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convection

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Book Chapter
Series: Progress in Neurological Surgery
Volume: 32
Published: 23 July 2018
10.1159/000469687
EISBN: 978-3-318-06063-8
... Abstract Convection-enhanced delivery (CED) is a novel method of bypassing the blood-brain barrier for administration of therapeutic agents directly into brain with a potential to provide concentrations that cannot be achieved with systemic drug delivery. This technique has grown significantly...
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Book Chapter
Series: Contributions to Nephrology
Volume: 149
Published: 10 May 2005
10.1159/000085469
EISBN: 978-3-318-01222-4
... Abstract Although hemodiafiltration (HDF) offers the advantage of increased convective clearancefor middle molecules, there is still controversy as to whether reinfusion should occurpre- or postfilter. Mid-dilution hemodiafiltration (MD HDF) is a new HDF technique thatuses a special dialyzer...
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Book Chapter
Series: Contributions to Nephrology
Volume: 189
Published: 22 December 2016
10.1159/000450634
EISBN: 978-3-318-05929-8
... Abstract Conventional diffusion-based dialysis modalities including high-flux hemodialysis are limited in their capacity to effectively remove large uremic toxins and to improve outcomes for end-stage chronic kidney disease (ESKD) patients. By increasing convective solute transport...
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Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527707
EISBN: 978-3-318-07124-5
...) and is removed from its solvent (i.e., blood or plasma). Traditional extracorporeal blood purification techniques utilize semipermeable membranes and depend mainly on diffusion and convection as mechanisms of mass transfer. Protein-bound solutes and water-soluble compounds with molecular weight above 25 kDa...
Book Chapter
Series: Contributions to Nephrology
Volume: 189
Published: 22 December 2016
10.1159/000450632
EISBN: 978-3-318-05929-8
... to demonstrate a positive effect of OL-HDF on patient survival in comparison to those randomized to HD. Post hoc analyses of these studies consistently showed that the patients randomized to OL-HDF who received the highest convection volumes had a lower risk of mortality and cardiovascular events than those...
Book Chapter
Series: Contributions to Nephrology
Volume: 191
Published: 18 September 2017
10.1159/000479261
EISBN: 978-3-318-06117-8
... weight solute removal and albumin loss. Another defining feature of this membrane class is the relatively small fiber diameter, which produces high convective volumes in the form of internal filtration. The aim of the present study was to estimate, by semi-empirical methods, convective volumes for 2 new...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527953
EISBN: 978-3-318-07124-5
... dialysis membranes and techniques. Improvements have been made in enhancing both membrane permeability and convection rates as in the case for expanded hemodialysis (HD) and hemodiafiltration, but these techniques still present limitations or cannot be performed due to technical reasons. Considering...
Book Chapter
Series: Contributions to Nephrology
Volume: 189
Published: 22 December 2016
10.1159/000450637
EISBN: 978-3-318-05929-8
... Abstract There is considerable evidence to suggest that on-line hemodiafiltration (HDF) is superior to standard hemodialysis when comparing effects on clinical end points, especially when a certain minimum convection volume can be achieved. In this chapter we address the question of whether...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 32
Published: 23 July 2018
EISBN: 978-3-318-06063-8
... 2007;25:2295-2305. 6. Levin VA: A pharmacologic basis for brain tumor chemotherapy. Semin Oncol 1975;2:57-61. 7. Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH: Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U S A 1994;91:2076-2080. 8...