... Abstract Coupled plasma filtration and adsorption (CPFA) is a detoxification system that combines a plasma adsorption circuit and a continuous renal replacement therapy circuit. Its main application is for sepsis and septic shock with or without acute renal failure. Several recent studies have...

... on these cell-free fluid phase (plasma). In this case, the treatment is plasma filtration adsorption dialysis (PFAD) or coupled plasma filtration adsorption (CPFA) [ 12‒14 ]. Plasma filtrate is produced in a separate unit (plasma filter) and then processed through a sorbent cartridge. After this process...

... use of extracorporeal blood purification techniques has increased. One of the emergingtreatments in patients with severe sepsis and septic shock is coupled plasma filtration adsorption(CPFA), a novel extracorporeal blood purification therapy aimed at a nonselective reductionof the circulating levels...

... for nonspecific adsorptive sorbents like CytoSorb and Jafron HA will be discussed along with the anticoagulation of specific adsorptive sorbents such as polymyxin-B hemoperfusion (PMX-B-HMP). Lastly, the anticoagulation of more specific techniques like coupled plasma filtration adsorption (CPFA) and double plasma...

...% in immunosuppressive patients. Downregulation of MHC II and CD14 expression on monocytes was also significantly improved by HVHF in the study by Yekebas et al. [ 8 ] discussed above. In a clinical study, coupled plasma filtration adsorption (CPFA) increased the HLA-DR expression in monocytes of septic patients [ 9...

... proposed. The latter are still under investigation, both for potential benefits and also for possible drawbacks (e.g., excessive leakage of albumin). In the following discussion, 3 relatively commonly used sorbent-based approaches are discussed. Continuous plasma filtration adsorption (CPFA...

... still not been established as to which mediators should be removed and which should not during different phases of sepsis [ 16 ] and finally, technology that is able to select molecules has not been developed so far. Coupled Plasma Filtration Adsorption Coupled plasma filtration adsorption (CPFA...

... adsorption (CPFA) is based on aspecific adsorption of inflammatory mediators onto a sorbent located after a plasma filter: CPFA can be integrated with a standard RRT circuit. Experimental studies showed that CPFA is able to prevent microvascular failure with a consequent improvement of hemodynamic...

... shock. Crit Care Med 2002;30:1250-1255. 6. Livigni S, Bertolini G, Rossi C, Ferrari F, Giardino M, Pozzato M, Remuzzi G: Efficacy of coupled plasma filtration adsorption (CPFA) in patients with septic shock: a multicenter randomised controlled clinical trial. BMJ Open 2014;4:e003536. 7. Amandola...

... the anion-exchange resin is used for plasmaperfusion. MediaSorb: hydrophobic styrene resin, average pore size is 30 nm. Therapy applied: coupled plasma filtration adsorption (CPFA) [ 11 ]. Endotype and Patient Selection for Artificial Liver Support Patients with acute liver failure or acute...

... and have been demonstrated to be quite efficient in removing poisons, bilirubin, cytokines or even endotoxin. Coupled Plasma Filtration-Adsorption Continuous plasma filtration-adsorption (CPFA) is a modality of blood purification in which plasma is separated from the whole blood by a plasma filter...

.... Intensive Care Med 2003;29:703-708. 19. Bellomo R, Tetta C, Ronco C: Coupled plasma filtration adsorption. Intensive Care Med 2003;29:1222-1228. 20. Livigni S, Bertolini G, Rossi C, et al: Efficacy of coupled plasma filtration adsorption (CPFA) in patients with septic shock: a multicenter randomised...

..., Venkataraman R, Powner D, Elder M, Hergenroeder G, Carter M: Feasibility study of cytokine removal by hemoadsorption in brain-dead humans. Crit Care Med 2008;36:268-272. 66. Livigni S, Bertolini G, Rossi C, Ferrari F, Giardino M, Pozzato M, et al: Efficacy of coupled plasma filtration adsorption (CPFA...