... for the evaluation of outcomes and for the critical appraisal of findings. Summary: In stroke research, outcomes are mainly represented by composite end points focusing on the occurrence of cardiovascular and cerebrovascular events in trials on primary and secondary prevention and by measures of recovery...

... Abstract Vascularized composite allotransplantation (VCA) is the youngest field in organ transplantation. While not necessarily life-saving per se, VCA was introduced with the intention to treat complex and otherwise untreatable tissue injuries and defects of complex body elements...

... Abstract Vascularized composite allotransplantation (VCA) can achieve close to optimal aesthetic restoration of devastating tissue defects not amenable to conventional reconstruction, with improved functional outcomes and avoidance of multiple surgeries or donor site morbidity. During the past...

... Abstract Vascularized composite allotransplantation (VCA) has demonstrated promising results and potential, expanding possibilities for defects not amenable to reconstruction by means of autologous tissue transplantation. Success in VCA relies on multidisciplinary efforts derived from different...

... Abstract Vascularized composite allotransplantation (VCA) poses different challenges to solid organ transplantation because of the immunogenicity difference of different tissues in a single composite allograft, as well as the difficulties in functional assessment of the allograft. The majority...

... Abstract Although vascularized composite allotransplantation (VCA) of the face and extremities has been successfully performed with satisfactory aesthetic and functional outcomes, potentially serious side effects derived from long-term immunosuppression impede broader application of VCA...

... detailed in vivo observation into all major domains of vascularized composite allotransplantation research, including rejection and tolerance, structural and functional recoveries, and therapeutic assessments. In the laboratory setting, tissomic studies allow validation of the observed event from...

.... Their characteristics prompted their evaluation as candidate molecular markers and therapeutic agents to monitor or treat patients with vascularized composite allotransplantation (VCA): their specific circulating expression profile that could serve as noninvasive predictive tools or surrogate end points for rejection...

... they can be generated from the patient's own somatic cells through various reprogramming techniques, iPSCs have great potential in disease modeling, drug screening, regenerative medicine, and cell therapy. Vascularized composite allotransplantation (VCA) differs from organ transplantation involving...

... Abstract The most appropriate dialysate composition is one of the central topics in dialysistreatment. The prescription of a certain dialysate composition could change in order to obtainnot only an adequate blood purification but also a high tolerability. Sodium balance representsthe...

... of vascularized composite allotransplantation. Autologous free tissue transfer has changed the face of reconstructive surgery. What was once deemed unsalvageable or nonreconstructable can now be restored to a high level of form and function with a touch of magic. However, and in spite of the refinements...

... Abstract Vascularized composite allotransplantation (VCA) has emerged as a viable means of restoring forms and functions in patients with significant tissue defects. However, administration of lifelong immunosuppression in VCA is complicated with side effects and reduces immunocompetence...