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Book Chapter
Series: Contributions to Nephrology
Volume: 199
Published: 17 December 2021
10.1159/000517694
EISBN: 978-3-318-06937-2
.... Challenges: It is of the utmost importance to recognize and adequately manage kidney injuries secondary to automobile events, since their timely identification can prevent permanent damage to the organ and, at times, save lives. Prevention and Treatment: An approach with a focus on traffic safety...
Book Chapter
Series: Contributions to Nephrology
Volume: 192
Published: 08 February 2018
10.1159/000484276
EISBN: 978-3-318-06251-9
... Abstract Background: Hyperuricemia is a risk factor for causing end-stage kidney disease and cardiovascular disease in the general population; however, several aspects, such as the site of kidney damaged by hyperuricemia and the threshold levels of serum uric acid for the development...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 5
Published: 22 December 2014
10.1159/000366568
EISBN: 978-3-318-02732-7
... Abstract All living cells, including tissue-specific stem cells, are constantly exposed to DNA damage, such as altered DNA bases and DNA double-strand breaks. Experimental evidence suggests that DNA damage checkpoint genes not only influence stem cell function in response to DNA damage but also...
Book
Book Cover Image
Series: Frontiers of Neurology and Neuroscience
Volume: 32
Published: 03 July 2013
10.1159/isbn.978-3-318-02309-1
EISBN: 978-3-318-02309-1
Book Chapter
Series: Contributions to Nephrology
Volume: 182
Published: 14 May 2013
10.1159/000349964
EISBN: 978-3-318-02407-4
... Abstract Acute kidney injury (AKI) is a common but complex clinical syndrome with multiple etiologies. These etiologies target different sites and pathways within the kidney. Novel biomarkers of ‘kidney damage' (which can be tubular or glomerular) can be used to diagnose AKI, even...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 3
Published: 27 September 2012
10.1159/000338016
EISBN: 978-3-318-02171-4
... Abstract A multitude of sources induce lesions in cellular DNA. If left unrepaired, these DNA damages have the potential to trigger mutations and chromosomal aberrations that can initiate carcinogenesis. Cellular surveillance systems sense the presence of DNA damage and induce DNA damage...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338368
EISBN: 978-3-318-02184-4
... Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, decrease mucosal prostaglandin (PG) E 2 content by inhibiting cyclooxygenase (COX) activity and cause damage in the small intestine. The development of these lesions required the inhibition of both COX-1 and COX-2...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338377
EISBN: 978-3-318-02184-4
... Abstract In humans, nonsteroidal anti-inflammatory drugs (NSAIDs) cause mucosal damage in the small intestine as well as in the stomach and duodenum. Gastric and duodenal lesions caused by NSAIDs can be effectively treated with antisecretory agents; however, there are few effective agents...
Book Chapter
Series: Contributions to Nephrology
Volume: 174
Published: 15 September 2011
10.1159/000329382
EISBN: 978-3-8055-9811-8
... are urgently needed. In this review we will argue that (1) injury to the kidney is largely derived from local inflammation, (2) the triggers for this inflammation are derived from remote tissue damage, and (3) treatment directed at blocking damage signals or suppressing the response to them can attenuate...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 1
Published: 22 April 2010
10.1159/000312653
EISBN: 978-3-8055-9244-4
... Abstract Several lines of evidence suggest that the accumulation of DNA damage contributes to organismal aging. Telomere dysfunction, replication errors and toxic metabolites (possibly including reactive oxygen species) represent some of the causes contributing to DNA damage accumulation during...
Book Chapter
Book Chapter
Series: Forum of Nutrition
Volume: 61
Published: 27 April 2009
10.1159/000212745
EISBN: 978-3-8055-9098-3
...-induced neuronal cell damage system. The treatment with DHA hydroperoxide (DHA-OOH) or 6-hydroxydopamine (6-OHDA), either of which is a reactive oxygen species (ROS)-inducing neurotoxin, led to a significant decrease in viable dopaminergic SH-SY5Y cells by the MTT assay, whereas a significant protection...
Book Chapter
Series: Contributions to Nephrology
Volume: 161
Published: 30 May 2008
10.1159/000130412
EISBN: 978-3-8055-8567-5
... patients show a microinflammatory state with an increasedpercentage of CD14+/CD16+ monocytes in peripheral blood, even in patients who do notshow clinical evidence of inflammatory disease. However, the role played by these microinflammatorycells on the endothelial damage that precede the development...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 22
Published: 22 May 2007
10.1159/000102822
EISBN: 978-3-318-01450-1
Book Chapter
Series: Contributions to Nephrology
Volume: 153
Published: 03 November 2006
10.1159/000096761
EISBN: 978-3-318-01397-9
... Abstract The kidney is a target organ in plasma cell dyscrasias. Usually the offending moleculesare the monoclonal light chains (LCs), but the complete immunoglobulins can participate inthe pathogenesis of organ damage. The primary structure of the monoclonal proteins is at thebasis...
Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 150
Published: 12 May 2006
10.1159/000093505
EISBN: 978-3-318-01347-4
... membrane ina RAGE -/- mouse model. It could be demonstrated that RAGE plays a pivotal rolein structural damage (e.g. inflammation, neoangiogenesis and fibrosis) of the peritonealmembrane. Further investigations of this pathway with regard to preventing peritonealfibrosis should be performed to maintain...
Book Chapter
Series: Genome Dynamics
Volume: 1
Published: 27 March 2006
10.1159/000092500
EISBN: 978-3-318-01290-3
... Abstract Oxidative damage to DNA has been examined in many non-malignant conditions, inmost cases for its utility as a marker of oxidative stress. Whilst this may prove useful,attempts to answer the question - why might oxidative damage be important in this disease? -would provide added value...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 90
Published: 02 January 2006
10.1159/000088885
EISBN: 978-3-318-01251-4
Book Chapter