Search Results for epidermal

... is organized in the form of a gradient in the epidermis with low concentrations in the stratum basale and peak concentrations in the stratum granulosum . During the aging process, this epidermal gradient collapses. In this chapter, we describe how a drop of calcium in the stratum granulosum affects...

... Abstract The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its correct function is required for normal skin development and homeostasis, while dysregulation of EGFR signalling results in cellular hyper-proliferation and defects in differentiation, leading to impaired...

... Abstract Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but severe adverse cutaneous drug reactions that are to be considered medical emergencies. The average reported mortality rate for SJS is 1–5%, and up to 25–35% for TEN. TEN and SJS are characterized by more...

... Abstract Toxic epidermal necrolysis (TEN) is a severe acute exfoliative skin disease characterized by detachment of large epidermal sheets as a result of massive keratinocyte apoptosis. Although TEN is mostly caused by drugs, how drug-related antigens are presented to T cells is not clarified...

... Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the most severe forms of hypersensitivity reactions affecting the skin. They are best considered severity variants of a single disease on the basis of similar pathology (epidermal necrolysis), risk factors, causes...

... line. Here we have expanded this observation to primary cultures of normal human epidermal keratinocytes. Treatment of these cells with TCDD resulted in increased expression of IL-1β mRNA. Both the magnitude and relative fold increase of levels of IL-1β mRNA were affected by specific culture conditions...