159/000375427
EISBN: 978-3-318-05445-3
... cytokine-induced secretion of prostaglandin E2 (PGE2). This inhibitory action has been associated with reduced expression of COX-2, without modulating COX-1 expression. This mechanism is associated with VA-induced destabilization of COX-2 mRNA, thereby depleting the functional COX-2 mRNA available...
Book Chapter
Series: Endocrine Development
Volume: 22
Published: 30 July 2012
10.1159/000334304
EISBN: 978-3-8055-9337-3
... Abstract Premature development of breast and/or pubic hair in a prepubertal girl used to raise questions and concerns from the families. There is actually a wide range of clinical expressions of precocious puberty in girls and not all presentations are considered to be true precocious puberty...
Book Chapter
Series: Frontiers in Diabetes
Volume: 21
Published: 16 February 2012
10.1159/000334529
EISBN: 978-3-8055-9944-3
... in the regulatory regions of the SLC16A1 gene, which encodes the monocarboxylate transporter 1 (MCT-1) protein. MCT-1 transports lactate and pyruvate into the cell and is expressed in practically all cell types, except the pancreatic beta-cell where it is transcriptionally silenced. The pathogenesis of EIHI...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318494
EISBN: 978-3-8055-9445-5
... of onset of symptoms, basal prolactin, estradiol, and total testosterone levels, tumor size and Ki 67 expression in tumor tissue. Male patients were older. Visual defects were significantly more prevalent in men. Hardy 4 stage tumors were found only in men. We found no significant correlation between tumor...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 101
Published: 03 May 2010
10.1159/000314511
EISBN: 978-3-8055-9428-8
..., in particular those located in gene promoters. Studies on gene expression demonstrate stable effects on transcription [ 5 ]. Importantly, some of the genes which showed altered expression following prenatal undernutrition are transcription factors which affect multiple pathways in development and nutrient...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 101
Published: 03 May 2010
10.1159/000314515
EISBN: 978-3-8055-9428-8
... the ability to acquire brown adipocyte features under various stimuli [ 25 – 27 ]. So far, gene expression in human brown adipose tissue has only been investigated in one study [ 28 ]. Expression Profiling of Human Adipose Tissue during Diet-Induced Weight Loss Expression profiling using microarrays...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 101
Published: 03 May 2010
10.1159/000314517
EISBN: 978-3-8055-9428-8
... MicroRNAs (miRNAs) are small 21-25 nucleotide-long non-coding RNAs that have emerged as key negative post-transcriptional regulators of gene expression [ 1 , 2 ]. Currently there are more than 700 mammalian miRNAs that can potentially target up to one-third of protein-coding human genes [ 1...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 66
Published: 26 May 2009
10.1159/000218205
EISBN: 978-3-8055-9036-5
... silencing, focusing on its application to the inner ear. RNAi is a physiological phenomenon in which small, double-stranded RNA molecules (small interfering RNA, siRNA) reduce expression of homologous genes. Notable for its exquisite sequence specificity, it is ideally applied to diseases caused by a gain...
Book Chapter
Series: Forum of Nutrition
Volume: 61
Published: 27 April 2009
10.1159/000212735
EISBN: 978-3-8055-9098-3
... Abstract The impact of sesamin, episesamin and sesamolin (sesame lignans) on hepatic gene expression profiles was compared with a DNA microarray. Male Sprague-Dawley rats were fed experimental diets containing 0.2% sesamin, episesamin or sesamolin, and a control diet free of lignans for 15 days...
Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154858
EISBN: 978-3-8055-8629-0
... functions leading to chronic inflammation. Histamine also regulates monocytes, dendritic cells, T cells and B cells, as well as related antibody isotype responses. The diverse effects of histamine on immune regulation appear to be due to differential expression and regulation of four types of histamine...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317153
EISBN: 978-3-8055-9596-4
... and M15.2 lines to E. maxima infection with cellular immune responses, the expression levels of mRNAs encoding 14 immune-related molecules were measured by quantitative RT-PCR in intestinal intraepithelial lymphocytes (IELs) and splenocytes at 0, 3,4, and 5 days following parasite infection. Intestinal...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317155
EISBN: 978-3-8055-9596-4
..., and pooled spleen mRNA of R, S and non-challenged, control (C)chicks, several genes were identified with differential expression associated with host resistance to IBDV. These genes were also subjected to RT-PCR on individual samples to verify the results obtained from microarrays. The major finding...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317157
EISBN: 978-3-8055-9596-4
... by mechanisms that are not understood. We have employed Serial Analysis of Gene Expression (SAGE) to examine the global expression of genes in PRRSV-infected PAMs. Total cellular RNA was prepared from in vitro mock-infected and PRRSV strain VR-2332-infected PAMs at 0, 6, 12, 16 and 24 hours after infection...