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Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170787
EISBN: 978-3-8055-8959-8
... weeks posttransplant). The advent of more sensible and specific techniques of detection of anti-HLA antibodies (such as ELISA or Luminex techniques) has questioned this dogma, with a number of reports showing that transplantation, despite the presence of an donor-specific antibody (DSA), could be done...
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170788
EISBN: 978-3-8055-8959-8
... weeks posttransplant). The advent of more sensible and specific techniques of detection of anti-HLA antibodies (such as ELISA or Luminex techniques) has questioned this dogma, with a number of reports showing that transplantation, despite the presence of an donor-specific antibody (DSA), could be done...
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170841
EISBN: 978-3-8055-8959-8
... Abstract Numerous retrospective and prospective studies have been conducted to determine the prevalence and significance on long-term graft survival of de novo post-transplant donor-specific antibodies (DSA), directed against both HLA and non-HLA molecules. Moreover, it has been postulated...
Book Chapter
Series: Contributions to Nephrology
Volume: 190
Published: 29 May 2017
10.1159/000468962
EISBN: 978-3-318-06061-4
... are not standardized and poor evidence is currently available on the effectiveness of therapy regimens with combinations of drugs. Standard treatment for acute AMR is based on 3 cornerstones: removal of donor-specific antibodies (DSAs) from the bloodstream, reduction of DSAs synthesis, and inhibition...
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170843
EISBN: 978-3-8055-8959-8
... Abstract Patients undergoing renal transplantation frequently have non-donor-specific HLA antibodies (NDSA). There could be NDSA (e.g. a negative crossmatch in a sensitized patient), or could be donor-specific HLA antibodies (DSA) (e.g., antibody-incompatible transplantation). NDSA levels...
Book Chapter
Series: Contributions to Nephrology
Volume: 146
Published: 28 October 2004
10.1159/000082057
EISBN: 978-3-318-01168-5
... specific anti-HLA antibodies (DSA) are also associated with pooroutcome. Technological advances in tissue typing permit the detection of low levels of DSAnot seen with standard cytotoxicity cross-match tests. These tests which previously wereused to screen patients to avoid transplantation of donor...
Book Chapter
Series: Contributions to Nephrology
Volume: 190
Published: 29 May 2017
10.1159/000468967
EISBN: 978-3-318-06061-4
... be tailored to optimize the outcome for each recipient. Currently, immunosuppression is guided by relatively rudimentary strategies including epidemiologic parameters (e.g., age and self-declared race), human leukocyte antigen (HLA) mismatch, and donor-specific anti-HLA antibody (DSAs) screening. Development...
Book
Book Cover Image
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/isbn.978-3-8055-8959-8
EISBN: 978-3-8055-8959-8
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 40
Published: 12 December 2016
10.1159/000448308
EISBN: 978-3-318-02759-4
... Abstract Angiography is a useful, important, common imaging method, with digital subtraction angiography (DSA) remaining the gold standard for luminal imaging. Computed tomography angiography (CTA) is minimally invasive and quite accurate in the evaluation of stenosis. Magnetic resonance...
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170810
EISBN: 978-3-8055-8959-8
... Abstract Recent desensitization protocols using the combination of plasmapheresis (PP) or immunoadsorption to remove donor-specific anti-HLA antibodies (DSA) and/or intravenous immunoglobulin (IVIG) and rituximab to downregulate antibody-mediated immune responses have made kidney...
Book Chapter
Series: Contributions to Nephrology
Volume: 162
Published: 28 October 2008
10.1159/000170844
EISBN: 978-3-8055-8959-8
..., the usual persistence of donor-specific antibodies (DSA) post-transplanta-tion rather than to produce an accommodation state is associated to development of trans-plant glomerulopathy and then to a progressive renal allograft function deterioration. Thus, novel strategies are needed to prolong graft...
Book Chapter
Series: Radiosurgery
Volume: 6
Published: 15 May 2006
10.1159/000093712
EISBN: 978-3-318-01336-8
... with known target points have been designed to determine the geometricalaccuracy of stereotactic imaging modalities. Two phantoms are made of 8 PMMAplates, which fit into the stereotactic frame and are imaged together with the appropriatefiducial marker box. The CT/DSA phantom holds 45 steel spheres...
Book Chapter
Series: Contributions to Nephrology
Volume: 190
Published: 29 May 2017
10.1159/000468963
EISBN: 978-3-318-06061-4
... with CNI exclusively. Current protocols use lower CNI through levels, but it is important to consider that tacrolimus remains the cornerstone of immunosuppression in kidney transplantation. Indeed, CNI withdrawal studies have shown a high rate of de novo donor-specific antibodies (DSA) development...
Book Chapter
Series: Current Problems in Dermatology
Volume: 43
Published: 29 February 2012
10.1159/000335153
EISBN: 978-3-8055-9856-9
... also been used for desensitization in patients with either high titers of human leukocyte antigen (HLA) antibodies [ 18 , 19 ] or donor-specific HLA antibodies (HLA-DSA) [ 20 ], patients at high risk for AMR and allograft loss. Results were quite variable with acute rejection rates between 20 and 50...
Book Chapter
Series: Contributions to Nephrology
Volume: 184
Published: 11 February 2015
10.1159/000365823
EISBN: 978-3-318-02706-8
... the X-ray tube and the patient, and by minimizing the distance between the patient and the X-ray detector. Surgeons have to control exposure time (beam-on-time). Different projections reduce skin dose of smaller areas (fig. 3 , 4 ). Fig. 3 Diagnostic DSA prior to intervention; image of fistula...
Book
Book Cover Image
Published: 25 October 1993
10.1159/isbn.978-3-318-04811-7
EISBN: 978-3-318-04811-7