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Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522458
EISBN: 978-3-318-07054-5
... The observations that a biomarker of life and death undergoes augmentation followed by reduction and disappearance during the progression towards brain stem death in experimental animal models open the vista to search for both pro-life and pro-death cellular and molecular programs...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522464
EISBN: 978-3-318-07054-5
... ]. We became interested in the PI3K/Akt cascade when this signaling pathway is reported to participate in brain stem cardiovascular regulation [ 6‒10 ]. We reasoned that given that cancer is one of the major global causes of death and brain stem death is a fatal eventuality, they may share a common...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522449
EISBN: 978-3-318-07054-5
... We embarked on our journey to study brain stem death because of an opportune finding three decades ago. We were then at the initial stage of testing the clinical application in the intensive care unit of our newly developed computer algorithm [ 1 ] that offers continuous, on-line, real-time...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522457
EISBN: 978-3-318-07054-5
... Our discovery that the power density of sympathetic vasomotor components of blood pressure (BP) spectrum may serve as a prognostic marker for brain stem death is of clinical significance. At the same time, we recognize that advancement of medical management of life and death based...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522459
EISBN: 978-3-318-07054-5
... The realization that formation of peroxynitrite via a reaction between nitric oxide synthase II (NOS II)-generated NO and superoxide (O 2 • – ) underpins the pro-death process during brain stem death prompted us to search for the source of this reactive oxygen species (ROS) in the rostral...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522460
EISBN: 978-3-318-07054-5
... ]. Given that death posts the most severe threat to existence, we undertook a series of studies in early 2000s on HSPs, and found that at least HSP60 and HSP70 in the rostral ventrolateral medulla (RVLM) play a pro-life role during brain stem death. 6.1. Heat Shock Proteins as Molecular Chaperones...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522461
EISBN: 978-3-318-07054-5
... a series of adaptive responses. Thus, it is generally contended that hypoxia serves as the culprit for many abnormal brain functions. Two lines of evidence suggest that hypoxia plays a critical role during brain stem death. First, hypoxia occurs at the rostral ventrolateral medulla (RVLM) during...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522462
EISBN: 978-3-318-07054-5
... that most proteins in the cytosol and nucleus of eukaryotic cells are degraded via the ubiquitin-proteasome system (UPS), in an energy-dependent, highly complex, temporally controlled, and tightly regulated process that plays a major role in a variety of basic cellular processes during life and death...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522463
EISBN: 978-3-318-07054-5
... with the realization that reduction in tissue oxygen level occurs during experimental brain stem death [ 8‒10 ], and acute hypoxia induces expression of SUMO-1 [ 11 ]. In addition, we noted that hypoxia-inducible factor-1α (HIF-1α) and nuclear factor-κB (NF-κB), two important players that underpin brain stem death...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522465
EISBN: 978-3-318-07054-5
.... As the fundamental mechanism responsible for the maintenance of BP and HR, the eventuality of impairment of baroreflex may vary from inconvenience in daily existence to serious curtailment of mobility to death. It follows that studying baroreflex functionality during brain stem death is of vital importance. A golden...
Book
Book Chapter
Published: 13 August 2018
10.1159/000493593
EISBN: 978-1-912776-14-6
Book Chapter
Series: Contributions to Nephrology
Volume: 196
Published: 09 August 2018
10.1159/000485690
EISBN: 978-3-318-06298-4
... Abstract Background: Recent lines of evidence suggest that, as in other countries, sudden cardiac death (SCD) is more common in the Japanese dialysis clinical setting than we previously thought. Summary: Three specific important findings may underlie the increased incidence of SCD...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382089
EISBN: 978-3-318-05497-2
... Abstract Programmed cell death represents a fundamental cellular process that is highly conserved throughout evolution and involved in the regulation of various physiological and pathophysiological conditions. Apoptosis is currently one of the best characterized modes of programmed cell death...
Book
Book Cover Image
Series: World Review of Nutrition and Dietetics
Volume: 104
Published: 04 September 2012
10.1159/isbn.978-3-318-02189-9
EISBN: 978-3-318-02189-9
Book Chapter
Series: Medicine and Sport Science
Volume: 56
Published: 22 December 2010
10.1159/000320647
EISBN: 978-3-8055-9551-3
... Abstract Strategies for preventing sudden cardiac death in young athletes are predicated on the assumption that: (1) these events reflect pre-existing, clinically silent heart disease, and (2) means for detecting these abnormalities on the pre-participation evaluation are both feasible...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 29
Published: 07 October 2010
10.1159/000321773
EISBN: 978-3-8055-9557-5
... only shortly before his death in 1893 [ 5 ]. In the preface to Pierre Janet's dissertation, ‘The mental state of hysterics’ [ 9 ], Charcot wrote that hysteria is ‘largely a mental disease’. However, this was a concept which would crystallize only later, mainly with Pierre Janet himself and with Sigmund...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 29
Published: 07 October 2010
10.1159/000321786
EISBN: 978-3-8055-9557-5
... Joffroy (1844–1908) as co-editor from 1889, and was published in Paris by Masson. After Vulpian's death, his name disappeared in 1888; Brown-Séquard and Charcot remained the only editors, and Paul Regnard (1850– 1927) joined Alix Joffroy as co-editor. In 1889, Charcot's name disappeared, due...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 27
Published: 01 April 2010
10.1159/000311201
EISBN: 978-3-8055-9331-1
... the circumstances of his suicide at 61 as the outcome of accumulated physical deterioration, emotional distress and cognitive decline. Special attention is paid to the war wound he suffered in 1918, which seemed to involve a peculiar altered state of consciousness sometimes called ‘near-death experience’. The out...
Book Chapter
Series: Contributions to Nephrology
Volume: 163
Published: 15 June 2009
10.1159/000223778
EISBN: 978-3-8055-9203-1
... Abstract Aims: To offer a condensed description of the modes of cell death and the involved mechanisms behind them as detected in the different layers of the peritoneal tissue during experimental and clinical, long-term peritoneal dialysis (PD). Main Remarks: Several types of cell death...