... Abstract The Dialogue on Diabetes and Depression (DDD) is an international collaborative effort to address the problems related to the comorbidity of depression and diabetes. The Association for the Improvement of Mental Health Programmes, a Swiss-based NGO, established the DDD to raise...

... Abstract Both glucocorticoids and inflammation have been implicated in the pathogenesis of depression. There is a large body of literature indicating that hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and glucocorticoid receptor (GR) dysfunction are present in a significant...

... Abstract Clinical Background: Mental disorders, especially depression, are associated with several comorbidities in the kidneys. Depression is the psychiatric disorder that mostly affects individuals with chronic kidney disease (CKD) and end-stage kidney disease. Epidemiology...

... Abstract Psychopathology has been closely related with artists. A link between creativity and a tendency to affective disorders has become widely accepted. Several studies have shown that artists suffer disproportionately high rates of mood disorders, particularly manic depression and major...

... Abstract Epidemiological studies implicate chronic depression as a predisposing factor for dementia in later life. However, the link is incompletely understood and controversial. The aim of this review is to consider some of the biological factors that contribute to neuroprogressive brain...

... Abstract A significant proportion of patients diagnosed with major depressive disorder (MDD) encounter frequent hospitalization because of suicidal ideation or after attempting suicide. Moreover, a significant proportion of subjects with MDD commit suicide. As a result, MDD-related suicide...

... Abstract Co-morbid depression and chronic pain are highly prevalent. The purpose of this review is to examine the role of chronic inflammation as a common mediator of these co-morbidities. Dysfunctional bidirectional pathways between the brain and the immune, endocrine and neurotransmitter...

... Abstract Depression and chronic pain have been estimated to co-occur in up to 80% of patients suffering from these disorders, with this co-morbidity being more disabling and more expensive to both patients and society than either disorder alone. A number of neural substrates have been proposed...

... response' is also similar in nature to some of the defining characteristics of the depressed state of affective disorder. In this review, we explore links that may relate the co-existence of depression in neuropathic pain patients with the activity of cytokines and discuss the role of several key pro...

... on the monoamine neurotransmitters noradrenaline, 5-hydroxytryptamine (5-HT, serotonin), and dopamine and the amino acid neurotransmitters GABA (γ-aminobutyric acid) and glutamate in chronic pain and depression. Numerous preclinical and clinical neurochemical, neuroanatomical, pharmacological and molecular...

... Abstract Comorbidity between major depressive disorder (MDD), anxiety (generalized anxiety, panic disorder, social anxiety disorder) and pain is a major complicating factor in the diagnosis and treatment of psychiatric and neurological disorders. Although numerous neurotransmitters...

... Abstract Diabetes and depression provide a model for understanding the comorbidity of mental and physical disorders, as each influences the other while sharing a broad range of biological, psychological, socioeconomic and cultural determinants. Diabetes and depression may be viewed as: (1...

... Abstract Depression, diabetes and dementia are three disorders associated with staggering morbidity and mortality worldwide. The association between depression and diabetes has been well established. Furthermore, both depression and diabetes have been shown to increase the incidence of dementia...

... (BDNF) or by testing multiple candidates simultaneously. Notwithstanding the amount of suggestive evidence for depression, no real biomarker application has made an impact on clinical practice so far. Relatively consistent findings have been obtained for a few candidate proteins, such as BDNF - which...

... Abstract Major depressive disorder (MDD) is a widespread and disabling disease whose aetiology and pathophysiological basis are still incompletely understood. In this review, hypothesis-free proteomic analyses carried out on animal models of MDD to study the neurobiological correlates of MDD...