... transduction mechanism of elastin peptide receptor in human leucocytes. FEBS 1989;258:5-8. 11. Hill SJ, Kendall DA: Cross-talk between different receptor-effector systems in the mammalian CNS. Cell Signal 1989;1:135-141. 12. Axelrod J, Burch RM: Receptor-mediated activation of phospholipase A2 via GTP...

... triphosphate) which mediates Ca 2+ release followed by the physiological response, as shown for the elastin receptor (ER) [ 10 ]. We shall come back later to the Ca-activating pathway which was shown to be involved in the age-dependent decline of several receptors. In the case discussed above, it was of great...

... with both methods are discussed. Follows then the description of age changes of macromolecular components of extracellular matrix as well as the decline with age of receptor-mediated cell-matrix interactions. These interactions mediated by several types of receptors, as integrins, the elastin receptor...

... not proven a significant difference between them. Stem cells are cells with the ability to reproduce themselves and differentiate into different tissues, therefore potentially having a superior ability to stimulate collagen, elastin, and epidermis. However, conditioned media from these cells have not proven...

... KM (eds): Extracellular Matrix Biology. Cold Spring Harbor Perspectives in Biology. New York, Cold Spring Harbor Laboratory Press, 2012, pp 45-63. 8. Robert L, Hornebeck W (eds): Elastin and Elastases. Boca Raton, ICRC Press, 1989, vol 1. 9. Kielty CM, Sherratt MJ, Shuttelworth CA: Elastic...

... to that of fractional lasers, namely to induce neocollagenesis by thermal effects within the dermis. The fractional thermal injury of deep dermal collagen induces a vigorous wound healing process with dermal remodeling and the generation of new collagen, elastin and hyaluronic acid. The major benefit of minimally...

... endothelial antithrombogenic properties, increased reactive oxygen species generation, inflammatory signaling and migration of VSMCs to the subintimal space, impaired angiogenesis and increased elastin degradation. The key initiating step in atherogenesis is subendothelial accumulation of apolipoprotein B...

.... As often mentioned by Robert, cells were considered up to the end of 1970s as producing the ECM, as if they were functionally independent of it. In connective tissues, the ECM is composed of two classes of macromolecules: proteoglycans and fibrous proteins like collagen, elastin, fibronectin or laminin...

... of most species. This is true even in protected environments as shown by animals kept in laboratories or zoos, dying mostly of malignant tumors or other fatal diseases. Let us get back to tinkering. One well-studied example is the aging of elastin and its role in the age-dependent decline...

.... Oxford, Oxford University Press, 1999. 7. Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-636. 8. Noble D: The Music of Life. Biology beyond the Genome. Oxford, Oxford University Press, 2006. 9. Robert L, Fülop T: Effect of elastin peptides...

... to the distribution of lesions associated with age-related macular degeneration. Am J Pathol 2005;166:241-251. 13. Sivaprasad S, Chong NV, Bailey TA: Serum elastin-derived peptides in age-related macular degeneration. Invest Ophthalmol Vis Sci 2005;46:3046-3051. 14. Chau KY, Sivaprasad S, Patel N, et al...

...-links between colagen and elastin hold substantialpromise. ...

... with increased effective stiffnesscaused by the corresponding changes in content of collagen, elastin, and VSM in thevascular wall. Intermediate conduit arteries also dilate with age but their functional characteristicsremain relatively preserved. In the microcirculation, vasoconstriction, VSMhypertrophy...

... to be major determinants of arterial stiffness. Thus, quantitativeand qualitative alterations of collagen and elastin fibers are involved in arterial stiffeningthat is associated with the aging process and disease states such as hypertension, diabetes,atherosclerosis, and chronic renal failure. Elucidation...

... cytokinesand advanced glycosylation end-products. Likewise, aging may increase arterialstiffening by altering the proportions of elastin and collagen in the aorta. The consequencesof arterial stiffening are increased pulse pressure, hypertension, and a greater riskof cardiovascular disease. Treatment...

..., John Wiley & Sons, 2007. 25. Comfort A: The Biology of Senescence. London, Churchill Livingstone, 1979. 26. Robert L, Robert AM, Fülöp T: Rapid increase in human life expectancy: will it soon be limited by the aging of elastin? Biogerontology 2008;9:119-133. 27. Jacob M-P, Hornebeck W...

.... Circulation 1962;27:1235-1240 17. Ewart AK, Morris CA, Atkinson D, Jin W, Sternes K, et al: Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome. Nat Genet 1993;5:11 18. Morris CA, Demsey SA, Leonard CO, Dilts C, Blackburn BL: Natural history of Williams syndrome: physical...