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Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 127
Published: 01 February 2024
EISBN: 978-3-318-07341-6
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 93
Published: 26 February 2020
EISBN: 978-3-318-06649-4
... to effects of paternal nutrition mediated by epigenetic modifications in sperm. The epigenome is extensively remodeled in the early embryo. Attention has therefore focused on the periconceptional period as a time when differences in parental nutrition might influence the establishment of epigenetic marks...
Book Chapter
Series: Monographs in Human Genetics
Volume: 21
Published: 11 September 2017
EISBN: 978-3-318-06098-0
... Abstract Spermatogenesis describes a complex multistep differentiation process to produce millions of mature spermatozoa daily. Spermatogenesis is fueled by spermatogonial stem cells. It comprises a variety of unique genetic and epigenetic mechanisms to eventually generate haploid sperm, which...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 30
Published: 28 September 2015
EISBN: 978-3-318-05574-0
... - population genetics, cytogenetics and molecular technologies - specific genes have been implicated in mediating almost all aspects of nociception and mood disorders. The current review attempts to identify specific genes and epigenetic mechanisms common to both disorders. It is concluded that external...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 40
Published: 09 October 2014
EISBN: 978-3-318-02730-3
... propose a new candidate for an aging clock, based on epigenetics and the state of chromosome methylation, particularly in stem cells. If validated, this mechanism would present a challenging but not impossible target for medical intervention. To many readers, it will seem like a strange idea...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
EISBN: 978-3-318-02700-6
... happens through direct chemical modifications of the genome by so-called epigenetic modifications. These epigenetic modifications include DNA methylation and histone modifications. Recent studies focusing on the role of epigenetics in the pathogenesis of T2D suggest that alterations in the DNA methylation...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 71
Published: 24 January 2013
EISBN: 978-3-318-02270-4
... Abstract Fetal growth is a complex process involving environmental, epigenetic and genetic factors. Fetal growth restriction is associated with morbidity among small for gestational age (SGA) neonates as well as in children and adults who were former SGA. Imprinted genes (whose expression...
Book Chapter
Series: Contributions to Nephrology
Volume: 170
Published: 08 June 2011
EISBN: 978-3-8055-9743-2
... Abstract The incidence of diabetes and related complications like nephropathy is growing rapidly and has become a major health care issue. Changes in the environment and nutritional habits have been implicated as major players. Furthermore, it is becoming increasingly clear that epigenetic...
Book Chapter
Series: Endocrine Development
Volume: 14
Published: 26 February 2009
EISBN: 978-3-8055-9042-6
... Abstract Human growth is a complex process and requires the appropriate interaction of many members. Central members in the growth axes are regulated epigenetically and thereby reflect the profound significance of imprinting for correct mammalian ontogenesis. A prominent imprinting disorder...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 62
Published: 12 August 2008
EISBN: 978-3-8055-8554-5
... Abstract Epigenetics provides a potential explanation for how environmental factors modifythe risk for common diseases among individuals. Interindividual variation in DNAmethylation and epigenetic regulation has been reported at specific genomic regionsincluding transposable elements...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
EISBN: 978-3-8055-9596-4
... Abstract The modern version of epigenetics includes the molecular mechanisms that influence the phenotypic outcome of a gene or genome, in absence of changes to the underlying DNA sequence. A host of genomic interrelationships with the diet evidently exist. The broad topic of nutrigenomics...
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Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 126
Published: 23 May 2023
EISBN: 978-3-318-07246-4
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 97
Published: 12 May 2023
EISBN: 978-3-318-07170-2
... into diet-altering disease development by modulating processes involved with the onset, progression, and severity of disease. These factors affecting the development of these chronic diseases are thought to be mediated by epigenetic mechanisms, which are heritable and reversible, and carry genetic...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 125
Published: 27 April 2022
EISBN: 978-3-318-07043-9
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 123
Published: 14 September 2021
EISBN: 978-3-318-06929-7
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 120
Published: 25 February 2020
EISBN: 978-3-318-06651-7