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Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 127
Published: 01 February 2024
10.1159/000535177
EISBN: 978-3-318-07341-6
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 88
Published: 30 May 2017
10.1159/000455211
EISBN: 978-3-318-06031-7
... Abstract Epigenetics can be defined as stable, potentially heritable changes in cellular phenotype caused by mechanisms other than alterations in the underlying DNA sequence. DNA methylation is amongst the most intensely studied epigenetic mechanisms and has been shown to play a major role...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382058
EISBN: 978-3-318-05497-2
... Abstract Neuroblastoma is a childhood cancer entity dominated by DNA copy number alterations. Distinct recurrent patterns of chromosomal aberrations (i.e. deletions 1p, 3p and 11q and 17q gain) have been linked to prognosis and have been the subject of many studies in the search for driver...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000403885
EISBN: 978-3-318-02773-0
.... This chapter focuses on the importance of novel biomarkers: microRNA and microRNA inhibitors; DNA methylation and epigenetics, and immunotherapy and virotherapy to develop novel treatments for NETs. Novel Biomarkers Our understanding of neuroendocrine tumor (NET) biology and treatments has changed...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 5
Published: 22 December 2014
10.1159/000366568
EISBN: 978-3-318-02732-7
... Abstract All living cells, including tissue-specific stem cells, are constantly exposed to DNA damage, such as altered DNA bases and DNA double-strand breaks. Experimental evidence suggests that DNA damage checkpoint genes not only influence stem cell function in response to DNA damage but also...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 3
Published: 27 September 2012
10.1159/000338016
EISBN: 978-3-318-02171-4
... Abstract A multitude of sources induce lesions in cellular DNA. If left unrepaired, these DNA damages have the potential to trigger mutations and chromosomal aberrations that can initiate carcinogenesis. Cellular surveillance systems sense the presence of DNA damage and induce DNA damage...
Book
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Series: Genome Dynamics
Volume: 7
Published: 27 June 2012
10.1159/isbn.978-3-318-02150-9
EISBN: 978-3-318-02150-9
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324638
EISBN: 978-3-8055-9723-4
... Abstract Many people all over the world suffer from allergic rhinitis, induced by Th2 responses. CpG DNA, containing a central unmethylated C-G dinucleotide, promotes Th1 responses. Consequently, Th2 responses decrease. Systemic administration of CpG DNA could attenuate allergic rhinitis...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 1
Published: 22 April 2010
10.1159/000312653
EISBN: 978-3-8055-9244-4
... Abstract Several lines of evidence suggest that the accumulation of DNA damage contributes to organismal aging. Telomere dysfunction, replication errors and toxic metabolites (possibly including reactive oxygen species) represent some of the causes contributing to DNA damage accumulation during...
Book Chapter
Book Chapter
Book Chapter
Series: Genome Dynamics
Volume: 3
Published: 13 September 2007
10.1159/000107603
EISBN: 978-3-8055-8341-1
... Abstract We present an overview of comparative genomics of ATP-dependent DNA packagingsystems of viruses. Several distinct ATPase motors and accessory proteins have been identifiedin DNA-packaging systems of viruses such as terminase-portal systems, the φ29-likepackaging apparatus...
Book Chapter
Series: Genome Dynamics
Volume: 3
Published: 13 September 2007
10.1159/000107608
EISBN: 978-3-8055-8341-1
... at the DNA level. While theformation of chimeric genes has been shown to be an important way in which coding regionsof the genome evolve, many of the detailed studies have been limited to chimeric genesformed through retroposition events (through an RNA intermediate step). Here we provide ashort review...
Book Chapter
Book Chapter
Published: 31 July 2006
10.1159/000095017
EISBN: 978-3-318-01338-2
... (Cr-PdG), is formed from thereaction of acetaldehyde and DNA. We compare the mechanism of formation and biologicalproperties of this adduct with another, well known acetaldehyde-DNA adduct, N 2 -ethyl-dG,and describe how the genotoxic properties of the Cr-PdG adduct can explain many of theknown...
Book Chapter
Series: Genome Dynamics
Volume: 1
Published: 27 March 2006
10.1159/000092500
EISBN: 978-3-318-01290-3
... Abstract Oxidative damage to DNA has been examined in many non-malignant conditions, inmost cases for its utility as a marker of oxidative stress. Whilst this may prove useful,attempts to answer the question - why might oxidative damage be important in this disease? -would provide added value...