Search Results for damage

.... Challenges: It is of the utmost importance to recognize and adequately manage kidney injuries secondary to automobile events, since their timely identification can prevent permanent damage to the organ and, at times, save lives. Prevention and Treatment: An approach with a focus on traffic safety...

... Abstract Background: Hyperuricemia is a risk factor for causing end-stage kidney disease and cardiovascular disease in the general population; however, several aspects, such as the site of kidney damaged by hyperuricemia and the threshold levels of serum uric acid for the development...

... Abstract All living cells, including tissue-specific stem cells, are constantly exposed to DNA damage, such as altered DNA bases and DNA double-strand breaks. Experimental evidence suggests that DNA damage checkpoint genes not only influence stem cell function in response to DNA damage but also...

... Abstract Acute kidney injury (AKI) is a common but complex clinical syndrome with multiple etiologies. These etiologies target different sites and pathways within the kidney. Novel biomarkers of ‘kidney damage' (which can be tubular or glomerular) can be used to diagnose AKI, even...

... Abstract A multitude of sources induce lesions in cellular DNA. If left unrepaired, these DNA damages have the potential to trigger mutations and chromosomal aberrations that can initiate carcinogenesis. Cellular surveillance systems sense the presence of DNA damage and induce DNA damage...

... Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, decrease mucosal prostaglandin (PG) E 2 content by inhibiting cyclooxygenase (COX) activity and cause damage in the small intestine. The development of these lesions required the inhibition of both COX-1 and COX-2...

... Abstract In humans, nonsteroidal anti-inflammatory drugs (NSAIDs) cause mucosal damage in the small intestine as well as in the stomach and duodenum. Gastric and duodenal lesions caused by NSAIDs can be effectively treated with antisecretory agents; however, there are few effective agents...

... are urgently needed. In this review we will argue that (1) injury to the kidney is largely derived from local inflammation, (2) the triggers for this inflammation are derived from remote tissue damage, and (3) treatment directed at blocking damage signals or suppressing the response to them can attenuate...

... Abstract Several lines of evidence suggest that the accumulation of DNA damage contributes to organismal aging. Telomere dysfunction, replication errors and toxic metabolites (possibly including reactive oxygen species) represent some of the causes contributing to DNA damage accumulation during...

...-induced neuronal cell damage system. The treatment with DHA hydroperoxide (DHA-OOH) or 6-hydroxydopamine (6-OHDA), either of which is a reactive oxygen species (ROS)-inducing neurotoxin, led to a significant decrease in viable dopaminergic SH-SY5Y cells by the MTT assay, whereas a significant protection...

... patients show a microinflammatory state with an increasedpercentage of CD14+/CD16+ monocytes in peripheral blood, even in patients who do notshow clinical evidence of inflammatory disease. However, the role played by these microinflammatorycells on the endothelial damage that precede the development...

... Abstract The kidney is a target organ in plasma cell dyscrasias. Usually the offending moleculesare the monoclonal light chains (LCs), but the complete immunoglobulins can participate inthe pathogenesis of organ damage. The primary structure of the monoclonal proteins is at thebasis...

... membrane ina RAGE -/- mouse model. It could be demonstrated that RAGE plays a pivotal rolein structural damage (e.g. inflammation, neoangiogenesis and fibrosis) of the peritonealmembrane. Further investigations of this pathway with regard to preventing peritonealfibrosis should be performed to maintain...

... Abstract Oxidative damage to DNA has been examined in many non-malignant conditions, inmost cases for its utility as a marker of oxidative stress. Whilst this may prove useful,attempts to answer the question - why might oxidative damage be important in this disease? -would provide added value...