... for communication along the microbiome-gut-brain axis, including the vagus nerve, HPA axis, spinal cord, immune system, and peripheral transport of metabolites, among others. These have been reviewed in detail elsewhere (e.g., Cryan et al. [ 102 ]). Here, we will provide a brief and simplified overview of just two...

... and the Marine, Ireland, funded SMARTFOOD:Science Based “Intelligent”/Functional and Medical Foods for Optimum Brain Health, Targeting Depression and Cognition (2013–2017). References References 1. Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG: Minireview: Gut microbiota: the neglected...

..., Azmin S, Razlan H, Yahya NW, Tan HJ, Manaf MR, et al: Eradication of Helicobacter pylori infection improves levodopa action, clinical symptoms and quality of life in patients with Parkinson’s disease. PLoS One 2014;9:e112330. 109. Clarke G, Sandhu KV, Griffin BT, Dinan TG, Cryan JF, Hyland NP: Gut...

..., Cryan JF: Gut microbiota: the conductor in the orchestra of immune-neuroendocrine communication. Clin Ther 2015;37:954–967. 2. Grenham S, Clarke G, Cryan JF, Dinan TG: Brain-gut-microbe communication in health and disease. Front Physiol 2011;2:94. 3. Dinan TG, Stilling RM, Stanton C, Cryan JF...

...-28. 5. Cryan JF, Dinan TG: More than a gut feeling: the microbiota regulates neurodevelopment and behavior. Neuropsychopharmacology 2015;40:241-242. 6. Mayer EA, Knight R, Mazmanian SK, Cryan JF, Tillisch K: Gut microbes and the brain: paradigm shift in neuroscience. J Neurosci 2014;34:15490...

.... 24. Kessler RC, Bromet EJ: The epidemiology of depression across cultures. Annu Rev Public Health 2013;34:119-138. 25. Xiang X, An R: Depression and onset of cardiovascular disease in the US middle-aged and older adults. Aging Ment Health 2015, pp 1-9. 26. Dinan TG, Cryan JF: Melancholic...

...-enteric microbiota axis. Nat Rev Gastroenterol Hepatol 2009;6:306-314. 7. O'Mahony SM, Hyland NP, Dinan TG, Cryan JF: Maternal separation as a model of brain-gut axis dysfunction. Psychopharmacology 2011;214:71-88. 8. Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, Deng Y, Blennerhassett P...

...References References 1. El Aidy S, Dinan TG, Cryan JF: Gut microbiota: the conductor in the orchestra of immune-neuroendocrine communication. Clin Ther 2015;37:954–967. 2. Grenham S, Clarke G, Cryan JF, Dinan TG: Brain-gut-microbe communication in health and disease. Front Physiol 2011;2...

... . Animal models of depression: benefits and drawbacks (adopted from Cryan and Slattery [4]) Table 1. Animal models of depression: benefits and drawbacks (adopted from Cryan and Slattery [ 4 ]) AD Antidepressant The most widely utilised...

..., Christmas D, Swan J, Sorrell E: Animal models of depression: navigating through the clinical fog. Neurosci Biobehav Rev 2005;29:503-513 4. Cryan JF, Slattery DA: Animal models of mood disorders: recent developments. Curr Opin Psychiatry 2007;20:1-7 5. Frazer A, Morilak DA: What should animal models...

... Microbe 2008;3:417-427. 6. Rhee SH, Pothoulakis C, Mayer EA: Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol 2009;6:306-314. 7. O'Mahony SM, Hyland NP, Dinan TG, Cryan JF: Maternal separation as a model of brain-gut axis dysfunction...

...References References 1. O'Mahony SM, Hyland NP, Dinan TG, Cryan JF: Maternal separation as a model of brain-gut axis dysfunction. Psychopharmacology (Berl) 2011;214:71-88 2. Rhee SH, Pothoulakis C, Mayer EA: Principles and clinical implications of the brain-gut-enteric microbiota axis...

..., Rawls JF, Poulton S, et al: Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection. Brain Behav Immun 2016;51:14-28. 5. Cryan JF, Dinan TG: More than a gut feeling: the microbiota regulates neurodevelopment...

... adults. Aging Ment Health 2015, pp 1-9. 26. Dinan TG, Cryan JF: Melancholic microbes: a link between gut microbiota and depression? Neurogastroenterol Motil 2013;25:713-719. 27. Finn DP, Viveros MP, Marco EM: The endocannabinoid system and emotional processing: pathophysiology and therapeutic...

... diseases. Clin Psychopharmacol Neurosci 2016;14:131–147. 10. Dubos R: The microbiota of the gastrointestinal tract. Gastroenterology 1966;51:868–874. 11. Cryan JF, O’Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al: The microbiota-gut-brain axis. Physiol Rev 2019;99:1877–2013...

...References References 1. Dinan TG, Stanton C, Cryan JF: Psychobiotics: a novel class of psychotropic. Biol Psychiatry 2013;74:720–726. 2. Kali A: Psychobiotics: an emerging probiotic in psychiatric practice. Biomed J 2016:39:223–224. 3. Berdoy M, Webster JP, Macdonald DW: Fatal...

...References References 1. Mayer EA: Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci 2011;12:453-466. 2. Cryan JF, Dinan TG: Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012;13:701-712. 3. de Vos...

..., Creeden CL, Potenza MN, Feingold A, Jatlow PI: A placebo-controlled trial of bupropion combined with nicotine patch for smoking cessation in schizophrenia. Biol Psychiatry 2008;63:1092-1096 44. Rosenzweig-Lipson S, Sabb A, Stack G, Mitchell P, Lucki I, Malberg JE, Grauer S, Brennan J, Cryan JF, Sukoff...