... Abstract Stereotactic body radiation therapy (SBRT) is a potent noninvasive means of administering high-dose radiation to demarcated tumor deposits in extracranial locations. The treatments use image guidance and related treatment delivery technology for the purpose of escalating the radiation...

... system.Comparing both modes of application of ifosfamide with mesna, we suggest that the single-dose infusion over 24 h leads to less total excretion of brush border enzymes during the collection period. ...

... Abstract Recent advances in the development of sorbent materials have enabled the development of hemoperfusion (HP). However, HP dose and prescription are not standardized and there is no consensus in clinical practice guidelines. Adequate prescription and modality are of utmost importance...

... Abstract This chapter focuses on the definitions and impact of prescription and delivery of the right dose of treatment in patients on continuous renal replacement therapy (CRRT). We define “dose” and the concepts of efficiency, intensity, and efficacy; differentiate their multiple components...

... of gastrointestinal conditions. However, studies have been very heterogeneous and conclusions are often hard to draw. An issue which has been grossly neglected appears to be that of pharmacokinetics. In fact, studies addressing any type of dose-effect relationship are extremely limited, and drawing conclusions...

... using higher doses ( > 35 ml/kg/h) or daily dialysis, more recent and much larger trials have shown that intensities in the range of 20–25 ml/kg/h or alternate day dialysis may be sufficient. This review attempts to explain these discrepant findings by critically reappraising several issues including...

... or hemofiltration, for the supportive management of AKI. On the other hand, the use of peritoneal dialysis (PD) is widespread in developing countries in view of its ease of use, low cost and minimal requirements on infrastructure. The dose of dialysis required for AKI remains controversial, although an augmented...

... proportional hazards model was used to evaluate correlationsbetween certain variables and ST. The independent variables evaluated were patient factors (age inyears and performance status), tumor factors (total volume and number of tumors in each patient), treatmentfactors (TCP, NTCP and marginal dose...

... Abstract Elaborate methods of patient imaging for diagnostics, dose calculation, and radiation delivery are currently used to develop treatment plans with highly conformal patient dose distributions. However, the true delivered dose likely deviates from the planned distribution due...

.... This is a primary requirement for the accurate delivery of complex IMRT treatment plans, which give differential radiation doses to various target volumes while conformally avoiding normal critical structures. In particular, image guidance using MV CT allows for direct target position verification with the patient...

... Abstract Introducing new technologies into radiation oncology clinical practices poses very specific logistical dilemmas. How do we determine that a new technology’s dose distribution is better than the ‘standard’ and what are the methods that can be applied to easily compare the ‘new...

..., and documentation of the demographics of acute renal failure anddialysis. One of the most recent and potentially interesting aspects of IT implementation onacute dialysis might be the renal replacement dose monitoring and calculation: close controlof the therapy delivery and, eventually, prescription adjustments...

... Abstract Background: Current practices for renal replacement therapy (RRT) in ICU remainpoorly defined. The observational DOse REsponse Multicentre International collaborativeinitiative (DO-RE-MI) survey addresses the issue of how the different modes of RRT are currentlychosen and performed...