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endothelial activation

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Book Chapter
Book Chapter
Book Chapter
Published: 05 December 1990
10.1159/000419684
EISBN: 978-3-318-05025-7
... are elicited by FMLP, ADP and PAF in a concentration-dependent manner, due to the activation and aggregation of neutrophils (PMN) and platelets. These effects can be antagonized by exogenously applied adenosine, PGE1 and PGE2 in physiological concentrations. Cultured vascular endothelial cells also inhibit...
Book Chapter
Published: 05 December 1990
10.1159/000419685
EISBN: 978-3-318-05025-7
... Abstract The capacity of pentoxifylline and some of its analogues to inhibit endothelial cell activation by tumor necrosis factor (TNF) was investigated. The drugs were added to endothelial cells during incubation with the cytokine. Thromboplastin activity, polymorphonuclear cell and two...
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170814
EISBN: 978-3-8055-8959-8
..., manifested by endothelialactivation’, multilamination of glomerular and peritubular capillary basement membranes, interstitial fibrosis and tubular atrophy, and sometimes chronic transplant arteriopathy. Diagnosis requires a biopsy and demonstration of the complement degradation product, C4d in peritubular...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 89
Published: 11 August 2005
10.1159/000087912
EISBN: 978-3-318-01248-4
... to leakage of increasing amounts of placental fragmentsand cytokines in the maternal circulation and an exaggerated systemic endothelial activation asidentified in preeclampsia. So far, treatment of preeclampsia is focused on signs like hypertension,whereas attempts of modifying immune responses may...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317148
EISBN: 978-3-8055-9596-4
... be through the high level of expression of A20 and inhibition of activation of NF-ĸB. BAECs are commonly used as a model to study endothelial cell function in many different systems. As shownhere, transcriptional and probable protein changes resulting from BVDV infection significantly alter cellular...
Book Chapter
Series: Contributions to Nephrology
Volume: 172
Published: 01 September 2011
EISBN: 978-3-8055-9795-1
... with microalbuminuria. Diabetologia 1996;39:1569-1576 3. Pfister F, Feng Y, vom HF, et al: Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes 2008;57:2495-2502 4. Rabelink TJ, de Boer HC, van Zonneveld AJ: Endothelial activation and circulating markers...
Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 172
Published: 01 September 2011
10.1159/000328703
EISBN: 978-3-8055-9795-1
... into myofibroblasts, and inflammatory cells are recruited to the vessel wall. While such phenomena may be an adaptation to ischemia, destabilization of the microvascular network ultimately leads to rarefaction and ischemic organ failure. Glomerular endothelial cell involvement, due to redox activation, hyperglycemia...
Book Chapter
Book Chapter
Published: 05 December 1990
10.1159/000419688
EISBN: 978-3-318-05025-7
... Abstract Endothelial cells are able to both inhibit or trigger thrombin generation through the expression of two essential membrane glycoproteins, thrombomodulin or tissue factor. Cytokines can induce a procoagulant state of the endothelium by increasing tissue factor activity and sometimes...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 99
Published: 21 October 2013
EISBN: 978-3-318-02481-4
...References References 1. Zlotnik A, Yoshie O: The chemokine superfamily revisited. Immunity 2012;36:705-716. 2. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M: The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004;25:677-686...
Book Chapter
Series: Contributions to Nephrology
Volume: 199
Published: 17 December 2021
10.1159/000517703
EISBN: 978-3-318-06937-2
... in the proximal tubules [ 25 ]. In SCD, the proximal tubular function is supra-normal, and it is likely that NGAL will be reabsorbed in greater proportions and, consequently, found in reduced urine levels. Endothelial activation and dysfunction play a central role in the pathophysiology of SCD, being related...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 99
Published: 21 October 2013
10.1159/000353317
EISBN: 978-3-318-02481-4
... infiltrate [ 13 ]. This evidence raise the interesting possibility that CXCR2 may not stimulate angiogenesis only through endothelial cell chemotaxis, but also by recruiting other growth-factor producing cells that may in turn activate phosphotyrosine receptors and angiogenic sprouting (fig. 2...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 99
Published: 21 October 2013
10.1159/000353311
EISBN: 978-3-318-02481-4
... that activates angiogenesis, or block the expression of its receptor on endothelial cells, and (2) agents that directly affected endothelial cell function or survival preventing endothelial cells from proliferating, migrating or avoiding cell death (table 2 ) [ 14 , 15 ]. Table 2 Direct and indirect...
Book Chapter
Series: Contributions to Nephrology
Volume: 174
Published: 15 September 2011
10.1159/000329382
EISBN: 978-3-8055-9811-8
... and inflammatory mediators stimulate epithelial and endothelial cells which in turn signal dendritic cells with activation of other immune effector cells. Transiting neutrophils and monocytes interact with the endothelium and further propagate inflammation. Dashed black arrows denote incoming signals and red solid...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 99
Published: 21 October 2013
10.1159/000353557
EISBN: 978-3-318-02481-4
... cells on endothelial activation. These data demonstrate the suppressive influences of Foxp3+ iTreg cells on endothelial activation and leukocyte recruitment, and provide a novel insight into their regulatory function at the site of inflammation. In the context of metabolic regulation of Treg cell...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 6
Published: 26 April 2018
10.1159/000485068
EISBN: 978-3-318-06313-4
... of SW, including Akt and extracellular signal-regulated kinase (ERK1/2), is indicated to regulate expression and activation of angiogenesis-associated protein endothelial nitric oxide synthase and VEGF. Additionally, the degradation and recycling of vascular endothelial growth factor receptor...
Book Chapter
Series: Contributions to Nephrology
Volume: 172
Published: 01 September 2011
10.1159/000328692
EISBN: 978-3-8055-9795-1
... ]. The investigators also observed a positive correlation between plasma ET-1 concentration and arterial blood pressure, consistent with a link between endothelial activation and plasma ET concentration in the context of acute poststreptococcal glomerulonephritis. Although elevated ET-1 plasma concentrations may...