1-20 of 3192 Search Results for

endothelial

Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Book Chapter
Book: Cornea
Series: ESASO Course Series
Volume: 6
Published: 11 August 2015
10.1159/000381496
EISBN: 978-3-318-05453-8
... Abstract The cornea remains in a state of deturgescence, maintained by the endothelial cell Na+/K+ ATPase and by tight junctions between endothelial cells that limit the entrance of fluid into the stroma. By maintaining an optimum level of corneal hydration, endothelial cells preserve...
Book Chapter
Book Chapter
Book Chapter
Book
Book Chapter
Book Chapter
Series: Frontiers in Diabetes
Volume: 27
Published: 18 June 2019
10.1159/000486268
EISBN: 978-3-318-06507-7
... Abstract Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents is the standard care for the treatment of diabetic macular oedema (DME). Anti-VEGF agents have been proven to be effective for DME based on the results of large clinical trials. However, a concern...
Book Chapter
Series: Contributions to Nephrology
Volume: 195
Published: 22 May 2018
10.1159/000486929
EISBN: 978-3-318-06350-9
... Abstract Background: In the traditional theory of albuminuria, small amounts of albumin pass through the fenestrae in glomerular endothelial cells, then through the slit membrane in the gaps between foot processes of glomerular epithelial cells. In the novel theory, large amounts of albumin...
Book Chapter
Series: Contributions to Nephrology
Volume: 192
Published: 08 February 2018
10.1159/000484278
EISBN: 978-3-318-06251-9
... and an activation of local inflammation, have been regarded as the mechanisms of UA-induced renal disease, which contribute to glomerular hypertrophy and interstitial fibrosis via endothelial dysfunction. However, there have been rare studies on the direct effect of UA on phenotype transition of renal cells...
Book Chapter
Series: Developments in Ophthalmology
Volume: 60
Published: 24 April 2017
10.1159/000459699
EISBN: 978-3-318-06042-3
... Abstract For decades, panretinal photocoagulation (PRP) has been the standard of care for the treatment of proliferative diabetic retinopathy (PDR). The relatively recent advent of anti-vascular endothelial growth factor (VEGF) formulations for intravitreal injection has provided a fresh...
Book Chapter
Series: Developments in Ophthalmology
Volume: 55
Published: 27 October 2015
10.1159/000431129
EISBN: 978-3-318-05565-8
... Abstract Systematic study of the mechanisms underlying pathological ocular neovascularization has yielded a wealth of knowledge about pro- and anti-angiogenic factors that modulate diseases such as neovascular age-related macular degeneration. The evidence implicating vascular endothelial...
Book Chapter
Series: ESASO Course Series
Volume: 2
Published: 15 August 2012
10.1159/000338155
EISBN: 978-3-318-02159-2
... with remarkable effects on visual improvement. Lately, new approaches in the treatment of DME have been considered; in particular the employment of anti-vascular endothelial growth factor (anti-VEGF) drugs. VEGF is a pluripotent growth factor that functions as a vasopermeability factor and an endothelial cell...
Book Chapter
Series: Contributions to Nephrology
Volume: 174
Published: 15 September 2011
10.1159/000329248
EISBN: 978-3-8055-9811-8
... Abstract Endothelial cells play a key role in initiating and propagating the inflammatory response seen in ischemia, infections and sepsis. Situated in a key position between the epithelial cells and white blood cells (WBC), they interact and respond to signals from both cell types...
Book Chapter
Series: Advances in Cardiology
Volume: 46
Published: 14 September 2011
10.1159/000325108
EISBN: 978-3-8055-9646-6
... Abstract Vascular endothelial dysfunction refers to a loss of normal homeostatic functions in the blood vessels. It is characterized by reduced vasodilation and enhanced vasoconstriction functions and chronic prothrombotic and inflammatory activity. There is convincing evidence for endothelial...
Book Chapter
Series: Contributions to Nephrology
Volume: 170
Published: 08 June 2011
10.1159/000324954
EISBN: 978-3-8055-9743-2
... lacking endothelial nitric oxide synthase (eNOS). Diabetic eNOS knockout mice develop severe renal injuries resembling advanced human diabetic nephropathy. This model thereby suggests a key role for reduced nitric oxide levels in the pathogenesis of diabetic nephropathy. In this article, we summarize...
Book Chapter
Book: Anti-VEGF
Series: Developments in Ophthalmology
Volume: 46
Published: 13 August 2010
10.1159/000320007
EISBN: 978-3-8055-9530-8
.... The introduction of new intravitreally injectable inhibitors of vascular endothelial growth factor (VEGF) revolutionized the management of the wet form. Pegaptanib was the first anti-VEGF agent to be approved by the US Food and Drug Administration (FDA) for use in neovascular AMD. The VISION study showed...
Book Chapter
Book: Anti-VEGF
Series: Developments in Ophthalmology
Volume: 46
Published: 13 August 2010
10.1159/000320008
EISBN: 978-3-8055-9530-8
... and, more specifically, the therapy employing antivascular endothelial growth factor (anti-VEGF) drugs could play a meaningful role. VEGF is a pluripotent growth factor that functions as an endothelial cell-specific mitogen and vasopermeability factor. Through these mechanisms VEGF plays a critical role...
Book Chapter
Book: Anti-VEGF
Series: Developments in Ophthalmology
Volume: 46
Published: 13 August 2010
10.1159/000320010
EISBN: 978-3-8055-9530-8
... Abstract Choroidal neovascularization (CNV) is the most common vision-threatening macular complication in pathologic myopia (PM) being detectable in 4–11% of the affected eyes. Treatment of PM-related CNV is still controversial. Intravitreal injections of antivascular endothelial growth factor...
Book Chapter
Book: Anti-VEGF
Series: Developments in Ophthalmology
Volume: 46
Published: 13 August 2010
10.1159/000320011
EISBN: 978-3-8055-9530-8
... histoplasmosis syndrome, Beçhet’s disease, multiple evanescent white dot syndrome, birdshot chorioretinopathy, acute multifocal posterior placoid pigment epitheliopathy, serpiginous choroiditis, and persistent placoid maculopathy. Results that have reported on antivascular endothelial growth factor (anti-VEGF...
Book Chapter
Book: Anti-VEGF
Series: Developments in Ophthalmology
Volume: 46
Published: 13 August 2010
10.1159/000320012
EISBN: 978-3-8055-9530-8
... (CNV). This exudative disease of the central retina leads to loss of visual acuity, and results of treatments in the past have been disappointing. From the present evidence it may be concluded that intravitreal antivascular endothelial growth factor (anti-VEGF) therapy with ranibizumab or bevacizumaab...