... Abstract Aspirin exacerbated respiratory disease (AERD) has been defined as a non-steroidal anti-inflammatory drug (NSAID)-triggered hypersensitivity, non-allergic bronchial asthma and chronic rhinosinusitis (CRS) with nasal polyps. The underlying pathophysiology of AERD is not completely...

... Abstract Exacerbations are important events in patients with asthma and chronic obstructive pulmonarydisease (COPD). Reducing the number, frequency and the severity of exacerbations istherefore an important management goal identified by treatment guidelines for both diseases.There...

... Abstract Modeling acute exacerbations of chronic obstructive pulmonary disease (AECOPD) inanimals has proven challenging due to the clinical and pathological complexity of the underlyingdisease. This has hindered the progress in understanding the cellular and molecularmechanisms that lie...

... Abstract Chronic obstructive pulmonary disease (COPD) exacerbations are common events thatpunctuate the natural history of COPD contributing to disease severity progression and being themajor cause of COPD-related morbidity and mortality. Currently available pharmacologicalstrategies are only...

... Abstract Several respiratory viruses have been shown to cause exacerbations of asthma. While thevarious viral responses likely have common mechanisms of activation, the respiratory syncytialvirus (RSV) appears to promote specific responses that on their own can cause severe pulmonaryproblems...

...) and during exacerbationsof this disease. Cigarette smoke, which contains bioactive LPS, is the most common cause ofCOPD and may also precipitate exacerbations. In addition, the presence of Gram-negativebacteria in the lower airways is a distinguishing feature both of stable COPD and of exacerbations.Based...

... Abstract In both children and adults, rhinovirus (RV) infections remain a major cause of exacerbationsin asthma. With the use of both in vitro models of RV infection and experimentalmodels of asthma exacerbation in humans, insight into the precise role of RV in this processhas been obtained. RV...

... disease (no more severe than correspondingto the GOLD 2 stage of human COPD), and none of the models show the smokeindependentprogressive disease seen in humans with GOLD 3 or 4 COPD. There are nomodels of cigarette smoke-induced chronic bronchitis in animals and there are no modelsof acute exacerbations...

...) in Australian asthmatic patients. Thorax 2002;57:569-574. 8. Rajan JP, Wineinger NE, Stevenson DD, White AA: Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature. J Allergy Clin Immunol 2015;135:676-681.e1. 9. Berges-Gimeno MP, Simon RA...