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epidermal

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Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
10.1159/000489521
EISBN: 978-3-318-06385-1
... is organized in the form of a gradient in the epidermis with low concentrations in the stratum basale and peak concentrations in the stratum granulosum . During the aging process, this epidermal gradient collapses. In this chapter, we describe how a drop of calcium in the stratum granulosum affects...
Book Chapter
Series: Current Problems in Dermatology
Volume: 46
Published: 22 December 2014
10.1159/000367959
EISBN: 978-3-318-02763-1
... Abstract The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its correct function is required for normal skin development and homeostasis, while dysregulation of EGFR signalling results in cellular hyper-proliferation and defects in differentiation, leading to impaired...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 97
Published: 07 May 2012
10.1159/000335627
EISBN: 978-3-8055-9971-9
... Abstract Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but severe adverse cutaneous drug reactions that are to be considered medical emergencies. The average reported mortality rate for SJS is 1–5%, and up to 25–35% for TEN. TEN and SJS are characterized by more...
Book Chapter
Published: 31 May 2007
10.1159/000104196
EISBN: 978-3-318-01454-9
... Abstract Toxic epidermal necrolysis (TEN) is a severe acute exfoliativeskin disease characterized by detachment of large epidermalsheets as a result of massive keratinocyte apoptosis.Although TEN is mostly caused by drugs, how drug-relatedantigens are presented to T cells is not clarified...
Book Chapter
Published: 31 May 2007
10.1159/000104206
EISBN: 978-3-318-01454-9
... Abstract Stevens-Johnson syndrome (SJS) and toxic epidermalnecrolysis (TEN) are the most severe forms of hypersensitivityreactions affecting the skin. They are best consideredseverity variants of a single disease on the basis of similarpathology (epidermal necrolysis), risk factors, causes...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 79
Published: 19 June 2001
10.1159/000058831
EISBN: 978-3-318-00683-4
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Published: 23 September 1994
10.1159/000424203
EISBN: 978-3-318-04635-9
... line. Here we have expanded this observation to primary cultures of normal human epidermal keratinocytes. Treatment of these cells with TCDD resulted in increased expression of IL-1β mRNA. Both the magnitude and relative fold increase of levels of IL-1β mRNA were affected by specific culture conditions...
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